Detailed information of TA system TA061695

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): hicAB/-
• Location: 3591758..3592341
• Replicon: chromosome
• Accession: NZ_CP014692
• Organism: Acetobacter aceti strain TMW2.1153

Toxin (Protein)

• Gene name: hicA
• Uniprot ID: -
• Locus tag: A0U92_RS16490
• Protein ID: WP_077814061.1
• Coordinates: 3592087..3592341 (-)
• Length: 85 a.a.

Antitoxin (Protein)

• Gene name: hicB
• Uniprot ID: -
• Locus tag: A0U92_RS16485
• Protein ID: WP_077814060.1
• Coordinates: 3591758..3592090 (-)
• Length: 111 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
A0U92_RS16465	3587842..3590025	+	2184	WP_077814057.1	M1 family metallopeptidase	-
A0U92_RS17925	3590393..3590575	-	183	Protein_3222	hypothetical protein	-
A0U92_RS16475	3591156..3591452	-	297	WP_077814059.1	YggT family protein	-
A0U92_RS16485	3591758..3592090	-	333	WP_077814060.1	type II toxin-antitoxin system HicB family antitoxin	Antitoxin
A0U92_RS16490	3592087..3592341	-	255	WP_077814061.1	type II toxin-antitoxin system HicA family toxin	Toxin
A0U92_RS16495	3592582..3592920	+	339	WP_077814062.1	hypothetical protein	-
A0U92_RS16505	3593942..3594352	+	411	WP_077814064.1	pentapeptide repeat-containing protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• HicA mRNA interferase family (23-77)

Antitoxin

• Uncharacterised protein family HicB (55-105)

Sequences

Toxin

Protein

• Length: 85 a.a.
• Molecular weight: 9429.78 Da
• Isoelectric Point: 10.0864

>T61695 WP_077814061.1 NZ_CP014692:c3592341-3592087 [Acetobacter aceti]
MKAKDRRTLELVFKRPVSGNVPWTDIEALFIALGGEVSEREGSRVGVFLFRESRAFHRPHPKPDTDKGAVAAVSKWLEQN
EVAP

Nucleotide

• Length: 255 bp

>T61695 NZ_CP014692:c3592341-3592087 [Acetobacter aceti]
ATGAAAGCCAAAGATCGCCGCACGCTGGAGCTTGTCTTCAAGCGTCCCGTCTCCGGCAATGTGCCATGGACTGACATCGA
AGCCCTGTTCATTGCTCTTGGTGGGGAAGTGTCAGAACGGGAAGGCTCCCGCGTTGGCGTGTTCCTGTTTAGAGAGAGCC
GGGCGTTCCATCGTCCGCACCCCAAACCGGACACTGACAAGGGAGCTGTTGCAGCGGTAAGCAAATGGCTTGAGCAGAAT
GAGGTGGCGCCATGA

Antitoxin

Protein

• Length: 111 a.a.
• Molecular weight: 12101.81 Da
• Isoelectric Point: 6.0804

>AT61695 WP_077814060.1 NZ_CP014692:c3592090-3591758 [Acetobacter aceti]
MNNMMEISGHRAVIQFDPEIGLFRGEFVGLNGGADFYADSVEGLRQEGKTSLRVFLEMCTEKGIEPVKHYSGKFQVRLPP
EAHARAVEMAAARGVSLNRLVQDALEHVAG

Nucleotide

• Length: 333 bp

>AT61695 NZ_CP014692:c3592090-3591758 [Acetobacter aceti]
ATGAACAACATGATGGAGATAAGCGGCCATCGGGCCGTCATTCAGTTTGATCCTGAAATCGGCCTGTTTCGGGGCGAGTT
CGTTGGCCTGAATGGCGGGGCTGACTTTTATGCCGACAGCGTGGAAGGTCTCCGGCAGGAAGGAAAAACGTCTCTGCGTG
TCTTTCTGGAGATGTGTACGGAAAAAGGTATCGAGCCTGTGAAGCACTATTCCGGCAAGTTTCAGGTGCGTCTGCCGCCT
GAAGCGCATGCTCGGGCCGTCGAGATGGCAGCCGCCCGCGGCGTCAGCCTGAATCGGCTTGTTCAGGATGCGCTGGAGCA
CGTGGCAGGCTGA