Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relBE/ParE-RelB
Location 83036..83586 Replicon plasmid pKB14400_2
Accession NZ_CP014676
Organism Kozakia baliensis strain DSM 14400

Toxin (Protein)


Gene name relE Uniprot ID C7JII7
Locus tag A0U89_RS15440 Protein ID WP_003618711.1
Coordinates 83293..83586 (+) Length 98 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID D5QDQ9
Locus tag A0U89_RS15435 Protein ID WP_003618686.1
Coordinates 83036..83296 (+) Length 87 a.a.

Genomic Context

A0U89_RS15400A0U89_RS15405A0U89_RS15410A0U89_RS17930A0U89_RS17205A0U89_RS15435A0U89_RS15440A0U89_RS15445A0U89_RS15450A0U89_RS15455A0U89_RS15430A0U89_RS15460
Location: 78321..78959 (639 bp)
Type: Others
Protein ID: WP_070404147.1
Location: 78968..79306 (339 bp)
Type: Others
Protein ID: WP_181015904.1
Location: 79303..79686 (384 bp)
Type: Others
Protein ID: WP_048854875.1
Location: 80264..80428 (165 bp)
Type: Others
Protein ID: WP_158513598.1
Location: 82645..82755 (111 bp)
Type: Others
Protein ID: Protein_92
Location: 83036..83296 (261 bp)
Type: Antitoxin
Protein ID: WP_003618686.1
Location: 83293..83586 (294 bp)
Type: Toxin
Protein ID: WP_003618711.1
Location: 83718..84980 (1263 bp)
Type: Others
Protein ID: WP_070404149.1
Location: 84980..85663 (684 bp)
Type: Others
Protein ID: WP_029604387.1
Location: 86102..86812 (711 bp)
Type: Others
Protein ID: WP_147061376.1
Location: 81738..82568 (831 bp)
Type: Others
Protein ID: WP_070404170.1
Location: 87017..87790 (774 bp)
Type: Others
Protein ID: WP_070404151.1
ToxinAntitoxinOther genes
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Locus tag
Coordinates
Strand
Size (bp)
Protein ID
Product
Description
A0U89_RS1540078321..78959+639WP_070404147.1tyrosine-type recombinase/integrase-
A0U89_RS1540578968..79306+339WP_181015904.1prevent-host-death protein-
A0U89_RS1541079303..79686+384WP_048854875.1type II toxin-antitoxin system VapC family toxin-
A0U89_RS1793080264..80428+165WP_158513598.1hypothetical protein-
A0U89_RS1543081738..82568-831WP_070404170.1IS5 family transposase-
A0U89_RS1720582645..82755+111Protein_92zinc-binding dehydrogenase-
A0U89_RS1543583036..83296+261WP_003618686.1type II toxin-antitoxin system RelB/DinJ family antitoxinAntitoxin
A0U89_RS1544083293..83586+294WP_003618711.1type II toxin-antitoxin system mRNA interferase toxin, RelE/StbE familyToxin
A0U89_RS1544583718..84980+1263WP_070404149.1sodium:proton antiporter-
A0U89_RS1545084980..85663+684WP_029604387.1DUF1275 domain-containing protein-
A0U89_RS1545586102..86812+711WP_147061376.1hypothetical protein-
A0U89_RS1546087017..87790-774WP_070404151.1HNH endonuclease-

Associated MGEs

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MGE
detail
Similar
MGEs
Relative
position
MGE Type
Cargo ARG
Virulence gene
Coordinates
Length (bp)
-insideNon-Mobilizable plasmid--1..102455102455


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(6-86)

Antitoxin

RelB antitoxin/Antitoxin DinJ

(1-80)


Sequences

Toxin        


Download         Length: 98 a.a.        Molecular weight: 11605.35 Da        Isoelectric Point: 7.9998

>T61685 WP_003618711.1 NZ_CP014676:83293-83586 [Kozakia baliensis]
MKEYCLEFDDRALREWDALDGSVRKKFEKKLEKLIWNPHSPGNELHRDLSGFYKIKLLKDGYRLVYQVIDERIVIYVIAV
GRRADNEIYELASKRTE

Download         Length: 294 bp

>T61685 NZ_CP014676:83293-83586 [Kozakia baliensis]
ATGAAAGAGTATTGTCTTGAATTCGACGACAGAGCACTCAGAGAGTGGGATGCTCTTGACGGCAGCGTGCGTAAGAAATT
TGAAAAGAAGCTGGAAAAGCTGATCTGGAACCCTCACTCTCCAGGAAACGAACTGCATCGCGACCTATCAGGGTTTTATA
AGATCAAGCTTCTGAAAGATGGTTACCGCCTTGTTTATCAGGTCATCGACGAACGGATCGTCATCTATGTAATTGCCGTT
GGCCGGAGAGCCGATAATGAGATTTATGAACTGGCTTCGAAGCGAACAGAGTGA

Antitoxin


Download         Length: 87 a.a.        Molecular weight: 9762.23 Da        Isoelectric Point: 10.4645

>AT61685 WP_003618686.1 NZ_CP014676:83036-83296 [Kozakia baliensis]
MSAVTFRVDETLKAAAVKKLSAQGISLSDALRDTLAYIAETGRSPVKRRLVTDEDAELIEIVRERLKNPAQKHRMTFAEL
KNRHRE

Download         Length: 261 bp

>AT61685 NZ_CP014676:83036-83296 [Kozakia baliensis]
ATGTCTGCTGTTACATTCCGGGTAGATGAAACGCTGAAGGCAGCCGCAGTTAAGAAGTTGTCGGCTCAAGGCATTTCACT
TTCTGACGCACTGCGCGATACGCTCGCGTATATTGCTGAAACGGGTCGCTCTCCCGTCAAGCGGAGGCTTGTCACAGACG
AGGATGCGGAGCTTATCGAGATTGTGCGCGAACGCCTAAAAAACCCTGCCCAAAAGCATCGTATGACTTTTGCAGAGCTT
AAGAACCGTCATCGCGAATGA

Similar Proteins

Only experimentally validated proteins are listed.

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Protein
Organism
Identities (%)
Coverage (%)
Ha-value
No matching records found
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Protein
Organism
Identities (%)
Coverage (%)
Ha-value
No matching records found

Structures

Toxin

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Source
ID
Structure
No matching records found

Antitoxin

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Source
ID
Structure
AlphaFold DBA0A6N3T9M6

References