Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) mazEF/PemK-PrlF
Location 2224260..2224815 Replicon chromosome
Accession NZ_CP014671
Organism Immundisolibacter cernigliae strain TR3.2

Toxin (Protein)


Gene name mazF Uniprot ID A0A1B1YV12
Locus tag PG2T_RS10590 Protein ID WP_068805051.1
Coordinates 2224465..2224815 (+) Length 117 a.a.

Antitoxin (Protein)


Gene name mazE Uniprot ID A0A1B1YUX1
Locus tag PG2T_RS10585 Protein ID WP_068805048.1
Coordinates 2224260..2224478 (+) Length 73 a.a.

Genomic Context

PG2T_RS10555PG2T_RS10560PG2T_RS10565PG2T_RS10570PG2T_RS10575PG2T_RS15555PG2T_RS10585PG2T_RS10590PG2T_RS10605PG2T_RS10610PG2T_RS10595PG2T_RS10600
Location: 2220605..2220862 (258 bp)
Type: Others
Protein ID: WP_068805034.1
Location: 2220859..2221158 (300 bp)
Type: Others
Protein ID: WP_068805036.1
Location: 2221297..2222001 (705 bp)
Type: Others
Protein ID: WP_068805039.1
Location: 2222108..2222347 (240 bp)
Type: Others
Protein ID: WP_068805041.1
Location: 2222335..2222649 (315 bp)
Type: Others
Protein ID: WP_068805044.1
Location: 2222850..2223680 (831 bp)
Type: Others
Protein ID: WP_075968172.1
Location: 2224260..2224478 (219 bp)
Type: Antitoxin
Protein ID: WP_068805048.1
Location: 2224465..2224815 (351 bp)
Type: Toxin
Protein ID: WP_068805051.1
Location: 2227912..2228175 (264 bp)
Type: Others
Protein ID: WP_068805060.1
Location: 2228299..2228898 (600 bp)
Type: Others
Protein ID: WP_068805063.1
Location: 2224924..2226480 (1557 bp)
Type: Others
Protein ID: WP_068805054.1
Location: 2226518..2227774 (1257 bp)
Type: Others
Protein ID: WP_202816317.1
ToxinAntitoxinOther genes
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Locus tag
Coordinates
Strand
Size (bp)
Protein ID
Product
Description
PG2T_RS105552220605..2220862+258WP_068805034.1type II toxin-antitoxin system ParD family antitoxin-
PG2T_RS105602220859..2221158+300WP_068805036.1type II toxin-antitoxin system RelE/ParE family toxin-
PG2T_RS105652221297..2222001+705WP_068805039.1DsbA family protein-
PG2T_RS105702222108..2222347+240WP_068805041.1AbrB/MazE/SpoVT family DNA-binding domain-containing protein-
PG2T_RS105752222335..2222649+315WP_068805044.1type II toxin-antitoxin system PemK/MazF family toxin-
PG2T_RS155552222850..2223680+831WP_075968172.1arsenate reductase (glutaredoxin)-
PG2T_RS105852224260..2224478+219WP_068805048.1type II toxin-antitoxin system PrlF family antitoxinAntitoxin
PG2T_RS105902224465..2224815+351WP_068805051.1type II toxin-antitoxin system PemK/MazF family toxinToxin
PG2T_RS105952224924..2226480-1557WP_068805054.1GNAT family N-acetyltransferase-
PG2T_RS106002226518..2227774-1257WP_202816317.1MFS transporter-
PG2T_RS106052227912..2228175+264WP_068805060.1hypothetical protein-
PG2T_RS106102228299..2228898+600WP_068805063.1TIGR00645 family protein-

Associated MGEs

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MGE
detail
Similar
MGEs
Relative
position
MGE Type
Cargo ARG
Virulence gene
Coordinates
Length (bp)
No matching records found


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

mRNA interferase PemK-like

(5-109)

Antitoxin

PrlF antitoxin

(4-53)


Sequences

Toxin        


Download         Length: 117 a.a.        Molecular weight: 12258.16 Da        Isoelectric Point: 10.7876

>T61683 WP_068805051.1 NZ_CP014671:2224465-2224815 [Immundisolibacter cernigliae]
MPTFRQGDVIKVPFPYTDRSTRQSRPALVVSAGSLEEAHGLLWVVMITSAQNRGWPGDVPVGNLAAAGLPVPSVIRAAKI
ATIEATDASRLGTVAPAVFRRVAQCLANQLGLDARP

Download         Length: 351 bp

>T61683 NZ_CP014671:2224465-2224815 [Immundisolibacter cernigliae]
ATGCCGACCTTTAGGCAGGGCGACGTCATCAAGGTGCCGTTTCCGTACACGGACCGCTCCACCCGGCAGTCCAGGCCAGC
ACTGGTGGTGTCGGCCGGCAGCCTCGAAGAGGCCCACGGACTGCTGTGGGTGGTCATGATCACCAGCGCTCAGAACCGGG
GATGGCCGGGCGACGTGCCGGTGGGCAATCTTGCGGCAGCCGGCCTACCGGTGCCGTCCGTGATCCGGGCCGCGAAAATC
GCCACCATCGAAGCGACGGACGCGTCCAGGTTGGGTACTGTGGCCCCCGCGGTATTCCGACGGGTGGCCCAATGTCTGGC
CAATCAGCTTGGTCTGGACGCCCGACCGTGA

Antitoxin


Download         Length: 73 a.a.        Molecular weight: 8123.10 Da        Isoelectric Point: 4.5238

>AT61683 WP_068805048.1 NZ_CP014671:2224260-2224478 [Immundisolibacter cernigliae]
MISSKLTSKAQTTIPQPVRVALHLEPGDELVYEIDDQRVILTKAKTSDRADDPFRTFQEWSTEADAKAYADL

Download         Length: 219 bp

>AT61683 NZ_CP014671:2224260-2224478 [Immundisolibacter cernigliae]
ATGATCAGCAGCAAACTGACCAGCAAAGCGCAGACGACCATCCCGCAACCCGTTCGTGTTGCCCTGCACCTGGAGCCAGG
CGACGAATTGGTCTACGAGATTGATGATCAGCGCGTGATTCTTACCAAGGCCAAAACCAGCGACAGGGCTGACGATCCAT
TCCGCACGTTTCAGGAGTGGAGCACCGAAGCGGACGCGAAGGCTTATGCCGACCTTTAG

Similar Proteins

Only experimentally validated proteins are listed.

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Protein
Organism
Identities (%)
Coverage (%)
Ha-value
No matching records found
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Protein
Organism
Identities (%)
Coverage (%)
Ha-value
No matching records found

Structures

Toxin

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Source
ID
Structure
AlphaFold DBA0A1B1YV12

Antitoxin

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Source
ID
Structure
AlphaFold DBA0A1B1YUX1

References