Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) hipBA/HipA-HipB
Location 1421435..1423052 Replicon plasmid unnamed
Accession NZ_CP014703
Organism Ralstonia solanacearum strain KACC 10722

Toxin (Protein)


Gene name hipA Uniprot ID -
Locus tag LBM2029_RS21775 Protein ID WP_075467845.1
Coordinates 1421706..1423052 (+) Length 449 a.a.

Antitoxin (Protein)


Gene name hipB Uniprot ID -
Locus tag LBM2029_RS21770 Protein ID WP_013210321.1
Coordinates 1421435..1421701 (+) Length 89 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
LBM2029_RS21740 1416687..1417163 + 477 WP_075467835.1 RidA family protein -
LBM2029_RS21745 1417266..1418105 + 840 WP_075467838.1 AraC family transcriptional regulator -
LBM2029_RS21750 1418108..1419226 + 1119 WP_075467841.1 peptidase -
LBM2029_RS21755 1419253..1419636 - 384 WP_075468668.1 VOC family protein -
LBM2029_RS21760 1419876..1420319 + 444 WP_172840169.1 PGDYG domain-containing protein -
LBM2029_RS21765 1420335..1421240 - 906 WP_075467842.1 hypothetical protein -
LBM2029_RS21770 1421435..1421701 + 267 WP_013210321.1 helix-turn-helix domain-containing protein Antitoxin
LBM2029_RS21775 1421706..1423052 + 1347 WP_075467845.1 type II toxin-antitoxin system HipA family toxin Toxin
LBM2029_RS21780 1423129..1424025 + 897 WP_075467848.1 DUF2236 domain-containing protein -
LBM2029_RS21785 1424029..1425597 - 1569 WP_075467852.1 MFS transporter -
LBM2029_RS21790 1425690..1426640 - 951 WP_075467854.1 LysR family transcriptional regulator -
LBM2029_RS21795 1426780..1427406 + 627 WP_075467857.1 FMN-dependent NADH-azoreductase -
LBM2029_RS25410 1427540..1427686 - 147 WP_162897835.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Non-Mobilizable plasmid - cheY / cyaB / flgC / flgG / fliM / fliG / fliI / acrB / adeG / cheY / cheB / cheW / motA 1..1883432 1883432


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

HipA, N-terminal subdomain 1

(11-111)

Antitoxin

Cro/C1-type helix-turn-helix domain

(17-67)


Sequences

Toxin        


Download         Length: 449 a.a.        Molecular weight: 49734.05 Da        Isoelectric Point: 7.8445

>T61718 WP_075467845.1 NZ_CP014703:1421706-1423052 [Ralstonia solanacearum]
MGRRSHTRALGLWMNGTHVGHWELHPHQGDVLKYAASWVAAPEGRPLSLSLPFTPDNAPYKGPAVRAYFENLLPDSRDIR
ERIARRFQAGTTEAFDLLEQIGRDCIGALQVLPADMAPAGIGDIDAEPLTEAQIAQTLRETVAPTPLGGMPEDDGNFRIS
IAGAQEKTAFLQIDGRWYRPRGATPTSHIFKLPMGRVGNMKLDLSESVENEWLCSLVLRAYGLPIAHCRPLVFEDQKVLA
VERFDRMWRDHRGRQLIRLPQEDMCQATATPPHLKYEADGGPGIDRIMGLLDGSARRDADRLMLFQSQVLFWMLCAPDGH
AKNFSLALRPGGAYALTPLYDVMSAYPLLGEGPGKLSPHRIRLAMAVRSKNPHWKMQDVQRRHWLGLGQRHGIVTPEGGH
AAAIVDSLAARTPEVIRTVRALLPEDFPQPLADRILRGLQSAADRLAE

Download         Length: 1347 bp

>T61718 NZ_CP014703:1421706-1423052 [Ralstonia solanacearum]
ATGGGGCGCCGGTCGCATACGCGGGCCCTCGGGCTCTGGATGAATGGCACCCATGTCGGCCACTGGGAGCTGCACCCGCA
TCAAGGCGATGTGCTGAAGTACGCGGCGTCCTGGGTGGCCGCGCCCGAGGGGCGGCCCTTGTCGCTATCCCTGCCCTTCA
CGCCGGACAACGCGCCGTACAAAGGCCCGGCGGTCCGGGCATATTTCGAAAACCTCCTGCCGGACAGCCGCGACATCCGC
GAGCGCATTGCGCGCCGGTTCCAGGCGGGCACGACCGAGGCATTCGACCTGCTGGAGCAGATCGGCCGCGACTGCATCGG
CGCCCTGCAGGTGCTGCCCGCCGACATGGCCCCGGCCGGCATCGGCGACATCGACGCGGAGCCGCTGACCGAGGCGCAGA
TCGCGCAGACGCTGCGGGAGACGGTCGCCCCGACGCCCCTGGGCGGCATGCCGGAGGACGACGGCAATTTCCGCATCTCG
ATTGCCGGCGCGCAGGAAAAGACCGCCTTCCTCCAGATCGACGGACGCTGGTACCGCCCCCGGGGCGCGACGCCGACCAG
CCACATCTTCAAGCTGCCGATGGGGCGGGTCGGCAACATGAAGCTGGACCTGAGCGAGTCGGTGGAAAACGAATGGCTGT
GCTCCCTGGTGCTGCGGGCGTATGGGCTGCCCATCGCCCACTGCCGGCCGCTGGTGTTCGAAGACCAGAAAGTCCTGGCC
GTGGAACGGTTCGACCGCATGTGGCGGGACCACCGCGGCAGGCAGCTCATCCGCCTGCCGCAGGAAGACATGTGCCAGGC
GACGGCCACGCCCCCGCACCTGAAGTACGAGGCCGACGGCGGCCCCGGCATCGACCGCATCATGGGCCTGCTCGACGGCT
CCGCGCGCCGGGATGCCGACCGCCTGATGCTGTTCCAGAGCCAGGTGCTGTTCTGGATGCTGTGCGCGCCCGACGGCCAT
GCGAAGAACTTCAGCCTCGCGCTTCGCCCCGGCGGCGCCTACGCGCTCACGCCGCTGTACGACGTGATGTCGGCCTACCC
GCTGCTGGGCGAGGGGCCGGGCAAGCTCTCGCCGCACCGGATCCGGCTGGCAATGGCCGTCCGCTCGAAGAACCCGCACT
GGAAAATGCAAGACGTCCAGCGGCGCCACTGGCTGGGCCTGGGCCAGCGGCATGGCATCGTCACGCCCGAGGGCGGGCAT
GCGGCCGCCATCGTGGACAGTCTGGCCGCCCGGACCCCCGAGGTGATCCGCACCGTGCGCGCGCTGCTGCCGGAAGACTT
CCCGCAGCCGCTGGCCGACCGCATTCTGCGAGGGCTGCAGAGCGCCGCGGACAGGCTCGCGGAATAG

Antitoxin


Download         Length: 89 a.a.        Molecular weight: 9743.27 Da        Isoelectric Point: 11.3495

>AT61718 WP_013210321.1 NZ_CP014703:1421435-1421701 [Ralstonia solanacearum]
MNEFIVRTPEQLPAILKGFRKQAGLSQAELAARMGMRQQTLSALERNAENVSAGRLMRLLSVLGVELVLRKPDASGERGR
PASDQPQW

Download         Length: 267 bp

>AT61718 NZ_CP014703:1421435-1421701 [Ralstonia solanacearum]
ATGAACGAGTTCATCGTACGCACCCCCGAGCAGTTGCCGGCGATTCTCAAGGGCTTCCGCAAACAGGCCGGGCTGAGCCA
GGCTGAACTGGCCGCCCGGATGGGCATGCGCCAGCAAACCCTCTCCGCGCTGGAGCGCAACGCAGAAAACGTGAGCGCCG
GACGGCTGATGCGCCTGTTGTCGGTGCTGGGCGTCGAGCTGGTGCTGCGCAAACCCGACGCCTCCGGCGAGCGCGGCCGC
CCGGCATCCGACCAGCCGCAGTGGTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References