Detailed information of TA system
Overview
TA module
| Type | II | Classification (family/domain) | slvAT/RES(toxin) |
| Location | 898622..899517 | Replicon | chromosome |
| Accession | NZ_CP014671 | ||
| Organism | Immundisolibacter cernigliae strain TR3.2 | ||
Toxin (Protein)
| Gene name | slvT | Uniprot ID | A0A1B1YRS7 |
| Locus tag | PG2T_RS04210 | Protein ID | WP_068802967.1 |
| Coordinates | 898622..899149 (-) | Length | 176 a.a. |
Antitoxin (Protein)
| Gene name | slvA | Uniprot ID | A0A1B1YRW0 |
| Locus tag | PG2T_RS04215 | Protein ID | WP_068802968.1 |
| Coordinates | 899146..899517 (-) | Length | 124 a.a. |
Genomic Context
| Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
|---|---|---|---|---|---|---|
| PG2T_RS15400 | 894105..895034 | + | 930 | WP_075968137.1 | glycosyltransferase | - |
| PG2T_RS04195 | 895155..896060 | + | 906 | WP_158513146.1 | glycosyltransferase family 4 protein | - |
| PG2T_RS15405 | 896270..896983 | - | 714 | WP_075968138.1 | class I SAM-dependent methyltransferase | - |
| PG2T_RS04200 | 897410..897589 | - | 180 | WP_202816416.1 | type II toxin-antitoxin system HicB family antitoxin | - |
| PG2T_RS04205 | 897638..897964 | + | 327 | WP_202816417.1 | glycosyltransferase family 4 protein | - |
| PG2T_RS04210 | 898622..899149 | - | 528 | WP_068802967.1 | RES family NAD+ phosphorylase | Toxin |
| PG2T_RS04215 | 899146..899517 | - | 372 | WP_068802968.1 | DNA-binding protein | Antitoxin |
| PG2T_RS04220 | 900187..900447 | + | 261 | WP_202816418.1 | type II toxin-antitoxin system Phd/YefM family antitoxin | - |
| PG2T_RS04225 | 900437..900853 | + | 417 | WP_068802970.1 | putative toxin-antitoxin system toxin component, PIN family | - |
| PG2T_RS04230 | 900903..901745 | + | 843 | WP_068802971.1 | glycosyltransferase | - |
| PG2T_RS04235 | 902201..902431 | - | 231 | WP_068802972.1 | DUF433 domain-containing protein | - |
| PG2T_RS15410 | 902461..902664 | - | 204 | WP_202816419.1 | type II toxin-antitoxin system HicB family antitoxin | - |
| PG2T_RS16230 | 902813..902962 | - | 150 | WP_158513147.1 | hypothetical protein | - |
| PG2T_RS04245 | 903177..903455 | + | 279 | WP_068802974.1 | DUF1778 domain-containing protein | - |
| PG2T_RS04250 | 903452..903955 | + | 504 | WP_068802975.1 | GNAT family N-acetyltransferase | - |
Associated MGEs
| MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
|---|---|---|---|---|---|---|---|
| - | inside | Genomic island | - | - | 883809..901745 | 17936 |
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 176 a.a. Molecular weight: 19736.18 Da Isoelectric Point: 6.3306
>T61681 WP_068802967.1 NZ_CP014671:c899149-898622 [Immundisolibacter cernigliae]
MILLDLPPGTTLYRAHTPQWASRPTSGAGAAAKGGRFNREGVEALYLSLDEVTALREYQQTSPFLPPCTMCSYTVALRGL
VDLRQLRRGEPWDALWHDWREDWRHLKFDLHIEPPTWVLGDMVLAQGHTGILFPSQANDGGTNAVVYVDRLRDGNSVEVN
DPNGRLPRDQSSWNR
MILLDLPPGTTLYRAHTPQWASRPTSGAGAAAKGGRFNREGVEALYLSLDEVTALREYQQTSPFLPPCTMCSYTVALRGL
VDLRQLRRGEPWDALWHDWREDWRHLKFDLHIEPPTWVLGDMVLAQGHTGILFPSQANDGGTNAVVYVDRLRDGNSVEVN
DPNGRLPRDQSSWNR
Download Length: 528 bp
>T61681 NZ_CP014671:c899149-898622 [Immundisolibacter cernigliae]
ATGATCCTCCTCGACCTGCCGCCCGGTACCACGCTGTATCGCGCGCATACCCCGCAGTGGGCCAGCCGGCCCACCAGCGG
CGCCGGTGCGGCGGCCAAGGGCGGGCGCTTCAACCGGGAGGGCGTCGAGGCGCTGTATCTGTCGCTGGATGAGGTGACCG
CATTGCGCGAGTACCAGCAAACCTCGCCGTTCCTGCCGCCCTGCACGATGTGCTCGTACACCGTGGCGTTGCGCGGGCTG
GTCGATCTGCGGCAGCTCCGCCGCGGCGAGCCTTGGGACGCGCTGTGGCACGACTGGCGCGAGGACTGGCGCCATCTGAA
ATTCGACCTGCACATCGAGCCGCCCACCTGGGTGCTGGGCGACATGGTGCTGGCCCAGGGCCACACCGGCATCCTGTTCC
CCAGCCAGGCGAACGACGGCGGCACCAATGCCGTGGTGTACGTGGATCGGCTCAGGGACGGCAATTCGGTCGAGGTCAAT
GATCCCAACGGGCGACTGCCCCGCGACCAATCCAGTTGGAACCGCTGA
ATGATCCTCCTCGACCTGCCGCCCGGTACCACGCTGTATCGCGCGCATACCCCGCAGTGGGCCAGCCGGCCCACCAGCGG
CGCCGGTGCGGCGGCCAAGGGCGGGCGCTTCAACCGGGAGGGCGTCGAGGCGCTGTATCTGTCGCTGGATGAGGTGACCG
CATTGCGCGAGTACCAGCAAACCTCGCCGTTCCTGCCGCCCTGCACGATGTGCTCGTACACCGTGGCGTTGCGCGGGCTG
GTCGATCTGCGGCAGCTCCGCCGCGGCGAGCCTTGGGACGCGCTGTGGCACGACTGGCGCGAGGACTGGCGCCATCTGAA
ATTCGACCTGCACATCGAGCCGCCCACCTGGGTGCTGGGCGACATGGTGCTGGCCCAGGGCCACACCGGCATCCTGTTCC
CCAGCCAGGCGAACGACGGCGGCACCAATGCCGTGGTGTACGTGGATCGGCTCAGGGACGGCAATTCGGTCGAGGTCAAT
GATCCCAACGGGCGACTGCCCCGCGACCAATCCAGTTGGAACCGCTGA
Antitoxin
Download Length: 124 a.a. Molecular weight: 13370.06 Da Isoelectric Point: 5.5562
>AT61681 WP_068802968.1 NZ_CP014671:c899517-899146 [Immundisolibacter cernigliae]
MASTAFADVLESVREAGTSRFSATNVADALGLQYQELAALAGVHRNTLRTHPESPRLQDALRDLMRVLSAATAVQPDTAR
AFFMVKNEPIPAFHHKTLLQLVQEGRTDDAIDYLESISAGFTG
MASTAFADVLESVREAGTSRFSATNVADALGLQYQELAALAGVHRNTLRTHPESPRLQDALRDLMRVLSAATAVQPDTAR
AFFMVKNEPIPAFHHKTLLQLVQEGRTDDAIDYLESISAGFTG
Download Length: 372 bp
>AT61681 NZ_CP014671:c899517-899146 [Immundisolibacter cernigliae]
ATGGCCTCTACCGCTTTCGCTGATGTGCTCGAATCGGTACGTGAAGCCGGCACGTCCCGCTTTTCCGCCACGAACGTCGC
CGATGCCTTGGGTCTGCAGTACCAGGAACTGGCAGCGCTGGCTGGCGTGCACCGCAACACCCTGCGCACCCACCCCGAGT
CACCGCGACTCCAAGACGCGCTGCGTGACCTGATGCGGGTGCTGTCGGCCGCCACGGCGGTGCAGCCGGATACCGCGCGT
GCATTCTTCATGGTCAAGAACGAGCCCATACCGGCGTTCCACCACAAGACCCTGCTGCAGTTGGTGCAGGAAGGACGCAC
CGACGATGCGATCGACTACCTGGAGTCGATCAGTGCGGGGTTCACCGGATGA
ATGGCCTCTACCGCTTTCGCTGATGTGCTCGAATCGGTACGTGAAGCCGGCACGTCCCGCTTTTCCGCCACGAACGTCGC
CGATGCCTTGGGTCTGCAGTACCAGGAACTGGCAGCGCTGGCTGGCGTGCACCGCAACACCCTGCGCACCCACCCCGAGT
CACCGCGACTCCAAGACGCGCTGCGTGACCTGATGCGGGTGCTGTCGGCCGCCACGGCGGTGCAGCCGGATACCGCGCGT
GCATTCTTCATGGTCAAGAACGAGCCCATACCGGCGTTCCACCACAAGACCCTGCTGCAGTTGGTGCAGGAAGGACGCAC
CGACGATGCGATCGACTACCTGGAGTCGATCAGTGCGGGGTTCACCGGATGA
Similar Proteins
Only experimentally validated proteins are listed.
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
Structures
Toxin
| Source | ID | Structure |
|---|---|---|
| AlphaFold DB | A0A1B1YRS7 |
Antitoxin
| Source | ID | Structure |
|---|---|---|
| AlphaFold DB | A0A1B1YRW0 |