Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) Txe-Axe/YoeB-RelB
Location 824877..825396 Replicon chromosome
Accession NZ_CP014623
Organism Loigolactobacillus backii strain TMW 1.1988

Toxin (Protein)


Gene name Txe Uniprot ID A0A1Q8FGW1
Locus tag AYR52_RS03765 Protein ID WP_068224043.1
Coordinates 824877..825134 (-) Length 86 a.a.

Antitoxin (Protein)


Gene name Axe Uniprot ID A0A1Q8FGV7
Locus tag AYR52_RS03770 Protein ID WP_068224048.1
Coordinates 825127..825396 (-) Length 90 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
AYR52_RS03745 820165..821058 - 894 WP_082918495.1 LysR family transcriptional regulator -
AYR52_RS03750 821407..822867 + 1461 WP_068224036.1 FAD-dependent oxidoreductase -
AYR52_RS03755 823102..823770 + 669 WP_068224039.1 hypothetical protein -
AYR52_RS03760 823831..824769 + 939 WP_068224042.1 restriction endonuclease -
AYR52_RS03765 824877..825134 - 258 WP_068224043.1 Txe/YoeB family addiction module toxin Toxin
AYR52_RS03770 825127..825396 - 270 WP_068224048.1 type II toxin-antitoxin system Phd/YefM family antitoxin Antitoxin
AYR52_RS03775 825846..827153 + 1308 WP_068224049.1 AAA family ATPase -
AYR52_RS03780 827406..827957 + 552 WP_068224051.1 sugar O-acetyltransferase -
AYR52_RS03785 828428..829606 - 1179 WP_068224053.1 cyclopropane-fatty-acyl-phospholipid synthase family protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin YoeB

(5-85)

Antitoxin

Type II toxin-antitoxin system, antitoxin Phd/YefM

(1-70)


Sequences

Toxin        


Download         Length: 86 a.a.        Molecular weight: 10230.64 Da        Isoelectric Point: 9.4927

>T61566 WP_068224043.1 NZ_CP014623:c825134-824877 [Loigolactobacillus backii]
MVKAWSDGAWNDYLYWHSKNDRAIIKKINRLIKDIERTPYEGLGKPEPLKYELAGKWSRRISDEHRLIYQVANETIYIYS
AKDHY

Download         Length: 258 bp

>T61566 NZ_CP014623:c825134-824877 [Loigolactobacillus backii]
ATGGTTAAAGCCTGGTCAGATGGCGCTTGGAATGATTACCTGTACTGGCACAGTAAAAATGATAGGGCCATCATTAAAAA
AATAAATCGCTTGATTAAGGATATTGAAAGAACACCCTACGAAGGATTGGGGAAACCTGAACCATTGAAATACGAACTGG
CCGGTAAATGGTCGCGGCGAATAAGTGATGAGCACCGCTTAATTTACCAAGTAGCCAACGAAACAATTTACATTTACTCC
GCTAAGGATCACTATTAG

Antitoxin


Download         Length: 90 a.a.        Molecular weight: 10288.49 Da        Isoelectric Point: 4.7833

>AT61566 WP_068224048.1 NZ_CP014623:c825396-825127 [Loigolactobacillus backii]
MDAVAYSNFRQKLKDYMRQVNDDSDALIVTSKNSEENIVVMGKRDYDAMQETMRVLSNNYLMDKIKQGDQQFAKGTFKTH
DLITDENNG

Download         Length: 270 bp

>AT61566 NZ_CP014623:c825396-825127 [Loigolactobacillus backii]
ATGGATGCTGTAGCATACTCTAATTTTCGACAAAAATTAAAAGATTATATGCGCCAGGTTAACGATGATTCGGATGCTTT
AATTGTAACTAGTAAAAATTCGGAAGAAAATATTGTTGTCATGGGTAAACGCGATTACGATGCAATGCAAGAAACGATGC
GCGTTTTATCAAATAATTATCTGATGGATAAAATTAAACAAGGCGATCAGCAATTCGCTAAAGGTACTTTTAAAACCCAT
GACCTAATTACGGATGAAAATAATGGTTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A1Q8FGW1

Antitoxin

Source ID Structure
AlphaFold DB A0A1Q8FGV7

References