Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/VapC-VagC
Location 719..1347 Replicon plasmid pKB16680_1
Accession NZ_CP014682
Organism Kozakia baliensis strain NBRC 16680

Toxin (Protein)


Gene name vapC Uniprot ID -
Locus tag A0U90_RS13120 Protein ID WP_003630720.1
Coordinates 943..1347 (+) Length 135 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID C7JJ36
Locus tag A0U90_RS13115 Protein ID WP_012813340.1
Coordinates 719..943 (+) Length 75 a.a.

Genomic Context

A0U90_RS13115A0U90_RS13120A0U90_RS14990A0U90_RS13125A0U90_RS13130A0U90_RS13135
Location: 719..943 (225 bp)
Type: Antitoxin
Protein ID: WP_012813340.1
Location: 943..1347 (405 bp)
Type: Toxin
Protein ID: WP_003630720.1
Location: 1555..1755 (201 bp)
Type: Others
Protein ID: WP_012813343.1
Location: 1756..2061 (306 bp)
Type: Others
Protein ID: WP_012813344.1
Location: 2337..3332 (996 bp)
Type: Others
Protein ID: WP_070406036.1
Location: 3406..4671 (1266 bp)
Type: Others
Protein ID: WP_070406037.1
ToxinAntitoxinOther genes
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Locus tag
Coordinates
Strand
Size (bp)
Protein ID
Product
Description
A0U90_RS13115719..943+225WP_012813340.1AbrB/MazE/SpoVT family DNA-binding domain-containing proteinAntitoxin
A0U90_RS13120943..1347+405WP_003630720.1tRNA(fMet)-specific endonuclease VapCToxin
A0U90_RS149901555..1755+201WP_012813343.1type II toxin-antitoxin system CcdA family antitoxin-
A0U90_RS131251756..2061+306WP_012813344.1CcdB family protein-
A0U90_RS131302337..3332+996WP_070406036.1restriction endonuclease-
A0U90_RS131353406..4671+1266WP_070406037.1SIR2 family protein-

Associated MGEs

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MGE
detail
Similar
MGEs
Relative
position
MGE Type
Cargo ARG
Virulence gene
Coordinates
Length (bp)
-insideNon-Mobilizable plasmid--1..135727135727


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(4-123)

Antitoxin

SpoVT-AbrB domain

(9-46)


Sequences

Toxin        


Download         Length: 135 a.a.        Molecular weight: 15152.26 Da        Isoelectric Point: 6.0964

>T61690 WP_003630720.1 NZ_CP014682:943-1347 [Kozakia baliensis]
MLRYLLDTNFCIRVLRDRPQGLRERFNDNAEALCISDVVLYELLYGAEKSHDPAKIRREVEHFAARLSVLPFDDDAAAHT
AEIRAELEKRGCVIGPYDLMIAGHARSRGLVVVTGNLRELTRVDGLRSEDWTAG

Download         Length: 405 bp

>T61690 NZ_CP014682:943-1347 [Kozakia baliensis]
ATGCTTCGTTATCTTCTGGATACAAACTTTTGCATTCGTGTCCTGCGTGATCGTCCGCAAGGCTTGCGTGAGCGTTTCAA
TGATAACGCCGAGGCGCTCTGCATCTCGGATGTCGTGCTTTACGAACTTCTCTATGGAGCCGAAAAATCTCACGATCCGG
CAAAGATTCGACGTGAGGTTGAGCATTTTGCCGCACGTCTGTCTGTTTTGCCGTTTGATGATGACGCCGCAGCCCATACA
GCGGAAATCAGGGCAGAGCTGGAAAAGCGTGGCTGTGTCATCGGCCCATACGATTTGATGATTGCCGGGCACGCTCGAAG
CAGGGGGCTTGTCGTTGTGACTGGAAACTTACGAGAACTTACGAGGGTAGATGGGTTGCGATCTGAGGATTGGACGGCCG
GTTAA

Antitoxin


Download         Length: 75 a.a.        Molecular weight: 8310.55 Da        Isoelectric Point: 8.9793

>AT61690 WP_012813340.1 NZ_CP014682:719-943 [Kozakia baliensis]
MLTRTTLFLSNRSQAVRLPKAVAFDVNLKDVVIIPDGARRIIAPANAAWDDFFAAPGTPLPERDQPRMQERESF

Download         Length: 225 bp

>AT61690 NZ_CP014682:719-943 [Kozakia baliensis]
ATGCTCACCCGCACGACGCTCTTTCTGTCCAATCGCTCCCAGGCCGTGCGTCTTCCCAAAGCGGTTGCATTTGACGTCAA
CCTGAAAGACGTCGTGATCATCCCGGACGGTGCGCGTCGTATAATCGCACCTGCAAATGCCGCATGGGACGATTTCTTTG
CCGCGCCGGGCACTCCACTGCCTGAGCGTGATCAGCCGAGGATGCAGGAACGCGAAAGCTTCTGA

Similar Proteins

Only experimentally validated proteins are listed.

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Protein
Organism
Identities (%)
Coverage (%)
Ha-value
No matching records found
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Protein
Organism
Identities (%)
Coverage (%)
Ha-value
No matching records found

Structures

Toxin

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Source
ID
Structure
No matching records found

Antitoxin

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Source
ID
Structure
AlphaFold DBA0A511FS67

References