Detailed information of TA system TA061575

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): parDE/ParE-YefM
• Location: 1581356..1581901
• Replicon: chromosome
• Accession: NZ_CP014636
• Organism: Vibrio vulnificus strain CECT 4999

Toxin (Protein)

• Gene name: parE
• Uniprot ID: A0A4U2BEW0
• Locus tag: VVCECT4999_RS07995
• Protein ID: WP_025794194.1
• Coordinates: 1581356..1581652 (-)
• Length: 99 a.a.

Antitoxin (Protein)

• Gene name: parD
• Uniprot ID: -
• Locus tag: VVCECT4999_RS08000
• Protein ID: WP_088900036.1
• Coordinates: 1581659..1581901 (-)
• Length: 81 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
VVCECT4999_RS07960	1576937..1577380	+	444	WP_017420781.1	GNAT family N-acetyltransferase	-
VVCECT4999_RS07965	1577313..1577530	+	218	Protein_1453	DUF3265 domain-containing protein	-
VVCECT4999_RS07970	1577535..1578116	+	582	WP_025796457.1	hypothetical protein	-
VVCECT4999_RS24430	1580234..1580362	+	129	WP_102938348.1	DUF3265 domain-containing protein	-
VVCECT4999_RS07985	1580706..1580834	+	129	Protein_1457	DUF3265 domain-containing protein	-
VVCECT4999_RS07990	1581183..1581305	+	123	Protein_1458	DUF3265 domain-containing protein	-
VVCECT4999_RS07995	1581356..1581652	-	297	WP_025794194.1	type II toxin-antitoxin system RelE/ParE family toxin	Toxin
VVCECT4999_RS08000	1581659..1581901	-	243	WP_088900036.1	type II toxin-antitoxin system Phd/YefM family antitoxin	Antitoxin
VVCECT4999_RS08005	1582989..1583117	+	129	WP_088900133.1	DUF3265 domain-containing protein	-
VVCECT4999_RS08015	1583459..1583587	+	129	WP_080589837.1	DUF3265 domain-containing protein	-
VVCECT4999_RS08025	1583935..1584057	+	123	WP_080584350.1	DUF3265 domain-containing protein	-
VVCECT4999_RS08030	1584116..1584895	-	780	WP_088900037.1	hypothetical protein	-
VVCECT4999_RS08035	1585138..1585569	+	432	WP_046028519.1	NUDIX domain-containing protein	-
VVCECT4999_RS08045	1586044..1586196	+	153	WP_088900038.1	DUF3265 domain-containing protein	-
VVCECT4999_RS08050	1586183..1586713	+	531	WP_086467591.1	hypothetical protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Genomic island	-	-	1453300..1639357	186057
	-	inside	Integron	-	-	1531219..1607550	76331

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin-antitoxin system, RelE/ParE toxin family (6-93)

Antitoxin

• Type II toxin-antitoxin system, antitoxin Phd/YefM (1-63)

Sequences

Toxin

Protein

• Length: 99 a.a.
• Molecular weight: 11234.88 Da
• Isoelectric Point: 9.6269

>T61575 WP_025794194.1 NZ_CP014636:c1581652-1581356 [Vibrio vulnificus]
MQKNKYKLSKLAQAHLRKIKSYTVNNFSEMQWNNYKDTLLTGFQMLADNPAVGRSCDEIYPSGFYFPVGKHTAYFTKEDG
FILVVAVLGQSQLPQNHL

Nucleotide

• Length: 297 bp

>T61575 NZ_CP014636:c1581652-1581356 [Vibrio vulnificus]
ATGCAAAAAAATAAATACAAACTAAGTAAATTGGCTCAGGCTCATTTACGAAAAATTAAAAGCTATACCGTCAACAACTT
TTCTGAAATGCAGTGGAACAACTATAAAGATACATTGCTAACTGGGTTTCAAATGCTTGCCGACAATCCAGCCGTAGGTC
GCAGTTGCGATGAGATTTATCCAAGCGGTTTCTATTTTCCGGTAGGAAAACACACCGCTTACTTTACAAAAGAAGACGGT
TTTATTTTAGTTGTGGCTGTACTTGGTCAATCACAACTCCCACAAAACCACTTGTAG

Antitoxin

Protein

• Length: 81 a.a.
• Molecular weight: 8977.16 Da
• Isoelectric Point: 4.7914

>AT61575 WP_088900036.1 NZ_CP014636:c1581901-1581659 [Vibrio vulnificus]
MHTLTANDAKRNFGELLLSAQREPVKISKNSKDTVVVMSIKDYEELEAMKTDYLKHCFESAKQDLAQGNVVDGEDFLSAL

Nucleotide

• Length: 243 bp

>AT61575 NZ_CP014636:c1581901-1581659 [Vibrio vulnificus]
ATGCACACACTAACAGCAAATGATGCAAAGCGTAACTTTGGTGAGCTGCTTCTAAGCGCCCAACGAGAGCCAGTAAAGAT
TAGCAAAAACAGCAAAGATACCGTAGTGGTAATGTCTATCAAAGACTATGAAGAACTAGAGGCAATGAAAACTGATTACC
TTAAACATTGTTTCGAGTCAGCTAAACAAGACTTAGCACAAGGCAATGTAGTTGATGGTGAAGATTTCCTAAGCGCCTTG
TAA

Structures

Toxin

• AlphaFold DB: A0A4U2BEW0