Detailed information of TA system TA061691

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): relBE/RHH(antitoxin)
• Location: 17601..18163
• Replicon: plasmid pKB16680_1
• Accession: NZ_CP014682
• Organism: Kozakia baliensis strain NBRC 16680

Toxin (Protein)

• Gene name: relE
• Uniprot ID: A0A1D8UXM1
• Locus tag: A0U90_RS13210
• Protein ID: WP_070403865.1
• Coordinates: 17601..17882 (-)
• Length: 94 a.a.

Antitoxin (Protein)

• Gene name: relB
• Uniprot ID: -
• Locus tag: A0U90_RS13215
• Protein ID: WP_070406047.1
• Coordinates: 17879..18163 (-)
• Length: 95 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
A0U90_RS13170	12638..13396	-	759	WP_070406041.1	hypothetical protein	-
A0U90_RS13180	13825..14430	+	606	WP_051625851.1	hypothetical protein	-
A0U90_RS13185	14427..15254	+	828	WP_070406043.1	hypothetical protein	-
A0U90_RS13190	15251..15718	+	468	WP_070406044.1	hypothetical protein	-
A0U90_RS13195	15877..16620	+	744	WP_151199948.1	hypothetical protein	-
A0U90_RS13200	16648..17049	+	402	WP_151199949.1	hypothetical protein	-
A0U90_RS13205	17216..17419	-	204	WP_070404055.1	hypothetical protein	-
A0U90_RS13210	17601..17882	-	282	WP_070403865.1	type II toxin-antitoxin system RelE/ParE family toxin	Toxin
A0U90_RS13215	17879..18163	-	285	WP_070406047.1	ribbon-helix-helix protein, CopG family	Antitoxin
A0U90_RS13220	18245..18445	-	201	WP_070406048.1	hypothetical protein	-
A0U90_RS13225	18495..18980	-	486	WP_083301972.1	hypothetical protein	-
A0U90_RS13230	18977..19417	-	441	WP_070404050.1	hypothetical protein	-
A0U90_RS13235	19483..19974	-	492	WP_070406049.1	single-stranded DNA-binding protein	-
A0U90_RS13240	20221..20430	-	210	WP_151199932.1	hypothetical protein	-
A0U90_RS15510	20939..21079	-	141	WP_158513431.1	hypothetical protein	-
A0U90_RS13245	21066..21374	-	309	WP_070406051.1	hypothetical protein	-
A0U90_RS13250	21447..22127	-	681	WP_029605140.1	hypothetical protein	-
A0U90_RS13255	22450..22713	-	264	WP_070406052.1	hypothetical protein	-
A0U90_RS13260	22705..22908	+	204	WP_070406053.1	hypothetical protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Non-Mobilizable plasmid	-	-	1..135727	135727

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin-antitoxin system, RelE/ParE toxin family (3-88)

Antitoxin

• Ribbon-helix-helix protein, CopG (11-48)

Sequences

Toxin

Protein

• Length: 94 a.a.
• Molecular weight: 10868.42 Da
• Isoelectric Point: 5.6327

>T61691 WP_070403865.1 NZ_CP014682:c17882-17601 [Kozakia baliensis]
VKLQWSAKALSDLHDLTREFESPRTAARIIQRLVAVPDVLAEFPRMGVALADFAPREVRRFIVDDYEIRYELTDAVLIVT
DIFHTRQDRETFH

Nucleotide

• Length: 282 bp

>T61691 NZ_CP014682:c17882-17601 [Kozakia baliensis]
GTGAAGCTCCAATGGTCCGCCAAGGCCCTGTCCGACCTGCACGACCTGACCAGAGAATTCGAGAGCCCGCGAACCGCCGC
CCGGATCATTCAGCGTCTCGTCGCCGTTCCCGACGTGCTGGCGGAGTTTCCCCGCATGGGAGTCGCGCTGGCGGATTTCG
CCCCGCGCGAGGTGCGTCGCTTTATCGTGGACGATTACGAGATTCGTTACGAATTGACCGACGCGGTCCTGATCGTCACC
GACATATTCCATACGCGGCAGGATCGGGAGACTTTTCATTGA

Antitoxin

Protein

• Length: 95 a.a.
• Molecular weight: 10419.77 Da
• Isoelectric Point: 5.1532

>AT61691 WP_070406047.1 NZ_CP014682:c18163-17879 [Kozakia baliensis]
MSEKQLSKQTVSVQMPAELVEAMDRYGEAIERPRSWVMREAVSAYLAREDEKNRATRRALADIDAGRVVGHDAVRQWAAS
LDSDTPLPLPVPGA

Nucleotide

• Length: 285 bp

>AT61691 NZ_CP014682:c18163-17879 [Kozakia baliensis]
ATGAGTGAGAAACAGCTATCCAAGCAGACCGTCAGCGTGCAGATGCCCGCCGAACTGGTCGAGGCCATGGACCGCTATGG
TGAGGCGATCGAGCGGCCCCGCTCATGGGTCATGCGCGAAGCCGTAAGCGCCTATCTCGCCCGTGAGGATGAGAAGAACC
GCGCCACCCGCCGTGCGCTGGCCGACATCGACGCGGGCCGTGTCGTGGGTCATGACGCGGTTCGTCAATGGGCCGCCAGT
CTCGACAGCGATACCCCGCTACCTCTGCCGGTGCCCGGGGCGTGA

Structures

Toxin

• AlphaFold DB: A0A1D8UXM1