Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) parDE/RelE-RHH
Location 2395..2942 Replicon plasmid pSAN1-2010K-2577
Accession NZ_CP014662
Organism Salmonella enterica subsp. enterica serovar Anatum str. USDA-ARS-USMARC-1783

Toxin (Protein)


Gene name parE Uniprot ID E9LLH3
Locus tag AW46_RS22635 Protein ID WP_000969996.1
Coordinates 2661..2942 (+) Length 94 a.a.

Antitoxin (Protein)


Gene name parD Uniprot ID E1QMW3
Locus tag AW46_RS22630 Protein ID WP_000079941.1
Coordinates 2395..2664 (+) Length 90 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
AW46_RS22625 455..1486 + 1032 WP_000907875.1 replication initiation protein -
AW46_RS22630 2395..2664 + 270 WP_000079941.1 hypothetical protein Antitoxin
AW46_RS22635 2661..2942 + 282 WP_000969996.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
AW46_RS22640 2982..3830 + 849 WP_001057996.1 3'-5' exonuclease -
AW46_RS25665 4067..4225 - 159 WP_197711125.1 MerR family transcriptional regulator -
AW46_RS22645 4187..5797 + 1611 Protein_5 DDE-type integrase/transposase/recombinase -
AW46_RS22650 5800..6660 + 861 WP_000344784.1 TniB family NTP-binding protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Non-Mobilizable plasmid - - 1..103851 103851


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

CbtA toxin of type IV toxin-antitoxin system

(1-108)

Antitoxin

Antitoxin CbeA

(5-104)


Sequences

Toxin        


Download         Length: 94 a.a.        Molecular weight: 12066.38 Da        Isoelectric Point: 12.7685

>T61643 WP_000969996.1 NZ_CP014662:2661-2942 [Salmonella enterica subsp. enterica serovar Anatum str.]
KKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKK
KKKKKKKKKKKKKK

Download         Length: 282 bp

>T61643 NZ_CP014662:2661-2942 [Salmonella enterica subsp. enterica serovar Anatum str.]
AAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAA
AAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAA
AAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAA
AAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAA

Antitoxin


Download         Length: 90 a.a.        Molecular weight: 11553.68 Da        Isoelectric Point: 12.7493

>AT61643 WP_000079941.1 NZ_CP014662:2395-2664 [Salmonella enterica subsp. enterica serovar Anatum str.]
KKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKK
KKKKKKKKKK

Download         Length: 270 bp

>AT61643 NZ_CP014662:2395-2664 [Salmonella enterica subsp. enterica serovar Anatum str.]
AAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAA
AAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAA
AAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAA
AAAAAAAAAAAAAAAAAAAAAAAAAAAAAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB E9LLH3

Antitoxin

Source ID Structure
AlphaFold DB A0A629TXC5

References