Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relBE/YafN(antitoxin)
Location 1596357..1596922 Replicon chromosome
Accession NZ_CP014636
Organism Vibrio vulnificus strain CECT 4999

Toxin (Protein)


Gene name relE Uniprot ID A0A7X8U0A9
Locus tag VVCECT4999_RS08120 Protein ID WP_029865673.1
Coordinates 1596635..1596922 (+) Length 96 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID U3BLE1
Locus tag VVCECT4999_RS08115 Protein ID WP_000086647.1
Coordinates 1596357..1596638 (+) Length 94 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
VVCECT4999_RS08075 1591642..1591752 + 111 WP_080553512.1 DUF3265 domain-containing protein -
VVCECT4999_RS08080 1591914..1592942 + 1029 WP_011988369.1 IS630 family transposase -
VVCECT4999_RS08085 1593343..1593738 + 396 WP_052171257.1 hypothetical protein -
VVCECT4999_RS24780 1593753..1593845 + 93 WP_079855370.1 DUF3265 domain-containing protein -
VVCECT4999_RS08100 1594395..1594904 - 510 WP_039452592.1 hypothetical protein -
VVCECT4999_RS08105 1594901..1596064 - 1164 WP_080729763.1 PAAR domain-containing protein -
VVCECT4999_RS08110 1596174..1596266 + 93 WP_193784074.1 DUF3265 domain-containing protein -
VVCECT4999_RS08115 1596357..1596638 + 282 WP_000086647.1 type II toxin-antitoxin system Phd/YefM family antitoxin Antitoxin
VVCECT4999_RS08120 1596635..1596922 + 288 WP_029865673.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
VVCECT4999_RS24625 1596932..1597060 + 129 Protein_1481 DUF3265 domain-containing protein -
VVCECT4999_RS08130 1597404..1597532 + 129 Protein_1482 DUF3265 domain-containing protein -
VVCECT4999_RS08135 1597875..1598003 + 129 WP_081046732.1 DUF3265 domain-containing protein -
VVCECT4999_RS08140 1598352..1598483 + 132 WP_080729818.1 DUF3265 domain-containing protein -
VVCECT4999_RS08145 1598493..1599101 + 609 WP_005377053.1 hypothetical protein -
VVCECT4999_RS08150 1599125..1599214 + 90 WP_072609598.1 DUF3265 domain-containing protein -
VVCECT4999_RS08155 1599248..1599712 + 465 WP_017050696.1 GNAT family N-acetyltransferase -
VVCECT4999_RS08160 1599735..1600691 - 957 WP_039453501.1 IS110 family transposase -
VVCECT4999_RS08170 1601033..1601638 + 606 WP_038964899.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Genomic island - - 1453300..1639357 186057
- flank IS/Tn - - 1599735..1600691 956
- inside Integron - - 1531219..1607550 76331


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(3-88)

Antitoxin

Type II toxin-antitoxin system, antitoxin Phd/YefM

(9-74)


Sequences

Toxin        


Download         Length: 96 a.a.        Molecular weight: 10993.65 Da        Isoelectric Point: 5.1098

>T61576 WP_029865673.1 NZ_CP014636:1596635-1596922 [Vibrio vulnificus]
MKVVWSPLALQKLGDAAEFISLDNPSAAEKWVNEVFDKTELLGSMPEMGRFVPEMPHTNYREIIFGHYRIIYSLSHEIRV
LTVRNCRQILSEDDV

Download         Length: 288 bp

>T61576 NZ_CP014636:1596635-1596922 [Vibrio vulnificus]
ATGAAAGTAGTTTGGTCTCCATTAGCGCTTCAGAAGCTAGGCGATGCAGCGGAGTTTATTTCTTTGGATAATCCATCTGC
GGCAGAAAAGTGGGTAAATGAAGTTTTTGATAAAACCGAACTACTTGGAAGCATGCCTGAAATGGGGCGCTTTGTTCCTG
AAATGCCCCATACGAACTATCGTGAAATCATCTTTGGTCACTATCGGATTATCTACAGCTTAAGTCACGAAATCCGCGTG
CTAACAGTTCGTAATTGTCGTCAAATACTGTCTGAAGATGACGTGTAA

Antitoxin


Download         Length: 94 a.a.        Molecular weight: 10398.91 Da        Isoelectric Point: 5.8650

>AT61576 WP_000086647.1 NZ_CP014636:1596357-1596638 [Vibrio vulnificus]
MSRIHFDQDIQPLSEFRAGVASYIKQINETRRPLVITQRGKGVAVVLDVAEYEAMQEKIELLEEMRTAEAQLASGLGVSN
DDARAQVLGRIKK

Download         Length: 282 bp

>AT61576 NZ_CP014636:1596357-1596638 [Vibrio vulnificus]
ATGAGTCGTATTCATTTCGATCAAGATATTCAGCCGTTATCTGAATTTCGTGCAGGTGTTGCTTCTTACATCAAACAAAT
CAATGAGACTCGCCGTCCATTGGTCATTACACAGCGTGGTAAAGGTGTTGCTGTTGTTCTTGATGTTGCAGAGTATGAAG
CAATGCAAGAGAAAATCGAATTACTAGAAGAAATGCGCACAGCTGAAGCTCAATTAGCTTCAGGCCTTGGTGTTTCCAAT
GATGATGCTCGTGCTCAAGTTCTGGGGCGCATTAAGAAATGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A7X8U0A9

Antitoxin

Source ID Structure
AlphaFold DB A0A4P8G0X0

References