Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relBE/ParE-YafN
Location 2739515..2740052 Replicon chromosome
Accession NZ_CP014646
Organism Thauera humireducens strain SgZ-1

Toxin (Protein)


Gene name relE Uniprot ID -
Locus tag AC731_RS12860 Protein ID WP_048706621.1
Coordinates 2739750..2740052 (+) Length 101 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID -
Locus tag AC731_RS12855 Protein ID WP_048706619.1
Coordinates 2739515..2739760 (+) Length 82 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
AC731_RS12830 2735678..2736322 - 645 WP_048706615.1 DUF3306 domain-containing protein -
AC731_RS12835 2736319..2736786 - 468 WP_048710105.1 DUF3305 domain-containing protein -
AC731_RS12840 2736945..2737772 + 828 WP_048706616.1 formate dehydrogenase accessory sulfurtransferase FdhD -
AC731_RS12845 2737834..2738472 + 639 WP_205626594.1 molybdenum cofactor guanylyltransferase -
AC731_RS12850 2738480..2739418 + 939 WP_048706617.1 helix-turn-helix transcriptional regulator -
AC731_RS12855 2739515..2739760 + 246 WP_048706619.1 type II toxin-antitoxin system Phd/YefM family antitoxin Antitoxin
AC731_RS12860 2739750..2740052 + 303 WP_048706621.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
AC731_RS12865 2740077..2741420 + 1344 WP_048710111.1 glutathione-disulfide reductase -
AC731_RS12870 2741514..2741816 + 303 WP_048706624.1 nucleotidyltransferase -
AC731_RS19920 2741974..2742096 + 123 Protein_2548 hypothetical protein -
AC731_RS12875 2742136..2742396 + 261 WP_048706627.1 hypothetical protein -
AC731_RS12880 2742619..2742798 + 180 WP_048706629.1 prepilin-type N-terminal cleavage/methylation domain-containing protein -
AC731_RS12885 2743593..2744234 + 642 WP_082794413.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(5-78)

Antitoxin

Type II toxin-antitoxin system, antitoxin Phd/YefM

(9-68)


Sequences

Toxin        


Download         Length: 101 a.a.        Molecular weight: 11711.66 Da        Isoelectric Point: 10.2579

>T61621 WP_048706621.1 NZ_CP014646:2739750-2740052 [Thauera humireducens]
MSYKLRFHSLALAEWRKLDGSLRLQFKKKLEERLITPRVPSSALSGMPDCYKIKLRAVGYRLVYRVDEDVVFVTVISVGL
RDKQRVYSKTHARLDEPEQD

Download         Length: 303 bp

>T61621 NZ_CP014646:2739750-2740052 [Thauera humireducens]
ATGAGCTATAAGCTGCGCTTTCACAGCCTTGCGCTCGCGGAATGGAGAAAGCTCGACGGTAGCCTGCGGCTGCAGTTCAA
GAAGAAGCTCGAAGAGCGCCTGATCACCCCTCGCGTCCCCTCGTCTGCCCTCTCCGGCATGCCAGACTGCTACAAGATCA
AGCTGCGCGCAGTCGGCTACCGCCTGGTCTATCGCGTCGATGAAGACGTGGTGTTCGTGACCGTCATCTCGGTCGGTCTG
CGAGACAAGCAGCGAGTCTATTCAAAGACCCACGCCCGCCTGGATGAGCCAGAGCAGGACTGA

Antitoxin


Download         Length: 82 a.a.        Molecular weight: 9137.32 Da        Isoelectric Point: 4.2942

>AT61621 WP_048706619.1 NZ_CP014646:2739515-2739760 [Thauera humireducens]
MQTIMADLTVSVTELKRNFSSILAQADDSPVAVLNHNRPEAYLISAAHYERLMAYLEDLEDIARVRERSTGPFVEVSLDE
L

Download         Length: 246 bp

>AT61621 NZ_CP014646:2739515-2739760 [Thauera humireducens]
ATGCAGACCATCATGGCCGACCTGACGGTCAGCGTCACCGAACTCAAGCGCAATTTTTCCAGCATCCTCGCGCAAGCGGA
CGACAGCCCGGTGGCCGTGCTCAACCACAACCGCCCCGAGGCCTACCTCATCTCCGCCGCGCACTACGAACGCCTCATGG
CTTACCTGGAAGACCTCGAAGACATCGCGCGCGTGCGCGAGCGCAGCACGGGGCCCTTCGTCGAGGTGAGCCTGGATGAG
CTATAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References