Detailed information of TA system
Bioinformatically predictedOverview
TA module
Type | II | Classification (family/domain) | vapBC/VapC-StbC |
Location | 4689..5359 | Replicon | plasmid pKB14400_5 |
Accession | NZ_CP014679 | ||
Organism | Kozakia baliensis strain DSM 14400 |
Toxin (Protein)
Gene name | vapC | Uniprot ID | A0A318PNR1 |
Locus tag | A0U89_RS16485 | Protein ID | WP_034931108.1 |
Coordinates | 4937..5359 (+) | Length | 141 a.a. |
Antitoxin (Protein)
Gene name | vapB | Uniprot ID | A0A1D8UZ46 |
Locus tag | A0U89_RS16480 | Protein ID | WP_010512463.1 |
Coordinates | 4689..4940 (+) | Length | 84 a.a. |
Genomic Context
Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
---|---|---|---|---|---|---|
A0U89_RS16460 | 47..406 | - | 360 | WP_070404321.1 | conjugal transfer protein TraD | - |
A0U89_RS16465 | 503..3874 | + | 3372 | WP_083278626.1 | Ti-type conjugative transfer relaxase TraA | - |
A0U89_RS16470 | 3921..4343 | + | 423 | WP_007396294.1 | putative toxin-antitoxin system toxin component, PIN family | - |
A0U89_RS16475 | 4340..4603 | + | 264 | WP_070404322.1 | toxin-antitoxin system HicB family antitoxin | - |
A0U89_RS16480 | 4689..4940 | + | 252 | WP_010512463.1 | plasmid stabilization protein | Antitoxin |
A0U89_RS16485 | 4937..5359 | + | 423 | WP_034931108.1 | type II toxin-antitoxin system VapC family toxin | Toxin |
A0U89_RS16490 | 5424..5618 | + | 195 | WP_070404323.1 | type II toxin-antitoxin system VapB family antitoxin | - |
A0U89_RS16495 | 5615..6007 | + | 393 | WP_070404324.1 | PIN domain nuclease | - |
A0U89_RS16505 | 6301..6972 | + | 672 | WP_070404342.1 | hypothetical protein | - |
A0U89_RS16510 | 7146..7931 | - | 786 | WP_070404326.1 | IS21-like element helper ATPase IstB | - |
A0U89_RS16515 | 7921..9445 | - | 1525 | Protein_10 | IS21 family transposase | - |
Associated MGEs
MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
---|---|---|---|---|---|---|---|
- | inside | Non-Mobilizable plasmid | - | - | 1..35463 | 35463 |
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 141 a.a. Molecular weight: 15266.54 Da Isoelectric Point: 5.2375
>T61687 WP_034931108.1 NZ_CP014679:4937-5359 [Kozakia baliensis]
MILLDTNVISEPWKPVPEPRVLAWIDGQAIETLFLSAVTVAELRFGIGAMPSGRRRSVLHERLEQEVLPLFAGRVLSFDL
AASQAYAELMVRARSEGRAIGKADGYIAATAASRGYVVASRDVSPFEAAGVRVLNPWEET
MILLDTNVISEPWKPVPEPRVLAWIDGQAIETLFLSAVTVAELRFGIGAMPSGRRRSVLHERLEQEVLPLFAGRVLSFDL
AASQAYAELMVRARSEGRAIGKADGYIAATAASRGYVVASRDVSPFEAAGVRVLNPWEET
Download Length: 423 bp
>T61687 NZ_CP014679:4937-5359 [Kozakia baliensis]
ATGATCCTGCTCGATACCAATGTGATCTCGGAGCCGTGGAAGCCCGTCCCGGAGCCGCGTGTTCTGGCCTGGATCGATGG
ACAGGCGATCGAGACGCTTTTCCTGTCGGCCGTCACGGTGGCGGAGCTGCGTTTCGGGATCGGGGCGATGCCGTCTGGTC
GGCGGCGTTCTGTACTGCATGAGCGGCTGGAACAGGAGGTATTGCCCCTGTTCGCGGGGCGTGTCCTGTCGTTCGATCTG
GCGGCGTCTCAGGCCTATGCCGAACTGATGGTGCGGGCCAGATCAGAGGGCCGCGCAATTGGCAAGGCAGATGGCTATAT
TGCAGCAACCGCTGCATCCCGAGGTTATGTCGTGGCCAGCCGCGACGTGTCTCCTTTCGAGGCGGCCGGTGTGCGGGTTC
TCAATCCGTGGGAGGAGACCTGA
ATGATCCTGCTCGATACCAATGTGATCTCGGAGCCGTGGAAGCCCGTCCCGGAGCCGCGTGTTCTGGCCTGGATCGATGG
ACAGGCGATCGAGACGCTTTTCCTGTCGGCCGTCACGGTGGCGGAGCTGCGTTTCGGGATCGGGGCGATGCCGTCTGGTC
GGCGGCGTTCTGTACTGCATGAGCGGCTGGAACAGGAGGTATTGCCCCTGTTCGCGGGGCGTGTCCTGTCGTTCGATCTG
GCGGCGTCTCAGGCCTATGCCGAACTGATGGTGCGGGCCAGATCAGAGGGCCGCGCAATTGGCAAGGCAGATGGCTATAT
TGCAGCAACCGCTGCATCCCGAGGTTATGTCGTGGCCAGCCGCGACGTGTCTCCTTTCGAGGCGGCCGGTGTGCGGGTTC
TCAATCCGTGGGAGGAGACCTGA
Antitoxin
Download Length: 84 a.a. Molecular weight: 9093.39 Da Isoelectric Point: 6.4584
>AT61687 WP_010512463.1 NZ_CP014679:4689-4940 [Kozakia baliensis]
MSSVVIRNLPEETHRALKAQAMLHGRSTEAEIRTILEAAVRPPQRVRLGSLLASIGREAGVCDQDIAALQTRDQTPAEPM
SFE
MSSVVIRNLPEETHRALKAQAMLHGRSTEAEIRTILEAAVRPPQRVRLGSLLASIGREAGVCDQDIAALQTRDQTPAEPM
SFE
Download Length: 252 bp
>AT61687 NZ_CP014679:4689-4940 [Kozakia baliensis]
ATGTCCTCTGTGGTTATTCGCAATCTTCCGGAAGAGACGCATCGGGCGCTGAAGGCGCAGGCCATGCTGCATGGGCGCAG
TACGGAAGCAGAGATCCGGACCATTCTGGAAGCGGCCGTCCGGCCGCCGCAGCGGGTCCGGCTGGGATCGCTTCTGGCGT
CCATCGGGCGGGAGGCCGGTGTGTGTGATCAGGATATTGCGGCCTTGCAGACCCGCGATCAGACCCCGGCCGAGCCGATG
TCCTTCGAATGA
ATGTCCTCTGTGGTTATTCGCAATCTTCCGGAAGAGACGCATCGGGCGCTGAAGGCGCAGGCCATGCTGCATGGGCGCAG
TACGGAAGCAGAGATCCGGACCATTCTGGAAGCGGCCGTCCGGCCGCCGCAGCGGGTCCGGCTGGGATCGCTTCTGGCGT
CCATCGGGCGGGAGGCCGGTGTGTGTGATCAGGATATTGCGGCCTTGCAGACCCGCGATCAGACCCCGGCCGAGCCGATG
TCCTTCGAATGA
Similar Proteins
Only experimentally validated proteins are listed.
Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
---|
Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
---|
Structures
Toxin
Source | ID | Structure |
---|---|---|
AlphaFold DB | A0A318PNR1 |
Antitoxin
Source | ID | Structure |
---|---|---|
AlphaFold DB | A0A1D8UZ46 |