Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) PumAB/upstrm_HI1419-dnstrm_HI1420
Location 97299..97891 Replicon plasmid pKB14400_2
Accession NZ_CP014676
Organism Kozakia baliensis strain DSM 14400

Toxin (Protein)


Gene name PumA Uniprot ID A0A1D8UYG6
Locus tag A0U89_RS15525 Protein ID WP_070404161.1
Coordinates 97589..97891 (-) Length 101 a.a.

Antitoxin (Protein)


Gene name PumB Uniprot ID A0A511GYX8
Locus tag A0U89_RS15520 Protein ID WP_070404160.1
Coordinates 97299..97592 (-) Length 98 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
A0U89_RS15490 93383..93982 + 600 WP_147061410.1 hypothetical protein -
A0U89_RS15495 94144..94809 + 666 WP_147061409.1 FAD-binding oxidoreductase -
A0U89_RS15500 94806..95273 + 468 WP_070404157.1 hypothetical protein -
A0U89_RS15505 95431..96183 + 753 WP_148662540.1 hypothetical protein -
A0U89_RS17670 96195..96587 + 393 WP_148662538.1 hypothetical protein -
A0U89_RS15510 96626..96832 - 207 WP_070404171.1 hypothetical protein -
A0U89_RS15515 96964..97284 - 321 WP_070404159.1 hypothetical protein -
A0U89_RS15520 97299..97592 - 294 WP_070404160.1 putative addiction module antidote protein Antitoxin
A0U89_RS15525 97589..97891 - 303 WP_070404161.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
A0U89_RS15530 97979..98179 - 201 WP_070404162.1 hypothetical protein -
A0U89_RS15535 98229..98735 - 507 WP_083278601.1 hypothetical protein -
A0U89_RS15540 98801..99292 - 492 WP_070404163.1 single-stranded DNA-binding protein -
A0U89_RS17675 99661..99885 + 225 WP_169829257.1 hypothetical protein -
A0U89_RS17935 99933..100121 - 189 WP_029605134.1 hypothetical protein -
A0U89_RS17940 100466..100606 - 141 WP_158513599.1 hypothetical protein -
A0U89_RS17680 100593..100901 - 309 WP_148662539.1 hypothetical protein -
A0U89_RS15560 100974..101654 - 681 WP_029605140.1 hypothetical protein -
A0U89_RS17685 101977..102156 - 180 WP_147061400.1 hypothetical protein -
A0U89_RS15565 102233..102436 + 204 WP_070404045.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Non-Mobilizable plasmid - - 1..102455 102455


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Addiction module killer protein, predicted

(1-96)

Antitoxin

Uncharacterized protein HI1420

(12-94)


Sequences

Toxin        


Download         Length: 101 a.a.        Molecular weight: 11464.31 Da        Isoelectric Point: 10.7436

>T61686 WP_070404161.1 NZ_CP014676:c97891-97589 [Kozakia baliensis]
MMQVQQTRQFREWLASLRDQRATAKIRARLILMEAGAFGDVEPCGEGISETRLHYGPGYRIYFVQRGNVLVIVLGGGTKR
TQPKDIRRAKELARDVEKFL

Download         Length: 303 bp

>T61686 NZ_CP014676:c97891-97589 [Kozakia baliensis]
ATGATGCAGGTTCAGCAGACACGCCAGTTTCGCGAATGGCTTGCCAGCCTACGAGATCAGAGAGCAACGGCCAAAATCCG
TGCCCGTCTGATCCTAATGGAGGCCGGGGCGTTCGGGGATGTCGAACCGTGCGGAGAAGGTATTTCCGAAACCCGTCTGC
ATTACGGGCCAGGTTATCGCATTTACTTTGTGCAGCGCGGAAACGTGCTTGTCATTGTGCTTGGCGGCGGCACGAAAAGA
ACGCAGCCGAAAGACATCAGGCGGGCGAAGGAATTGGCCCGCGACGTGGAGAAATTCCTATGA

Antitoxin


Download         Length: 98 a.a.        Molecular weight: 9940.27 Da        Isoelectric Point: 4.6062

>AT61686 WP_070404160.1 NZ_CP014676:c97592-97299 [Kozakia baliensis]
MSDQAELEVFDSVSAAADPAVQVELLNMAWADGDSAGIAHALAVIAKARGMSTTAADAGLTRPALYKALSERGNPSLSSL
LGIMNALGVKAHFQISN

Download         Length: 294 bp

>AT61686 NZ_CP014676:c97592-97299 [Kozakia baliensis]
ATGAGCGACCAAGCAGAACTTGAGGTGTTCGATTCCGTCTCGGCGGCCGCCGATCCTGCGGTGCAGGTTGAATTGCTGAA
TATGGCATGGGCGGATGGTGACAGCGCCGGAATTGCCCACGCTCTTGCCGTCATAGCGAAGGCCCGCGGTATGAGCACGA
CAGCGGCAGACGCTGGCCTGACTCGCCCAGCGCTTTATAAGGCGTTGTCGGAGCGGGGAAACCCGAGCCTCTCCAGCTTG
CTGGGCATTATGAACGCTCTCGGCGTGAAAGCGCATTTTCAGATTTCAAATTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A1D8UYG6

Antitoxin

Source ID Structure
AlphaFold DB A0A511GYX8

References