Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type IV Classification (family/domain) ypjF-yeeU/CbtA-CbeA
Location 866701..867481 Replicon chromosome
Accession NZ_CP014748
Organism Klebsiella aerogenes strain FDAARGOS_139

Toxin (Protein)


Gene name ypjF Uniprot ID -
Locus tag AL497_RS04525 Protein ID WP_015370123.1
Coordinates 867152..867481 (+) Length 110 a.a.

Antitoxin (Protein)


Gene name yeeU Uniprot ID -
Locus tag AL497_RS04520 Protein ID WP_127175768.1
Coordinates 866701..867099 (+) Length 133 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
AL497_RS04470 862161..862568 + 408 WP_032710459.1 hypothetical protein -
AL497_RS04475 862641..862868 + 228 WP_049045116.1 hypothetical protein -
AL497_RS04480 862868..863113 + 246 WP_032710460.1 hypothetical protein -
AL497_RS04485 863171..864007 + 837 WP_015370130.1 hypothetical protein -
AL497_RS04490 864101..864334 + 234 WP_015370129.1 DUF905 domain-containing protein -
AL497_RS04495 864432..865250 + 819 WP_015370128.1 DUF945 domain-containing protein -
AL497_RS04505 865520..865999 + 480 WP_049045115.1 antirestriction protein -
AL497_RS04510 866011..866490 + 480 WP_049045114.1 DNA repair protein RadC -
AL497_RS04515 866511..866732 + 222 WP_015370125.1 DUF987 domain-containing protein -
AL497_RS04520 866701..867099 + 399 WP_127175768.1 type IV toxin-antitoxin system YeeU family antitoxin Antitoxin
AL497_RS04525 867152..867481 + 330 WP_015370123.1 TA system toxin CbtA family protein Toxin
AL497_RS04530 867889..867990 + 102 Protein_766 preprotein translocase -
AL497_RS04535 868149..868949 - 801 WP_061856912.1 nucleotidyltransferase domain-containing protein -
AL497_RS04540 869125..869661 - 537 WP_015370121.1 dihydrofolate reductase family protein -
AL497_RS04545 869861..870223 - 363 WP_015370120.1 cupin domain-containing protein -
AL497_RS04550 870299..871117 - 819 WP_032706441.1 AraC family transcriptional regulator -
AL497_RS04555 871445..871672 - 228 WP_071647620.1 DUF1272 domain-containing protein -
AL497_RS26340 871963..872115 + 153 WP_157844032.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

CbtA toxin of type IV toxin-antitoxin system

(1-107)

Antitoxin

Antitoxin CbeA

(33-131)


Sequences

Toxin        


Download         Length: 110 a.a.        Molecular weight: 12493.28 Da        Isoelectric Point: 7.3984

>T61728 WP_015370123.1 NZ_CP014748:867152-867481 [Klebsiella aerogenes]
MQTLSLHPTRATQPYLSPVETWQRLLTHLLSEHYGLTLNDTPFSYETTIREHIDAGVSLSDAVNFLVEKYGLVRIDRKGF
SWQEQTPYISVVDILMARRSTGLLKTTVK

Download         Length: 330 bp

>T61728 NZ_CP014748:867152-867481 [Klebsiella aerogenes]
ATGCAAACCTTATCATTACACCCGACAAGGGCGACTCAGCCCTATCTGTCACCCGTTGAAACCTGGCAACGGCTGCTGAC
TCATCTTTTATCGGAGCACTATGGCCTGACGCTGAATGACACACCGTTCAGTTATGAAACCACCATACGGGAACATATTG
ATGCAGGAGTATCGCTCAGCGATGCGGTGAACTTTCTGGTAGAAAAATACGGGCTTGTCCGTATCGACCGGAAAGGATTT
TCATGGCAAGAACAGACCCCGTATATTTCCGTAGTAGATATTCTGATGGCAAGGCGCTCGACCGGCCTGCTAAAAACTAC
CGTGAAATAA

Antitoxin


Download         Length: 133 a.a.        Molecular weight: 14730.76 Da        Isoelectric Point: 7.0372

>AT61728 WP_127175768.1 NZ_CP014748:866701-867099 [Klebsiella aerogenes]
MSSCAASRSINVNLRKAKLSNEIPAVNHDIAEPWWGLKTTVTPYFGARLVQEGNRLHYLADRASITGTFSDADLRHLDQA
FPVLLKQLELMLVSGELTSRHQHRITLYHNGLTCEADTLGSCGYVYIAIYPD

Download         Length: 399 bp

>AT61728 NZ_CP014748:866701-867099 [Klebsiella aerogenes]
ATGTCGTCCTGCGCAGCGTCACGCTCAATTAACGTTAATTTAAGGAAAGCTAAATTGTCGAATGAAATACCGGCAGTAAA
CCACGATATTGCCGAACCCTGGTGGGGACTCAAAACCACCGTCACGCCGTACTTTGGCGCACGACTGGTGCAGGAAGGCA
ACCGGCTGCATTACCTGGCTGATCGTGCCAGTATCACCGGGACATTCAGCGACGCGGATTTACGCCATCTCGACCAGGCG
TTTCCGGTATTGCTTAAACAGCTGGAGTTGATGCTCGTTTCCGGTGAGCTCACCTCCCGCCATCAGCACCGCATCACGCT
ATATCACAATGGACTGACTTGCGAAGCCGATACACTCGGCTCTTGTGGTTACGTCTACATCGCTATTTATCCCGACTAG

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References