Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) Hha-TomB/-
Location 3269837..3270456 Replicon chromosome
Accession NZ_CP014748
Organism Klebsiella aerogenes strain FDAARGOS_139

Toxin (Protein)


Gene name Hha Uniprot ID A0A0H3FXE2
Locus tag AL497_RS16500 Protein ID WP_015367918.1
Coordinates 3269837..3270055 (-) Length 73 a.a.

Antitoxin (Protein)


Gene name TomB Uniprot ID A0A0H3FPM3
Locus tag AL497_RS16505 Protein ID WP_015367917.1
Coordinates 3270082..3270456 (-) Length 125 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
AL497_RS16470 3265910..3266170 + 261 WP_015367923.1 type B 50S ribosomal protein L31 -
AL497_RS16475 3266173..3266313 + 141 WP_003859006.1 type B 50S ribosomal protein L36 -
AL497_RS16480 3266310..3267020 - 711 WP_015367922.1 GNAT family N-acetyltransferase -
AL497_RS16485 3267123..3268577 + 1455 WP_015367921.1 PLP-dependent aminotransferase family protein -
AL497_RS16490 3268552..3269016 - 465 WP_015367920.1 YlaC family protein -
AL497_RS16495 3269142..3269705 - 564 WP_015367919.1 maltose O-acetyltransferase -
AL497_RS16500 3269837..3270055 - 219 WP_015367918.1 hemolysin expression modulator Hha Toxin
AL497_RS16505 3270082..3270456 - 375 WP_015367917.1 Hha toxicity modulator TomB Antitoxin
AL497_RS16510 3270929..3274075 - 3147 WP_015367916.1 multidrug efflux RND transporter permease subunit -
AL497_RS16515 3274098..3275297 - 1200 WP_020079451.1 multidrug efflux RND transporter periplasmic adaptor subunit AcrA -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Haemolysin expression modulating, HHA

(13-69)

Antitoxin

Biofilm formation regulator YbaJ

(1-116)


Sequences

Toxin        


Download         Length: 73 a.a.        Molecular weight: 8569.96 Da        Isoelectric Point: 9.4828

>T61731 WP_015367918.1 NZ_CP014748:c3270055-3269837 [Klebsiella aerogenes]
MSGKPLTKTDYLMRLRRCQTIDTLERVIEKNKYELSDNELAVFYSAADHRLAELTMNKLYDKIPTSVWKFIR

Download         Length: 219 bp

>T61731 NZ_CP014748:c3270055-3269837 [Klebsiella aerogenes]
ATGTCTGGTAAACCATTAACTAAAACAGACTATTTGATGCGTTTACGCCGCTGTCAGACAATTGATACGCTGGAGCGCGT
AATTGAAAAGAATAAATATGAACTTTCCGACAATGAATTGGCGGTATTTTACTCAGCAGCCGACCATCGTCTTGCTGAAT
TGACCATGAATAAGCTATACGACAAAATCCCAACTTCAGTATGGAAATTTATCCGCTAG

Antitoxin


Download         Length: 125 a.a.        Molecular weight: 14464.21 Da        Isoelectric Point: 4.9045

>AT61731 WP_015367917.1 NZ_CP014748:c3270456-3270082 [Klebsiella aerogenes]
MDEYSPKRHDIAQLRFLCETLYHDCLANLEESNRGWVNDPTSAVNLQLNELIEHIATYALNYKIKYAEDNKLISQLDEYL
DDTFMLFSSYGINTSDLQKWRKSGNRLFRCFVNASRENPASLSC

Download         Length: 375 bp

>AT61731 NZ_CP014748:c3270456-3270082 [Klebsiella aerogenes]
ATGGACGAGTACTCGCCAAAAAGACATGATATCGCGCAGCTAAGATTTCTCTGCGAAACGTTGTATCATGACTGCCTTGC
AAACCTGGAAGAAAGCAACCGCGGCTGGGTTAACGATCCCACCTCGGCGGTGAATCTTCAATTAAATGAATTGATCGAGC
ACATAGCAACTTACGCGCTTAATTATAAAATTAAGTACGCTGAGGATAATAAGCTGATTTCTCAGCTTGATGAATACCTG
GATGACACTTTTATGCTGTTCAGTAGCTATGGCATAAACACAAGCGATCTCCAAAAATGGCGCAAATCCGGCAATCGGTT
ATTCCGATGCTTTGTGAACGCCAGCCGGGAGAACCCGGCAAGTCTTTCTTGTTAG

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0H3FXE2

Antitoxin

Source ID Structure
AlphaFold DB A0A0H3FPM3

References