Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) pasABC/RelE-HTH
Location 339300..339777 Replicon chromosome
Accession NZ_CP014671
Organism Immundisolibacter cernigliae strain TR3.2

Toxin (Protein)


Gene name pasB Uniprot ID A0A1B1YQL2
Locus tag PG2T_RS01620 Protein ID WP_068802528.1
Coordinates 339300..339566 (-) Length 89 a.a.

Antitoxin (Protein)


Gene name pasA Uniprot ID A0A1B1YQG4
Locus tag PG2T_RS01625 Protein ID WP_068802529.1
Coordinates 339550..339777 (-) Length 76 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
PG2T_RS01600 335103..336029 - 927 WP_068802524.1 hydroxyacid dehydrogenase -
PG2T_RS01605 336036..337046 - 1011 WP_068802525.1 2-dehydropantoate 2-reductase -
PG2T_RS01610 337344..337682 - 339 WP_068802526.1 P-II family nitrogen regulator -
PG2T_RS01615 337771..338682 + 912 WP_068802527.1 tRNA glutamyl-Q(34) synthetase GluQRS -
PG2T_RS01620 339300..339566 - 267 WP_068802528.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
PG2T_RS01625 339550..339777 - 228 WP_068802529.1 TraY domain-containing protein Antitoxin
PG2T_RS01630 340115..340324 + 210 WP_068802530.1 DUF2281 domain-containing protein -
PG2T_RS01635 340311..340646 + 336 WP_068802531.1 type II toxin-antitoxin system PemK/MazF family toxin -
PG2T_RS01640 341119..341520 - 402 WP_068802532.1 PIN domain-containing protein -
PG2T_RS01645 341517..341741 - 225 WP_068807535.1 AbrB family transcriptional regulator -
PG2T_RS01650 342069..342380 - 312 WP_068802533.1 type II toxin-antitoxin system RelE/ParE family toxin -
PG2T_RS01655 342385..342654 - 270 WP_068802534.1 type II toxin-antitoxin system Phd/YefM family antitoxin -
PG2T_RS01660 343280..343579 + 300 WP_068802535.1 nucleotidyltransferase domain-containing protein -
PG2T_RS01665 343576..344076 + 501 WP_068802536.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(6-87)

Antitoxin

Relaxosome protein TraY

(5-46)


Sequences

Toxin        


Download         Length: 89 a.a.        Molecular weight: 10006.53 Da        Isoelectric Point: 10.1004

>T61679 WP_068802528.1 NZ_CP014671:c339566-339300 [Immundisolibacter cernigliae]
MAWTIDYTGTARKQLLKLDKQTARRIVDFMDARVAPADDPRSTGRALSGPLGGFWRYRVGDCRVICDIQDGALRVLVVDI
GHRREVYR

Download         Length: 267 bp

>T61679 NZ_CP014671:c339566-339300 [Immundisolibacter cernigliae]
TTGGCCTGGACGATTGACTACACGGGCACGGCCAGAAAGCAACTGCTCAAGCTCGACAAGCAAACAGCCCGGCGCATCGT
CGATTTCATGGACGCACGGGTTGCGCCCGCGGATGATCCTCGCAGCACCGGCAGGGCGCTGAGCGGTCCGCTGGGCGGAT
TCTGGCGTTATCGCGTCGGTGACTGCCGCGTCATTTGCGACATTCAGGATGGCGCTCTGCGGGTGCTGGTGGTGGACATC
GGTCACCGGCGCGAGGTTTACCGCTGA

Antitoxin


Download         Length: 76 a.a.        Molecular weight: 8570.58 Da        Isoelectric Point: 4.8359

>AT61679 WP_068802529.1 NZ_CP014671:c339777-339550 [Immundisolibacter cernigliae]
VATSIRLDAKTEQRLHSLSVRTGRSKAFYLRQIIEKGLEDVEDYYLAADVVERVRAGQEEVYSAEQVRKDLGLDD

Download         Length: 228 bp

>AT61679 NZ_CP014671:c339777-339550 [Immundisolibacter cernigliae]
GTGGCCACTTCAATTCGCCTGGACGCGAAAACCGAGCAGCGCCTGCACTCTCTGTCCGTGCGTACCGGGCGCAGCAAAGC
CTTCTACCTGCGTCAGATCATCGAGAAGGGACTGGAAGACGTAGAGGACTACTACCTCGCCGCGGATGTGGTCGAGCGCG
TCCGCGCGGGCCAGGAGGAGGTCTACTCCGCCGAGCAGGTGAGAAAAGACCTTGGCCTGGACGATTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A1B1YQL2

Antitoxin

Source ID Structure
AlphaFold DB A0A1B1YQG4

References