Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type IV Classification (family/domain) yeeUV (cbtA-cbeA)/CbtA-CbeA
Location 366122..366957 Replicon chromosome
Accession NZ_CP014667
Organism Escherichia coli strain ECONIH2

Toxin (Protein)


Gene name yeeV Uniprot ID Q83W73
Locus tag WM48_RS01725 Protein ID WP_000854700.1
Coordinates 366580..366957 (+) Length 126 a.a.

Antitoxin (Protein)


Gene name yeeU Uniprot ID E3PJ72
Locus tag WM48_RS01720 Protein ID WP_001278232.1
Coordinates 366122..366490 (+) Length 123 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
WM48_RS01695 363782..364600 + 819 WP_001234709.1 DUF945 domain-containing protein -
WM48_RS01700 364692..365177 + 486 WP_000213723.1 antirestriction protein -
WM48_RS01705 365193..365669 + 477 WP_001186199.1 RadC family protein -
WM48_RS01710 365738..365959 + 222 WP_000692353.1 DUF987 domain-containing protein -
WM48_RS01720 366122..366490 + 369 WP_001278232.1 type IV toxin-antitoxin system toxin CbtA Antitoxin
WM48_RS01725 366580..366957 + 378 WP_000854700.1 TA system toxin CbtA family protein Toxin
WM48_RS01730 366954..367442 + 489 WP_000761726.1 hypothetical protein -
WM48_RS01735 367454..367651 + 198 WP_000839247.1 DUF957 domain-containing protein -
WM48_RS01740 367736..368590 + 855 WP_024174313.1 DUF4942 domain-containing protein -
WM48_RS01745 368683..370002 - 1320 WP_000144686.1 site-specific integrase -
WM48_RS01750 370368..370706 + 339 WP_000772639.1 Arm DNA-binding domain-containing protein -
WM48_RS01755 371141..371635 - 495 WP_001059463.1 MarR family transcriptional regulator -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Genomic island - vat / yagV/ecpE / yagW/ecpD / yagX/ecpC / yagY/ecpB / yagZ/ecpA / ykgK/ecpR / fdeC 340389..415936 75547


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

CbtA toxin of type IV toxin-antitoxin system

(1-112)

Antitoxin

Antitoxin CbeA

(18-117)


Sequences

Toxin        


Download         Length: 126 a.a.        Molecular weight: 14276.28 Da        Isoelectric Point: 7.8046

>T61648 WP_000854700.1 NZ_CP014667:366580-366957 [Escherichia coli]
MKTLPDTHVREASRCLSPVEIWQTLLTRLLDQHYGLTLNDTPFADERVIEQHIEAGISLCDAVNFLVEKYALVRTDQPGF
SPCTRSQLINSIDILRARRATGLMTRDNYRTVNNITRGKHPEAKQ

Download         Length: 378 bp

>T61648 NZ_CP014667:366580-366957 [Escherichia coli]
ATGAAAACATTACCCGACACACACGTACGGGAGGCATCGCGCTGCCTGTCTCCGGTTGAAATCTGGCAGACACTGCTCAC
CCGGTTACTGGACCAGCACTACGGCCTCACACTGAATGACACACCGTTCGCTGATGAACGTGTGATTGAGCAGCATATTG
AAGCAGGGATTTCACTGTGTGACGCGGTGAACTTTCTCGTTGAAAAATACGCCCTGGTGCGTACCGACCAGCCGGGATTC
AGCCCCTGTACCCGCTCTCAGTTAATCAACAGTATCGATATCCTCCGGGCACGCCGGGCAACCGGCCTGATGACCCGCGA
TAACTACAGAACGGTAAATAACATTACCCGGGGTAAGCATCCGGAGGCGAAACAATGA

Antitoxin


Download         Length: 123 a.a.        Molecular weight: 13491.37 Da        Isoelectric Point: 6.6290

>AT61648 WP_001278232.1 NZ_CP014667:366122-366490 [Escherichia coli]
VSDALSGTMLPDDNHDRPWWGLPCTVTPCFGARLVQEGNRLHYLADRAGIRGLFSDADAYHLDQAFPLLMKQLELMLTSG
ELNPRHQHTVTLYAKGLTCKADTLGSGGYVYLAVYPTPETKK

Download         Length: 369 bp

>AT61648 NZ_CP014667:366122-366490 [Escherichia coli]
GTGTCAGACGCACTCTCCGGGACAATGCTTCCCGACGACAATCACGACCGCCCCTGGTGGGGGCTGCCCTGCACCGTGAC
GCCCTGTTTCGGGGCACGTCTGGTGCAGGAGGGTAACCGCCTGCATTACCTTGCCGACCGCGCCGGTATCAGAGGCCTGT
TCAGCGATGCAGATGCGTACCACCTGGACCAGGCCTTTCCGCTGCTGATGAAACAACTGGAACTCATGCTCACCAGCGGT
GAACTGAATCCCCGCCATCAGCATACCGTCACGCTGTATGCAAAAGGTCTGACCTGCAAAGCTGACACTCTCGGTAGCGG
TGGTTACGTTTATCTGGCTGTTTATCCGACGCCCGAAACGAAAAAGTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A454A1I2

Antitoxin

Source ID Structure
AlphaFold DB E3PJ72

References