Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relB-yefM/YoeB-RelB
Location 1499806..1500322 Replicon chromosome
Accession NZ_CP014636
Organism Vibrio vulnificus strain CECT 4999

Toxin (Protein)


Gene name relB Uniprot ID A0A6I1QEM1
Locus tag VVCECT4999_RS07185 Protein ID WP_039452891.1
Coordinates 1500053..1500322 (+) Length 90 a.a.

Antitoxin (Protein)


Gene name yefM Uniprot ID U2ZH00
Locus tag VVCECT4999_RS07180 Protein ID WP_005526636.1
Coordinates 1499806..1500060 (+) Length 85 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
VVCECT4999_RS07135 1495240..1495749 + 510 WP_039453389.1 hypothetical protein -
VVCECT4999_RS07140 1495923..1496786 + 864 WP_039452903.1 restriction endonuclease -
VVCECT4999_RS07150 1497452..1497985 + 534 WP_130711842.1 hypothetical protein -
VVCECT4999_RS07155 1497979..1498092 + 114 WP_088900009.1 DUF3265 domain-containing protein -
VVCECT4999_RS07170 1498604..1498948 + 345 WP_017420631.1 hypothetical protein -
VVCECT4999_RS07175 1499114..1499596 + 483 WP_039452894.1 superinfection exclusion B family protein -
VVCECT4999_RS24755 1499614..1499703 + 90 Protein_1318 DUF3265 domain-containing protein -
VVCECT4999_RS07180 1499806..1500060 + 255 WP_005526636.1 type II toxin-antitoxin system prevent-host-death family antitoxin Antitoxin
VVCECT4999_RS07185 1500053..1500322 + 270 WP_039452891.1 Txe/YoeB family addiction module toxin Toxin
VVCECT4999_RS07190 1500557..1500907 + 351 WP_038940876.1 hypothetical protein -
VVCECT4999_RS07195 1500940..1501068 + 129 WP_080532967.1 DUF3265 domain-containing protein -
VVCECT4999_RS07205 1501417..1501536 + 120 Protein_1323 DUF3265 domain-containing protein -
VVCECT4999_RS07210 1501557..1502039 + 483 WP_039452386.1 tetratricopeptide repeat protein -
VVCECT4999_RS07215 1502292..1502552 + 261 WP_038898886.1 hypothetical protein -
VVCECT4999_RS07220 1502596..1502688 + 93 WP_072600976.1 DUF3265 domain-containing protein -
VVCECT4999_RS07235 1503611..1504042 + 432 WP_000074956.1 hypothetical protein -
VVCECT4999_RS07240 1504024..1504182 + 159 WP_080729768.1 DUF3265 domain-containing protein -
VVCECT4999_RS07245 1504179..1504667 + 489 WP_039452584.1 hypothetical protein -
VVCECT4999_RS07250 1504827..1505078 + 252 WP_039452586.1 hypothetical protein -
VVCECT4999_RS07255 1505075..1505272 + 198 WP_039452587.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Genomic island - - 1453300..1639357 186057
- inside Integron - - 1452095..1525749 73654


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin YoeB

(10-89)

Antitoxin

Type II toxin-antitoxin system, antitoxin Phd/YefM

(1-74)


Sequences

Toxin        


Download         Length: 90 a.a.        Molecular weight: 10643.01 Da        Isoelectric Point: 7.9816

>T61570 WP_039452891.1 NZ_CP014636:1500053-1500322 [Vibrio vulnificus]
MSSSQRLLSWTDDAWDDYLYWQTQDKKTLKRINKLINDVKRSPFEGIGKPEPLKENLSGFWSRRIDDTNRLVYAVDDQVI
TIISCRYHY

Download         Length: 270 bp

>T61570 NZ_CP014636:1500053-1500322 [Vibrio vulnificus]
ATGAGTAGTAGTCAACGTTTACTGTCGTGGACTGATGACGCTTGGGATGACTACCTGTATTGGCAAACTCAAGACAAGAA
AACACTCAAGCGCATCAATAAACTCATCAATGATGTTAAGCGCTCCCCATTTGAGGGCATCGGTAAACCAGAGCCGTTAA
AAGAAAACTTGTCTGGTTTTTGGTCTCGTCGTATTGATGACACTAACAGGCTTGTTTATGCAGTTGATGATCAAGTGATA
ACGATAATTTCGTGTCGTTACCACTACTAA

Antitoxin


Download         Length: 85 a.a.        Molecular weight: 9453.60 Da        Isoelectric Point: 5.0623

>AT61570 WP_005526636.1 NZ_CP014636:1499806-1500060 [Vibrio vulnificus]
MRIVSFTEARNGLKAVLDGVVNDADTTVITRRDSEDAVVMSLDYYNSLMETVHLLRSPQNAEHLNRSIAQYRAGKTTARE
LIDE

Download         Length: 255 bp

>AT61570 NZ_CP014636:1499806-1500060 [Vibrio vulnificus]
ATGAGAATTGTATCTTTTACTGAAGCTAGAAATGGTCTCAAGGCTGTTTTGGACGGTGTAGTTAATGACGCCGATACGAC
AGTTATTACCCGCCGTGATTCTGAAGATGCAGTGGTTATGTCGTTAGACTACTACAATAGCCTTATGGAGACAGTTCACT
TACTACGTTCTCCTCAAAATGCCGAACACTTAAACCGTTCGATAGCACAGTACCGTGCTGGTAAAACAACAGCACGAGAG
TTAATTGATGAGTAG

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A6I1QEM1

Antitoxin

Source ID Structure
AlphaFold DB A0A244CM06

References