Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/VapC-VagC
Location 121223..121851 Replicon plasmid pGS1191_1
Accession NZ_CP014690
Organism Gluconobacter albidus strain TMW2.1191

Toxin (Protein)


Gene name vapC Uniprot ID -
Locus tag A0U94_RS14955 Protein ID WP_077804116.1
Coordinates 121223..121627 (-) Length 135 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID -
Locus tag A0U94_RS14960 Protein ID WP_077804235.1
Coordinates 121627..121851 (-) Length 75 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
A0U94_RS14935 116731..117948 + 1218 WP_077804113.1 hypothetical protein -
A0U94_RS14940 117945..119480 + 1536 WP_077804114.1 SUMF1/EgtB/PvdO family nonheme iron enzyme -
A0U94_RS14945 119562..120254 + 693 WP_149026837.1 hypothetical protein -
A0U94_RS15790 120284..120769 + 486 WP_149026838.1 hypothetical protein -
A0U94_RS14950 120779..120988 - 210 Protein_129 IS481 family transposase -
A0U94_RS15795 121057..121187 + 131 Protein_130 transposase -
A0U94_RS14955 121223..121627 - 405 WP_077804116.1 tRNA(fMet)-specific endonuclease VapC Toxin
A0U94_RS14960 121627..121851 - 225 WP_077804235.1 AbrB/MazE/SpoVT family DNA-binding domain-containing protein Antitoxin
A0U94_RS14965 122046..122507 - 462 WP_077804117.1 hypothetical protein -
A0U94_RS14970 122633..123169 + 537 WP_077804118.1 SMC-Scp complex subunit ScpB -
A0U94_RS14975 123321..124319 + 999 WP_077804119.1 site-specific integrase -
A0U94_RS14980 124323..125108 + 786 WP_077804120.1 hypothetical protein -
A0U94_RS14985 125101..125880 + 780 WP_077804121.1 segregation/condensation protein A -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Non-Mobilizable plasmid - - 1..261375 261375


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(4-123)

Antitoxin

SpoVT-AbrB domain

(9-44)


Sequences

Toxin        


Download         Length: 135 a.a.        Molecular weight: 15190.31 Da        Isoelectric Point: 6.2355

>T61693 WP_077804116.1 NZ_CP014690:c121627-121223 [Gluconobacter albidus]
MLRYLLDTNFCIRVLRDRPKGLRERFNDNAEALCISDIVLYELLYGAEKSQNPAKIRREVEHFSGRLSVLPFDDDAAAHT
AEIRADLEARGCVIGPYDLMIAGHARSKGLVVITGNLREFTRVNGLRSEDWTPD

Download         Length: 405 bp

>T61693 NZ_CP014690:c121627-121223 [Gluconobacter albidus]
ATGCTACGTTATCTTCTGGATACAAATTTTTGTATCCGCGTCTTGCGTGACCGTCCAAAGGGCTTACGCGAACGTTTCAA
CGATAACGCCGAGGCCCTCTGTATTTCAGATATTGTGCTTTACGAACTCCTTTATGGGGCGGAAAAATCTCAAAATCCGG
CAAAAATCCGACGTGAGGTAGAGCATTTTTCTGGACGTTTGTCTGTTTTGCCATTTGACGATGATGCGGCAGCACATACA
GCAGAAATCAGGGCTGATCTGGAAGCCCGTGGGTGTGTTATCGGACCGTACGACTTAATGATTGCGGGGCACGCCCGGAG
CAAAGGACTGGTCGTTATAACCGGAAATCTACGAGAATTTACCCGGGTAAATGGATTACGTTCTGAAGATTGGACGCCGG
ATTAA

Antitoxin


Download         Length: 75 a.a.        Molecular weight: 8300.51 Da        Isoelectric Point: 7.0109

>AT61693 WP_077804235.1 NZ_CP014690:c121851-121627 [Gluconobacter albidus]
MLARTTLFLSNRSQAVRLPKAVAFDLSLKEVVIIPDGVRRIIAPAHAAWDDFFSSSGTELPERNQPAMQERESF

Download         Length: 225 bp

>AT61693 NZ_CP014690:c121851-121627 [Gluconobacter albidus]
ATGCTTGCCCGCACAACTCTCTTTCTTTCCAATCGTTCTCAGGCTGTACGGCTTCCCAAAGCTGTTGCCTTTGACCTTAG
TCTGAAGGAGGTCGTGATCATTCCCGATGGCGTACGACGCATTATTGCGCCCGCGCATGCCGCATGGGATGATTTTTTTT
CGTCCTCCGGCACTGAGTTACCCGAACGCAATCAACCTGCAATGCAGGAACGCGAAAGCTTTTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References