Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type IV Classification (family/domain) cptAB/Cpta(toxin)
Location 2978361..2979018 Replicon chromosome
Accession NZ_CP014696
Organism Klebsiella quasipneumoniae strain ATCC 700603 isolate K6

Toxin (Protein)


Gene name cptA Uniprot ID A0A2A5MNX1
Locus tag AVR78_RS15265 Protein ID WP_004205323.1
Coordinates 2978361..2978771 (-) Length 137 a.a.

Antitoxin (Protein)


Gene name cptB Uniprot ID W8UQ37
Locus tag AVR78_RS15270 Protein ID WP_002916312.1
Coordinates 2978752..2979018 (-) Length 89 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
AVR78_RS15245 2974361..2976094 - 1734 WP_004205327.1 single-stranded-DNA-specific exonuclease RecJ -
AVR78_RS15250 2976100..2976813 - 714 WP_004205326.1 bifunctional protein-disulfide isomerase/oxidoreductase DsbC -
AVR78_RS15255 2976836..2977732 - 897 WP_004144729.1 site-specific tyrosine recombinase XerD -
AVR78_RS15260 2977833..2978354 + 522 WP_004205324.1 flavodoxin FldB -
AVR78_RS15265 2978361..2978771 - 411 WP_004205323.1 protein YgfX Toxin
AVR78_RS15270 2978752..2979018 - 267 WP_002916312.1 FAD assembly factor SdhE Antitoxin
AVR78_RS15275 2979264..2980247 + 984 WP_004205321.1 tRNA-modifying protein YgfZ -
AVR78_RS15280 2980404..2981063 - 660 WP_004205319.1 hemolysin III family protein -
AVR78_RS15285 2981226..2981537 - 312 WP_004205318.1 N(4)-acetylcytidine aminohydrolase -
AVR78_RS15290 2981587..2982315 + 729 WP_004205316.1 MurR/RpiR family transcriptional regulator -
AVR78_RS15295 2982434..2983867 + 1434 WP_004205314.1 6-phospho-beta-glucosidase BglA -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Inner membrane protein YgfX

(3-132)

Antitoxin

Flavinator of succinate dehydrogenase

(7-79)


Sequences

Toxin        


Download         Length: 137 a.a.        Molecular weight: 16035.83 Da        Isoelectric Point: 11.4778

>T61706 WP_004205323.1 NZ_CP014696:c2978771-2978361 [Klebsiella quasipneumoniae]
VVLWQSDLRISWRAQWFSLLLHGVVAALVLLVPWPLSYTPIWLLLLSLVVFDCVRSQRRIHARRGEIKLLTDSRLRWQNA
DWEILGTPWVINSGMLLRLRHVDTRRGQHLWLAADSMDAGEWRDLRRLVLQKPAQE

Download         Length: 411 bp

>T61706 NZ_CP014696:c2978771-2978361 [Klebsiella quasipneumoniae]
GTGGTCCTGTGGCAATCTGATCTCCGTATCTCCTGGCGCGCGCAGTGGTTTTCTCTGCTGCTCCACGGCGTTGTGGCGGC
GCTGGTGCTGCTGGTTCCCTGGCCGTTAAGCTACACCCCGATCTGGCTGCTGCTGCTGTCGCTGGTGGTCTTTGACTGTG
TGCGCAGCCAGCGACGGATCCATGCCCGTCGCGGGGAGATAAAACTGCTCACCGATTCCCGGCTGCGCTGGCAAAACGCC
GACTGGGAGATCCTCGGGACGCCGTGGGTCATCAACAGCGGAATGCTGCTGCGTTTGCGCCATGTCGATACCCGACGCGG
TCAGCATCTGTGGCTGGCGGCGGACAGCATGGATGCCGGAGAGTGGCGGGACCTGCGCCGGCTGGTGCTGCAAAAACCGG
CGCAGGAGTAA

Antitoxin


Download         Length: 89 a.a.        Molecular weight: 10480.98 Da        Isoelectric Point: 5.1116

>AT61706 WP_002916312.1 NZ_CP014696:c2979018-2978752 [Klebsiella quasipneumoniae]
MDINNKARIHWACRRGMRELDISIMPFFEYEYDTLSDADKQLFIRLLENDDPDLFNWLMNHGKPADAELQRMVTLIQTRN
RERGPVAI

Download         Length: 267 bp

>AT61706 NZ_CP014696:c2979018-2978752 [Klebsiella quasipneumoniae]
ATGGACATTAACAATAAAGCTCGTATCCACTGGGCATGCCGCCGCGGGATGCGCGAACTCGACATCTCCATCATGCCGTT
CTTTGAGTATGAGTACGATACCCTCAGCGACGCTGACAAACAGCTGTTCATTCGCCTGCTGGAAAATGACGATCCGGATC
TATTCAACTGGCTGATGAACCATGGCAAACCGGCCGATGCGGAGCTGCAGCGGATGGTAACCTTAATTCAGACACGGAAT
CGGGAACGTGGTCCTGTGGCAATCTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A2A5MNX1

Antitoxin

Source ID Structure
AlphaFold DB A0A0H3GY41

References