61636

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type IV Classification (family/domain) cptAB/Cpta(toxin)
Location 4487156..4487813 Replicon chromosome
Accession NZ_CP014647
Organism Klebsiella pneumoniae strain KPNIH36

Toxin (Protein)


Gene name cptA Uniprot ID W8UCT0
Locus tag ABA76_RS22645 Protein ID WP_002916310.1
Coordinates 4487156..4487566 (-) Length 137 a.a.

Antitoxin (Protein)


Gene name cptB Uniprot ID W8UQ37
Locus tag ABA76_RS22650 Protein ID WP_002916312.1
Coordinates 4487547..4487813 (-) Length 89 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
ABA76_RS22625 4483156..4484889 - 1734 WP_004151783.1 single-stranded-DNA-specific exonuclease RecJ -
ABA76_RS22630 4484895..4485608 - 714 WP_002916301.1 bifunctional protein-disulfide isomerase/oxidoreductase DsbC -
ABA76_RS22635 4485631..4486527 - 897 WP_004144729.1 site-specific tyrosine recombinase XerD -
ABA76_RS22640 4486628..4487149 + 522 WP_002916308.1 flavodoxin FldB -
ABA76_RS22645 4487156..4487566 - 411 WP_002916310.1 protein YgfX Toxin
ABA76_RS22650 4487547..4487813 - 267 WP_002916312.1 FAD assembly factor SdhE Antitoxin
ABA76_RS22655 4488059..4489042 + 984 WP_002916313.1 tRNA-modifying protein YgfZ -
ABA76_RS22660 4489193..4489852 - 660 WP_002916317.1 hemolysin III family protein -
ABA76_RS22665 4490016..4490327 - 312 WP_002916319.1 N(4)-acetylcytidine aminohydrolase -
ABA76_RS22670 4490377..4491105 + 729 WP_002916321.1 MurR/RpiR family transcriptional regulator -
ABA76_RS22675 4491224..4492657 + 1434 WP_002916322.1 6-phospho-beta-glucosidase BglA -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Inner membrane protein YgfX

(3-132)

Antitoxin

Flavinator of succinate dehydrogenase

(7-79)


Sequences

Toxin        


Download         Length: 137 a.a.        Molecular weight: 16049.85 Da        Isoelectric Point: 11.4778

>T61636 WP_002916310.1 NZ_CP014647:c4487566-4487156 [Klebsiella pneumoniae]
VVLWQSDLRISWRAQWFSLLLHGVVAALVLLVPWPLSYTPIWLLLLSLVVFDCVRSQRRIHARRGEIKLLTDSRLRWQNA
EWEILGTPWVINSGMLLRLRHVDTRRGQHLWLAADSMDAGEWRDLRRLVLQKPAQE

Download         Length: 411 bp

>T61636 NZ_CP014647:c4487566-4487156 [Klebsiella pneumoniae]
GTGGTCCTGTGGCAATCTGATCTCCGTATCTCCTGGCGCGCGCAGTGGTTTTCCCTGCTGCTTCACGGCGTGGTGGCGGC
CCTGGTGCTGTTGGTTCCCTGGCCGCTGAGCTATACCCCGATCTGGCTGCTGCTGCTGTCGCTGGTGGTCTTCGACTGCG
TGCGCAGCCAGCGGCGGATCCATGCCCGTCGCGGGGAGATAAAACTGCTCACCGATTCCCGTCTTCGCTGGCAAAACGCC
GAATGGGAAATCCTCGGGACGCCGTGGGTTATCAATAGCGGTATGCTGCTGCGTTTGCGCCATGTCGATACCCGGCGCGG
ACAGCATCTTTGGCTGGCGGCGGACAGCATGGACGCCGGAGAGTGGCGCGATCTGCGCCGGCTGGTGCTGCAAAAACCGG
CGCAGGAGTAA

Antitoxin


Download         Length: 89 a.a.        Molecular weight: 10480.98 Da        Isoelectric Point: 5.1116

>AT61636 WP_002916312.1 NZ_CP014647:c4487813-4487547 [Klebsiella pneumoniae]
MDINNKARIHWACRRGMRELDISIMPFFEYEYDTLSDADKQLFIRLLENDDPDLFNWLMNHGKPADAELQRMVTLIQTRN
RERGPVAI

Download         Length: 267 bp

>AT61636 NZ_CP014647:c4487813-4487547 [Klebsiella pneumoniae]
ATGGACATTAACAATAAAGCACGTATCCACTGGGCATGCCGCCGCGGGATGCGCGAACTCGACATCTCCATCATGCCGTT
CTTTGAGTATGAGTACGATACCCTCAGCGACGCTGACAAACAGCTGTTCATTCGCCTGCTGGAAAATGACGATCCGGATC
TGTTCAACTGGCTGATGAACCACGGCAAACCGGCCGATGCGGAGCTGCAGCGGATGGTAACCTTAATTCAGACACGGAAT
CGGGAACGTGGTCCTGTGGCAATCTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0H3GSW7

Antitoxin

Source ID Structure
AlphaFold DB A0A0H3GY41

References