Detailed information of TA system TA061577

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): parDE/ParE-YefM
• Location: 1616862..1617407
• Replicon: chromosome
• Accession: NZ_CP014636
• Organism: Vibrio vulnificus strain CECT 4999

Toxin (Protein)

• Gene name: parE
• Uniprot ID: -
• Locus tag: VVCECT4999_RS08305
• Protein ID: WP_017420806.1
• Coordinates: 1616862..1617158 (-)
• Length: 99 a.a.

Antitoxin (Protein)

• Gene name: parD
• Uniprot ID: D0III5
• Locus tag: VVCECT4999_RS08310
• Protein ID: WP_000557295.1
• Coordinates: 1617165..1617407 (-)
• Length: 81 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
VVCECT4999_RS08250	1611979..1612821	+	843	WP_039452880.1	hypothetical protein	-
VVCECT4999_RS08255	1612973..1613686	+	714	WP_088900043.1	hypothetical protein	-
VVCECT4999_RS08260	1613683..1613829	+	147	WP_080729816.1	DUF3265 domain-containing protein	-
VVCECT4999_RS08265	1613831..1614733	+	903	WP_039453376.1	hypothetical protein	-
VVCECT4999_RS08270	1614748..1614840	+	93	WP_193784075.1	DUF3265 domain-containing protein	-
VVCECT4999_RS08275	1614908..1615330	+	423	WP_103194965.1	hypothetical protein	-
VVCECT4999_RS08280	1615327..1615449	+	123	WP_088900137.1	DUF3265 domain-containing protein	-
VVCECT4999_RS08290	1615890..1616213	+	324	WP_088900044.1	DUF4144 domain-containing protein	-
VVCECT4999_RS08295	1616248..1616343	+	96	WP_082325131.1	DUF3265 domain-containing protein	-
VVCECT4999_RS08300	1616688..1616810	+	123	WP_088900138.1	DUF3265 domain-containing protein	-
VVCECT4999_RS08305	1616862..1617158	-	297	WP_017420806.1	type II toxin-antitoxin system RelE/ParE family toxin	Toxin
VVCECT4999_RS08310	1617165..1617407	-	243	WP_000557295.1	type II toxin-antitoxin system Phd/YefM family antitoxin	Antitoxin
VVCECT4999_RS08315	1617642..1617977	+	336	WP_039453048.1	hypothetical protein	-
VVCECT4999_RS08320	1617974..1618114	+	141	WP_088900045.1	DUF3265 domain-containing protein	-
VVCECT4999_RS08325	1618457..1618579	+	123	WP_078555065.1	DUF3265 domain-containing protein	-
VVCECT4999_RS08330	1618613..1619188	+	576	WP_039453051.1	hypothetical protein	-
VVCECT4999_RS08335	1619677..1619871	+	195	WP_080729802.1	DUF3265 domain-containing protein	-
VVCECT4999_RS08340	1619828..1620208	+	381	WP_039453052.1	GFA family protein	-
VVCECT4999_RS08345	1620364..1621227	+	864	WP_052171266.1	bacteriophage abortive infection AbiH family protein	-
VVCECT4999_RS08350	1621214..1621357	+	144	WP_080729803.1	DUF3265 domain-containing protein	-
VVCECT4999_RS08360	1621762..1621944	+	183	Protein_1526	DUF3265 domain-containing protein	-
VVCECT4999_RS08365	1621955..1622176	+	222	Protein_1527	transposase	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Genomic island	-	-	1453300..1639357	186057
	-	inside	Integron	-	-	1610307..1629991	19684

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin-antitoxin system, RelE/ParE toxin family (6-93)

Antitoxin

• Type II toxin-antitoxin system, antitoxin Phd/YefM (1-61)

Sequences

Toxin

Protein

• Length: 99 a.a.
• Molecular weight: 11306.95 Da
• Isoelectric Point: 9.6425

>T61577 WP_017420806.1 NZ_CP014636:c1617158-1616862 [Vibrio vulnificus]
MQKNKYKLSKLAQTHLQKIRNYTVNNFSEMQWRSYKDTLLTGFQMLADNPAVGRSCDEIYPSGFYFPVGKHTAYFTKEDG
FILVVAVLGQSQLPQNHL

Nucleotide

• Length: 297 bp

>T61577 NZ_CP014636:c1617158-1616862 [Vibrio vulnificus]
ATGCAAAAGAATAAATATAAGCTAAGTAAATTAGCACAGACTCATTTACAAAAAATCAGAAACTATACCGTCAACAATTT
CTCTGAGATGCAATGGCGAAGCTACAAAGATACCTTACTAACAGGGTTTCAAATGCTTGCTGACAACCCGGCTGTTGGTC
GCAGTTGCGATGAGATATACCCAAGTGGTTTTTATTTCCCTGTAGGCAAGCACACCGCTTACTTTACAAAAGAAGATGGC
TTCATTTTAGTTGTTGCTGTACTCGGTCAATCACAACTTCCGCAGAACCACCTGTAA

Antitoxin

Protein

• Length: 81 a.a.
• Molecular weight: 9002.17 Da
• Isoelectric Point: 4.7914

>AT61577 WP_000557295.1 NZ_CP014636:c1617407-1617165 [Vibrio vulnificus]
MHTLTANDAKRNFGELLLSAQREPVKISKNSKDAVVVMSIKDYEELEAMKTDYLRHCFESAKQDLAQGNVVDGEDFLNAL

Nucleotide

• Length: 243 bp

>AT61577 NZ_CP014636:c1617407-1617165 [Vibrio vulnificus]
ATGCACACATTAACAGCAAATGATGCCAAACGTAATTTTGGTGAGTTACTTCTGAGCGCTCAACGTGAGCCAGTGAAAAT
TAGCAAAAATAGCAAAGATGCCGTAGTTGTTATGTCGATTAAAGACTATGAAGAGCTGGAGGCAATGAAAACTGATTACC
TGAGACATTGTTTCGAGTCAGCTAAGCAAGATTTGGCACAAGGCAATGTAGTTGATGGTGAAGACTTTTTAAACGCCTTA
TAA

Structures

Antitoxin

• AlphaFold DB: A0A151KU25