Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relBE/ParE-RelB
Location 527173..527689 Replicon chromosome
Accession NZ_CP014755
Organism Klebsiella pneumoniae strain AATZP

Toxin (Protein)


Gene name relE Uniprot ID A0A2A2BGN7
Locus tag WM86_RS02635 Protein ID WP_009486548.1
Coordinates 527405..527689 (+) Length 95 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID R4Y888
Locus tag WM86_RS02630 Protein ID WP_002886901.1
Coordinates 527173..527415 (+) Length 81 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
WM86_RS02615 523201..523941 + 741 WP_009486551.1 KDGP aldolase family protein -
WM86_RS02620 524008..525162 + 1155 WP_002886900.1 lactonase family protein -
WM86_RS02625 525185..527095 + 1911 WP_009486549.1 BglG family transcription antiterminator -
WM86_RS02630 527173..527415 + 243 WP_002886901.1 type II toxin-antitoxin system RelB/DinJ family antitoxin Antitoxin
WM86_RS02635 527405..527689 + 285 WP_009486548.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
WM86_RS02640 527693..528157 - 465 WP_002886903.1 anaerobic ribonucleoside-triphosphate reductase-activating protein -
WM86_RS02645 528465..530603 - 2139 WP_004186701.1 anaerobic ribonucleoside-triphosphate reductase -
WM86_RS02655 530960..531703 - 744 WP_002886905.1 MurR/RpiR family transcriptional regulator -
WM86_RS29550 531706..531879 - 174 WP_032433782.1 hypothetical protein -
WM86_RS02665 531964..532272 + 309 WP_012737232.1 PTS sugar transporter subunit IIB -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(5-83)

Antitoxin

RelB antitoxin/Antitoxin DinJ

(1-80)


Sequences

Toxin        


Download         Length: 95 a.a.        Molecular weight: 11125.95 Da        Isoelectric Point: 10.4951

>T61745 WP_009486548.1 NZ_CP014755:527405-527689 [Klebsiella pneumoniae]
MTYELEFDPRARREWQKPGETVKKQFKNKLQQIVQNPRIESTRLSDLPDCYKIKLKASGYRLVYQVRDSVVVVYVIAIGK
REKAAVYHQANKRL

Download         Length: 285 bp

>T61745 NZ_CP014755:527405-527689 [Klebsiella pneumoniae]
ATGACCTATGAACTGGAGTTTGATCCACGAGCCAGGCGCGAATGGCAGAAGCCTGGCGAGACGGTCAAAAAACAGTTCAA
AAATAAGCTCCAGCAGATTGTGCAGAATCCGCGAATTGAGTCGACCAGGCTGAGCGATTTACCGGATTGCTACAAAATCA
AGCTTAAGGCGTCAGGTTATCGGTTGGTGTATCAAGTACGAGATAGTGTGGTGGTGGTTTACGTTATTGCCATTGGCAAA
AGAGAGAAAGCGGCCGTTTATCATCAGGCGAATAAACGGCTCTAA

Antitoxin


Download         Length: 81 a.a.        Molecular weight: 9045.55 Da        Isoelectric Point: 6.3340

>AT61745 WP_002886901.1 NZ_CP014755:527173-527415 [Klebsiella pneumoniae]
MATLNVRLDDKLKKEAYAVLEKLDMTPTEAVRLLFQYIAENGRMPVKSMTISDGEAALLRTVRERLENPRPGVKVSLDDL

Download         Length: 243 bp

>AT61745 NZ_CP014755:527173-527415 [Klebsiella pneumoniae]
ATGGCCACGCTCAATGTTCGACTGGACGATAAACTCAAAAAAGAGGCTTATGCCGTGCTGGAGAAACTCGATATGACACC
AACGGAGGCGGTACGCCTGCTGTTTCAATACATTGCGGAAAATGGCCGCATGCCGGTGAAAAGTATGACCATCAGTGATG
GCGAAGCGGCGTTATTACGCACCGTTCGCGAACGGCTGGAAAACCCACGGCCAGGGGTTAAGGTGAGTCTGGATGACCTA
TGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A2A2BGN7

Antitoxin

Source ID Structure
AlphaFold DB A0A0H3GLP0

References