Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) tacAT/DUF1778(antitoxin)
Location 903177..903955 Replicon chromosome
Accession NZ_CP014671
Organism Immundisolibacter cernigliae strain TR3.2

Toxin (Protein)


Gene name tacT Uniprot ID A0A1B1YS00
Locus tag PG2T_RS04250 Protein ID WP_068802975.1
Coordinates 903452..903955 (+) Length 168 a.a.

Antitoxin (Protein)


Gene name tacA Uniprot ID A0A1B1YRP2
Locus tag PG2T_RS04245 Protein ID WP_068802974.1
Coordinates 903177..903455 (+) Length 93 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
PG2T_RS04210 898622..899149 - 528 WP_068802967.1 RES family NAD+ phosphorylase -
PG2T_RS04215 899146..899517 - 372 WP_068802968.1 DNA-binding protein -
PG2T_RS04220 900187..900447 + 261 WP_202816418.1 type II toxin-antitoxin system Phd/YefM family antitoxin -
PG2T_RS04225 900437..900853 + 417 WP_068802970.1 putative toxin-antitoxin system toxin component, PIN family -
PG2T_RS04230 900903..901745 + 843 WP_068802971.1 glycosyltransferase -
PG2T_RS04235 902201..902431 - 231 WP_068802972.1 DUF433 domain-containing protein -
PG2T_RS15410 902461..902664 - 204 WP_202816419.1 type II toxin-antitoxin system HicB family antitoxin -
PG2T_RS16230 902813..902962 - 150 WP_158513147.1 hypothetical protein -
PG2T_RS04245 903177..903455 + 279 WP_068802974.1 DUF1778 domain-containing protein Antitoxin
PG2T_RS04250 903452..903955 + 504 WP_068802975.1 GNAT family N-acetyltransferase Toxin
PG2T_RS04255 904247..905455 - 1209 WP_068802976.1 metal-dependent hydrolase -
PG2T_RS04260 905626..906069 + 444 WP_068802977.1 NfeD family protein -
PG2T_RS04265 906112..906966 + 855 WP_068802978.1 paraslipin -
PG2T_RS04270 907172..907459 + 288 WP_068802979.1 DUF1778 domain-containing protein -
PG2T_RS04275 907462..907758 + 297 WP_068802980.1 type II toxin-antitoxin system RelE/ParE family toxin -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

GNAT domain

(41-142)

Antitoxin

Vibrio phage ICP1, Orf50

(6-88)


Sequences

Toxin        


Download         Length: 168 a.a.        Molecular weight: 18430.17 Da        Isoelectric Point: 8.1328

>T61682 WP_068802975.1 NZ_CP014671:903452-903955 [Immundisolibacter cernigliae]
MSNGYAPVRKLAATDQTDAFDCGQAALNQFLQRYALVNQKANSAQTYVCCQGDVVVGFYSLAVGSVDPDAAPSRVMKGLA
RHPVPVMILARLAVDREHQRKGLGQALLKDALLRTAQAADIAGIRCLLVHAKDDAARRWYESWEFEPSPTDPYHLFLMLK
DLRSLLN

Download         Length: 504 bp

>T61682 NZ_CP014671:903452-903955 [Immundisolibacter cernigliae]
TTGAGCAATGGCTACGCACCCGTTCGCAAGCTTGCAGCCACGGATCAAACCGATGCCTTCGACTGCGGCCAGGCCGCGCT
GAACCAGTTCCTGCAGCGCTACGCGCTCGTCAACCAGAAGGCCAACAGCGCGCAGACCTACGTCTGCTGCCAGGGTGACG
TGGTGGTCGGCTTCTACAGCCTCGCCGTCGGCAGCGTCGATCCGGATGCCGCGCCGTCGAGGGTGATGAAGGGGCTGGCG
CGTCACCCGGTGCCGGTGATGATCTTGGCCCGGCTCGCAGTGGACAGGGAGCATCAGCGCAAAGGCCTGGGTCAAGCTTT
GCTCAAGGATGCACTGCTACGCACGGCCCAGGCCGCCGACATCGCCGGCATTCGCTGCCTGCTGGTGCACGCCAAGGATG
ATGCGGCGCGGCGCTGGTACGAGTCCTGGGAATTCGAGCCCAGCCCGACCGATCCGTACCACCTGTTCCTGATGCTCAAG
GATCTGAGGAGTTTGTTGAACTGA

Antitoxin


Download         Length: 93 a.a.        Molecular weight: 10159.62 Da        Isoelectric Point: 8.0238

>AT61682 WP_068802974.1 NZ_CP014671:903177-903455 [Immundisolibacter cernigliae]
MSTLNLSKTERIDVRASAPVKQLLQEAARACHKNVSEFLLDAGVTAAAQTLADRRQFVLDEAQWQAFQEALDRSVQGKPR
LKKLLDEPGVLG

Download         Length: 279 bp

>AT61682 NZ_CP014671:903177-903455 [Immundisolibacter cernigliae]
ATGAGCACGCTGAATCTTTCCAAGACTGAGCGCATCGACGTCCGTGCAAGCGCGCCGGTCAAGCAGCTGCTGCAGGAAGC
GGCGCGCGCCTGCCACAAGAACGTCAGCGAGTTCCTGCTCGACGCAGGCGTGACGGCTGCGGCGCAGACGCTGGCGGATC
GTCGCCAGTTCGTGCTGGACGAGGCGCAGTGGCAGGCGTTCCAGGAAGCGCTGGATCGGTCGGTGCAAGGCAAGCCGCGC
CTGAAGAAGCTGCTGGATGAGCCCGGGGTGCTCGGTTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A1B1YS00

Antitoxin

Source ID Structure
AlphaFold DB A0A1B1YRP2

References