Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) /RES-TIGR02293
Location 4847252..4848153 Replicon chromosome
Accession NZ_CP014608
Organism Obesumbacterium proteus strain DSM 2777

Toxin (Protein)


Gene name - Uniprot ID A0A806Z3T9
Locus tag DSM2777_RS22660 Protein ID WP_061555212.1
Coordinates 4847252..4847710 (-) Length 153 a.a.

Antitoxin (Protein)


Gene name - Uniprot ID A0A806Z7C7
Locus tag DSM2777_RS22665 Protein ID WP_046459353.1
Coordinates 4847707..4848153 (-) Length 149 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
DSM2777_RS22640 4842810..4843370 - 561 WP_061555209.1 hypothetical protein -
DSM2777_RS22645 4843656..4844147 + 492 WP_082790934.1 hypothetical protein -
DSM2777_RS22650 4844501..4846639 + 2139 WP_046459356.1 anaerobic ribonucleoside-triphosphate reductase -
DSM2777_RS22655 4846782..4847246 + 465 WP_061555211.1 anaerobic ribonucleoside-triphosphate reductase-activating protein -
DSM2777_RS22660 4847252..4847710 - 459 WP_061555212.1 RES family NAD+ phosphorylase Toxin
DSM2777_RS22665 4847707..4848153 - 447 WP_046459353.1 DUF2384 domain-containing protein Antitoxin
DSM2777_RS22670 4848513..4849313 + 801 WP_061555213.1 phosphonate ABC transporter ATP-binding protein -
DSM2777_RS22675 4849349..4850365 + 1017 WP_061555214.1 phosphonate ABC transporter substrate-binding protein -
DSM2777_RS22680 4850441..4851235 + 795 WP_025798923.1 phosphonate ABC transporter, permease protein PhnE -
DSM2777_RS22685 4851256..4851981 + 726 WP_061555215.1 phosphonate metabolism transcriptional regulator PhnF -
DSM2777_RS22690 4851982..4852455 + 474 WP_046459350.1 phosphonate C-P lyase system protein PhnG -
DSM2777_RS22695 4852455..4853054 + 600 WP_061555467.1 phosphonate C-P lyase system protein PhnH -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

RES domain

(4-143)

Antitoxin

Antitoxin Xre/MbcA/ParS-like, toxin-binding domain

(94-145)


Sequences

Toxin        


Download         Length: 153 a.a.        Molecular weight: 17067.59 Da        Isoelectric Point: 6.7199

>T61559 WP_061555212.1 NZ_CP014608:c4847710-4847252 [Obesumbacterium proteus]
MMGYRIVKTKFANSAFTGQGAKQFGGRWNRMGSPMVYLASSISLAMLECLVHLESARLTEFYSLFSIEIDDRDISSLDVS
VLPAQWRQDEISSVTADMGSQWIASKVSVGLRVPSVIVPQENNLLLNPQHPKFERYLTTVAEVPHAFDERLK

Download         Length: 459 bp

>T61559 NZ_CP014608:c4847710-4847252 [Obesumbacterium proteus]
ATGATGGGCTATCGCATTGTTAAAACCAAATTTGCAAACAGCGCATTCACGGGGCAGGGAGCAAAACAGTTTGGCGGGCG
TTGGAACCGCATGGGTAGCCCAATGGTGTATCTGGCCAGTTCTATCTCGCTTGCGATGCTGGAATGTTTGGTTCACCTCG
AAAGCGCACGGCTAACTGAGTTTTACTCGCTTTTTTCGATAGAAATTGACGACCGTGATATTAGCTCGCTAGATGTCAGC
GTATTGCCTGCTCAATGGCGTCAGGATGAAATCTCATCGGTAACTGCCGATATGGGGTCACAGTGGATAGCATCGAAGGT
ATCCGTAGGATTACGGGTGCCTTCGGTGATTGTGCCACAGGAAAATAATCTTTTACTGAATCCGCAGCATCCAAAATTTG
AACGCTATCTAACCACGGTGGCTGAAGTGCCGCATGCTTTTGATGAACGACTGAAATGA

Antitoxin


Download         Length: 149 a.a.        Molecular weight: 16294.67 Da        Isoelectric Point: 6.9911

>AT61559 WP_046459353.1 NZ_CP014608:c4848153-4847707 [Obesumbacterium proteus]
MRMFTPAQQRDESTLWHVVSFPPEGSIQLLELLKQGLPTDVIENIHQWTGINKADIVQIAGISGRQVSRRKNGPKTLSPE
QSESIARLVRVMNAAIALFEDDKEQAIHWLTHPVRALGQTAPASLISTESGAIAVLNLIGRLEHGVFS

Download         Length: 447 bp

>AT61559 NZ_CP014608:c4848153-4847707 [Obesumbacterium proteus]
ATGCGTATGTTCACACCCGCTCAGCAGCGAGATGAAAGCACACTTTGGCACGTAGTGAGTTTTCCGCCAGAAGGTAGCAT
TCAGCTGCTTGAGTTGCTTAAACAGGGATTACCCACCGACGTGATTGAAAATATTCACCAATGGACGGGGATTAATAAGG
CCGATATCGTCCAAATCGCGGGGATCAGCGGTCGTCAGGTTTCTCGTAGAAAGAATGGGCCTAAAACGTTATCGCCTGAG
CAGAGTGAAAGTATTGCTCGTTTGGTGAGGGTGATGAACGCGGCGATTGCCCTTTTTGAGGATGATAAAGAGCAGGCTAT
CCACTGGCTAACACATCCTGTGCGTGCACTGGGACAGACTGCTCCAGCGAGTCTCATCAGCACGGAGAGTGGAGCCATTG
CGGTATTGAACCTGATCGGGCGCTTGGAGCACGGTGTATTCTCATGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A806Z3T9

Antitoxin

Source ID Structure
AlphaFold DB A0A806Z7C7

References