Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) parDE/ParE-RHH
Location 1507910..1508448 Replicon chromosome
Accession NZ_CP014636
Organism Vibrio vulnificus strain CECT 4999

Toxin (Protein)


Gene name parE Uniprot ID A0A7X8U0Q7
Locus tag VVCECT4999_RS07295 Protein ID WP_019282621.1
Coordinates 1507910..1508209 (-) Length 100 a.a.

Antitoxin (Protein)


Gene name parD Uniprot ID A0A7X8YM83
Locus tag VVCECT4999_RS07300 Protein ID WP_017045414.1
Coordinates 1508206..1508448 (-) Length 81 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
VVCECT4999_RS07235 1503611..1504042 + 432 WP_000074956.1 hypothetical protein -
VVCECT4999_RS07240 1504024..1504182 + 159 WP_080729768.1 DUF3265 domain-containing protein -
VVCECT4999_RS07245 1504179..1504667 + 489 WP_039452584.1 hypothetical protein -
VVCECT4999_RS07250 1504827..1505078 + 252 WP_039452586.1 hypothetical protein -
VVCECT4999_RS07255 1505075..1505272 + 198 WP_039452587.1 hypothetical protein -
VVCECT4999_RS07260 1505300..1505392 + 93 WP_193784109.1 DUF3265 domain-containing protein -
VVCECT4999_RS07275 1506235..1506357 + 123 WP_080729769.1 DUF3265 domain-containing protein -
VVCECT4999_RS07280 1506923..1507318 + 396 WP_052171257.1 hypothetical protein -
VVCECT4999_RS24760 1507333..1507425 + 93 WP_079855370.1 DUF3265 domain-containing protein -
VVCECT4999_RS07290 1507791..1507910 + 120 Protein_1336 DUF3265 domain-containing protein -
VVCECT4999_RS07295 1507910..1508209 - 300 WP_019282621.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
VVCECT4999_RS07300 1508206..1508448 - 243 WP_017045414.1 type II toxin-antitoxin system ParD family antitoxin Antitoxin
VVCECT4999_RS07305 1508532..1508624 + 93 WP_080253812.1 DUF3265 domain-containing protein -
VVCECT4999_RS07310 1508985..1509113 + 129 Protein_1340 DUF3265 domain-containing protein -
VVCECT4999_RS24575 1509507..1509578 + 72 WP_165387259.1 hypothetical protein -
VVCECT4999_RS07325 1509598..1509900 + 303 WP_039452603.1 hypothetical protein -
VVCECT4999_RS07330 1509840..1510007 + 168 WP_001883086.1 DUF3265 domain-containing protein -
VVCECT4999_RS07335 1510133..1510612 + 480 WP_039452607.1 DUF1456 family protein -
VVCECT4999_RS07340 1510627..1510719 + 93 WP_072884142.1 DUF3265 domain-containing protein -
VVCECT4999_RS24765 1510875..1511111 - 237 WP_180982280.1 hypothetical protein -
VVCECT4999_RS07350 1511240..1511329 + 90 WP_080729770.1 DUF3265 domain-containing protein -
VVCECT4999_RS07355 1511395..1511961 - 567 WP_039452612.1 hypothetical protein -
VVCECT4999_RS07360 1512183..1512665 + 483 WP_039452613.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Genomic island - - 1453300..1639357 186057
- inside Integron - - 1452095..1525749 73654


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(6-92)

Antitoxin

Antitoxin ParD

(4-72)


Sequences

Toxin        


Download         Length: 100 a.a.        Molecular weight: 11662.38 Da        Isoelectric Point: 9.8917

>T61571 WP_019282621.1 NZ_CP014636:c1508209-1507910 [Vibrio vulnificus]
MKPFQLTNKAKSDLKDIALFTSRRWGREQRNIYLKQFDESFWLLAENPDIGKTCDEIRDGYRKFPQGSHVIFYQQIGSQN
IQIIRILHKSMDVNPIFGA

Download         Length: 300 bp

>T61571 NZ_CP014636:c1508209-1507910 [Vibrio vulnificus]
ATGAAACCATTCCAACTAACCAACAAGGCAAAATCCGATTTAAAAGATATTGCCTTATTTACCTCTCGCAGGTGGGGCCG
CGAGCAACGAAATATTTATCTCAAACAATTCGATGAATCATTTTGGCTACTCGCTGAAAATCCTGATATCGGTAAAACTT
GTGATGAAATCAGAGATGGCTACCGAAAATTTCCACAAGGAAGCCATGTTATTTTTTATCAACAAATTGGTAGCCAAAAC
ATCCAGATCATAAGAATCTTGCATAAGAGTATGGATGTAAATCCAATCTTTGGCGCATAA

Antitoxin


Download         Length: 81 a.a.        Molecular weight: 8947.89 Da        Isoelectric Point: 4.2213

>AT61571 WP_017045414.1 NZ_CP014636:c1508448-1508206 [Vibrio vulnificus]
MAKNTSITLGDHFDGFISSQIQSGRYGSASEVIRSALRLLETQETKMNTLRQLLVEGEESGMADYDLDSFISELDSEERK

Download         Length: 243 bp

>AT61571 NZ_CP014636:c1508448-1508206 [Vibrio vulnificus]
ATGGCTAAAAATACTAGCATCACTCTCGGCGACCACTTTGATGGTTTCATTAGTAGCCAAATCCAAAGTGGACGCTATGG
CTCAGCAAGTGAAGTAATTCGTTCCGCTCTACGTTTACTCGAAACACAAGAAACGAAAATGAACACTTTACGACAACTGC
TCGTTGAAGGTGAAGAAAGTGGTATGGCTGATTATGACCTCGATTCGTTTATCAGTGAACTAGATAGCGAAGAGAGAAAA
TGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A7X8U0Q7

Antitoxin

Source ID Structure
AlphaFold DB A0A7X8YM83

References