Detailed information of TA system
Bioinformatically predictedOverview
TA module
Type | II | Classification (family/domain) | Txe-Axe/YoeB-RelB |
Location | 824877..825396 | Replicon | chromosome |
Accession | NZ_CP014623 | ||
Organism | Loigolactobacillus backii strain TMW 1.1988 |
Toxin (Protein)
Gene name | Txe | Uniprot ID | A0A1Q8FGW1 |
Locus tag | AYR52_RS03765 | Protein ID | WP_068224043.1 |
Coordinates | 824877..825134 (-) | Length | 86 a.a. |
Antitoxin (Protein)
Gene name | Axe | Uniprot ID | A0A1Q8FGV7 |
Locus tag | AYR52_RS03770 | Protein ID | WP_068224048.1 |
Coordinates | 825127..825396 (-) | Length | 90 a.a. |
Genomic Context
Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
---|---|---|---|---|---|---|
AYR52_RS03745 | 820165..821058 | - | 894 | WP_082918495.1 | LysR family transcriptional regulator | - |
AYR52_RS03750 | 821407..822867 | + | 1461 | WP_068224036.1 | FAD-dependent oxidoreductase | - |
AYR52_RS03755 | 823102..823770 | + | 669 | WP_068224039.1 | hypothetical protein | - |
AYR52_RS03760 | 823831..824769 | + | 939 | WP_068224042.1 | restriction endonuclease | - |
AYR52_RS03765 | 824877..825134 | - | 258 | WP_068224043.1 | Txe/YoeB family addiction module toxin | Toxin |
AYR52_RS03770 | 825127..825396 | - | 270 | WP_068224048.1 | type II toxin-antitoxin system Phd/YefM family antitoxin | Antitoxin |
AYR52_RS03775 | 825846..827153 | + | 1308 | WP_068224049.1 | AAA family ATPase | - |
AYR52_RS03780 | 827406..827957 | + | 552 | WP_068224051.1 | sugar O-acetyltransferase | - |
AYR52_RS03785 | 828428..829606 | - | 1179 | WP_068224053.1 | cyclopropane-fatty-acyl-phospholipid synthase family protein | - |
Associated MGEs
MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
---|
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 86 a.a. Molecular weight: 10230.64 Da Isoelectric Point: 9.4927
>T61566 WP_068224043.1 NZ_CP014623:c825134-824877 [Loigolactobacillus backii]
MVKAWSDGAWNDYLYWHSKNDRAIIKKINRLIKDIERTPYEGLGKPEPLKYELAGKWSRRISDEHRLIYQVANETIYIYS
AKDHY
MVKAWSDGAWNDYLYWHSKNDRAIIKKINRLIKDIERTPYEGLGKPEPLKYELAGKWSRRISDEHRLIYQVANETIYIYS
AKDHY
Download Length: 258 bp
>T61566 NZ_CP014623:c825134-824877 [Loigolactobacillus backii]
ATGGTTAAAGCCTGGTCAGATGGCGCTTGGAATGATTACCTGTACTGGCACAGTAAAAATGATAGGGCCATCATTAAAAA
AATAAATCGCTTGATTAAGGATATTGAAAGAACACCCTACGAAGGATTGGGGAAACCTGAACCATTGAAATACGAACTGG
CCGGTAAATGGTCGCGGCGAATAAGTGATGAGCACCGCTTAATTTACCAAGTAGCCAACGAAACAATTTACATTTACTCC
GCTAAGGATCACTATTAG
ATGGTTAAAGCCTGGTCAGATGGCGCTTGGAATGATTACCTGTACTGGCACAGTAAAAATGATAGGGCCATCATTAAAAA
AATAAATCGCTTGATTAAGGATATTGAAAGAACACCCTACGAAGGATTGGGGAAACCTGAACCATTGAAATACGAACTGG
CCGGTAAATGGTCGCGGCGAATAAGTGATGAGCACCGCTTAATTTACCAAGTAGCCAACGAAACAATTTACATTTACTCC
GCTAAGGATCACTATTAG
Antitoxin
Download Length: 90 a.a. Molecular weight: 10288.49 Da Isoelectric Point: 4.7833
>AT61566 WP_068224048.1 NZ_CP014623:c825396-825127 [Loigolactobacillus backii]
MDAVAYSNFRQKLKDYMRQVNDDSDALIVTSKNSEENIVVMGKRDYDAMQETMRVLSNNYLMDKIKQGDQQFAKGTFKTH
DLITDENNG
MDAVAYSNFRQKLKDYMRQVNDDSDALIVTSKNSEENIVVMGKRDYDAMQETMRVLSNNYLMDKIKQGDQQFAKGTFKTH
DLITDENNG
Download Length: 270 bp
>AT61566 NZ_CP014623:c825396-825127 [Loigolactobacillus backii]
ATGGATGCTGTAGCATACTCTAATTTTCGACAAAAATTAAAAGATTATATGCGCCAGGTTAACGATGATTCGGATGCTTT
AATTGTAACTAGTAAAAATTCGGAAGAAAATATTGTTGTCATGGGTAAACGCGATTACGATGCAATGCAAGAAACGATGC
GCGTTTTATCAAATAATTATCTGATGGATAAAATTAAACAAGGCGATCAGCAATTCGCTAAAGGTACTTTTAAAACCCAT
GACCTAATTACGGATGAAAATAATGGTTAA
ATGGATGCTGTAGCATACTCTAATTTTCGACAAAAATTAAAAGATTATATGCGCCAGGTTAACGATGATTCGGATGCTTT
AATTGTAACTAGTAAAAATTCGGAAGAAAATATTGTTGTCATGGGTAAACGCGATTACGATGCAATGCAAGAAACGATGC
GCGTTTTATCAAATAATTATCTGATGGATAAAATTAAACAAGGCGATCAGCAATTCGCTAAAGGTACTTTTAAAACCCAT
GACCTAATTACGGATGAAAATAATGGTTAA
Similar Proteins
Only experimentally validated proteins are listed.
Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
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Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
---|
Structures
Toxin
Source | ID | Structure |
---|---|---|
AlphaFold DB | A0A1Q8FGW1 |
Antitoxin
Source | ID | Structure |
---|---|---|
AlphaFold DB | A0A1Q8FGV7 |