Detailed information of TA system TA061740

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): relBE/Phd(antitoxin)
• Location: 2420979..2421526
• Replicon: chromosome
• Accession: NZ_CP014754
• Organism: Marinobacter sp. LQ44

Toxin (Protein)

• Gene name: relE
• Uniprot ID: A0A142FRV4
• Locus tag: ASQ50_RS11185
• Protein ID: WP_058090860.1
• Coordinates: 2421224..2421526 (+)
• Length: 101 a.a.

Antitoxin (Protein)

• Gene name: relB
• Uniprot ID: U7FV42
• Locus tag: ASQ50_RS11180
• Protein ID: WP_022990189.1
• Coordinates: 2420979..2421236 (+)
• Length: 86 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
ASQ50_RS11140	2416772..2417113	+	342	WP_058090867.1	ribonuclease E inhibitor RraB	-
ASQ50_RS11145	2417243..2417557	+	315	WP_058090866.1	hypothetical protein	-
ASQ50_RS11150	2417550..2417849	+	300	WP_058090865.1	helix-turn-helix domain-containing protein	-
ASQ50_RS11155	2418314..2419357	-	1044	WP_058090864.1	IS110 family transposase	-
ASQ50_RS11160	2419512..2419913	-	402	WP_054641852.1	PIN domain nuclease	-
ASQ50_RS11165	2419910..2420104	-	195	WP_058090863.1	type II toxin-antitoxin system VapB family antitoxin	-
ASQ50_RS11170	2420279..2420557	+	279	WP_058090862.1	type II toxin-antitoxin system RelE/ParE family toxin	-
ASQ50_RS11175	2420557..2420850	+	294	WP_058090861.1	HigA family addiction module antidote protein	-
ASQ50_RS11180	2420979..2421236	+	258	WP_022990189.1	type II toxin-antitoxin system Phd/YefM family antitoxin	Antitoxin
ASQ50_RS11185	2421224..2421526	+	303	WP_058090860.1	type II toxin-antitoxin system RelE/ParE family toxin	Toxin
ASQ50_RS20815	2422310..2423554	+	1245	Protein_2218	EAL domain-containing protein	-
ASQ50_RS11195	2423532..2424602	-	1071	WP_058090858.1	magnesium/cobalt transporter CorA	-
ASQ50_RS11200	2424788..2425294	+	507	WP_058090857.1	hypothetical protein	-
ASQ50_RS11205	2425360..2426316	+	957	WP_197492682.1	DUF560 domain-containing protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Genomic island	-	-	2409664..2421746	12082
	-	flank	IS/Tn	-	-	2418314..2419357	1043

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin-antitoxin system, RelE/ParE toxin family (4-91)

Antitoxin

• Type II toxin-antitoxin system, antitoxin Phd/YefM (1-72)

Sequences

Toxin

Protein

• Length: 101 a.a.
• Molecular weight: 11607.34 Da
• Isoelectric Point: 4.4766

>T61740 WP_058090860.1 NZ_CP014754:2421224-2421526 [Marinobacter sp. LQ44]
MAEVIWTEPALQELDAVAEYIALDNPAAASHLIKEVFDKTERLEDFPQSGRIPPELPNSVYREVVVPPCRIFYREDEKRV
LILYVMREERQLRAFMLGSS

Nucleotide

• Length: 303 bp

>T61740 NZ_CP014754:2421224-2421526 [Marinobacter sp. LQ44]
ATGGCTGAAGTAATCTGGACGGAGCCTGCCCTTCAAGAACTGGATGCCGTCGCTGAGTACATCGCTCTGGATAATCCTGC
TGCCGCAAGTCATCTGATTAAAGAAGTTTTCGATAAGACCGAGCGATTGGAAGATTTTCCCCAATCCGGACGGATTCCTC
CCGAACTCCCCAATTCGGTATACAGAGAGGTAGTGGTTCCACCGTGTCGTATTTTTTATCGTGAGGATGAGAAGCGGGTT
CTCATCCTCTATGTCATGCGAGAGGAGCGGCAGCTTCGTGCGTTCATGCTTGGAAGCAGCTAA

Antitoxin

Protein

• Length: 86 a.a.
• Molecular weight: 9887.41 Da
• Isoelectric Point: 8.5042

>AT61740 WP_022990189.1 NZ_CP014754:2420979-2421236 [Marinobacter sp. LQ44]
MKVELVTNLKRQATKILADLHLSKEPVLITEHGQPSAYLVDVQDYEFMQRRLELLEGLSRGERAVLEGRTYSQSEAREKM
SKWLK

Nucleotide

• Length: 258 bp

>AT61740 NZ_CP014754:2420979-2421236 [Marinobacter sp. LQ44]
ATGAAAGTCGAGCTTGTTACGAACCTCAAGCGCCAAGCCACAAAAATTCTGGCCGATCTGCACCTGTCTAAAGAACCGGT
ACTGATCACGGAGCATGGCCAGCCATCCGCATACCTTGTCGATGTGCAGGATTACGAGTTTATGCAGCGCCGGCTTGAGC
TGCTTGAGGGGCTCTCACGAGGAGAGCGTGCTGTACTTGAGGGAAGAACGTACAGCCAAAGTGAGGCTAGGGAGAAAATG
AGTAAATGGCTGAAGTAA

Structures

Toxin

• AlphaFold DB: A0A142FRV4

Antitoxin

• AlphaFold DB: A0A1I1I6C4