Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) Hha-TomB/-
Location 4189459..4190050 Replicon chromosome
Accession NZ_CP014608
Organism Obesumbacterium proteus strain DSM 2777

Toxin (Protein)


Gene name Hha Uniprot ID G9Y5B5
Locus tag DSM2777_RS19515 Protein ID WP_004091739.1
Coordinates 4189847..4190050 (+) Length 68 a.a.

Antitoxin (Protein)


Gene name TomB Uniprot ID A0A0M2NDT8
Locus tag DSM2777_RS19510 Protein ID WP_046457234.1
Coordinates 4189459..4189827 (+) Length 123 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
DSM2777_RS19490 4184579..4185031 + 453 WP_025799896.1 NfeD family protein -
DSM2777_RS19495 4185076..4185483 - 408 WP_046457231.1 Cu(I)-responsive transcriptional regulator -
DSM2777_RS19500 4185606..4188365 + 2760 WP_061554926.1 copper-exporting P-type ATPase CopA -
DSM2777_RS19505 4188534..4188806 + 273 WP_061554927.1 type B 50S ribosomal protein L31 -
DSM2777_RS23925 4188806..4188946 + 141 WP_004091741.1 type B 50S ribosomal protein L36 -
DSM2777_RS19510 4189459..4189827 + 369 WP_046457234.1 Hha toxicity modulator TomB Antitoxin
DSM2777_RS19515 4189847..4190050 + 204 WP_004091739.1 hemolysin expression modulator Hha Toxin
DSM2777_RS19520 4190249..4190668 - 420 WP_061554928.1 DUF1311 domain-containing protein -
DSM2777_RS19530 4191162..4191500 + 339 WP_061554929.1 MGMT family protein -
DSM2777_RS19535 4191548..4192066 - 519 WP_046457237.1 YbaY family lipoprotein -
DSM2777_RS19540 4192359..4193219 + 861 WP_046457238.1 acyl-CoA thioesterase II -
DSM2777_RS19545 4193300..4194592 - 1293 WP_174521859.1 ammonium transporter AmtB -
DSM2777_RS19550 4194623..4194961 - 339 WP_004091732.1 P-II family nitrogen regulator -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Haemolysin expression modulating, HHA

(8-64)

Antitoxin

Biofilm formation regulator YbaJ

(1-114)


Sequences

Toxin        


Download         Length: 68 a.a.        Molecular weight: 8119.38 Da        Isoelectric Point: 5.8346

>T61557 WP_004091739.1 NZ_CP014608:4189847-4190050 [Obesumbacterium proteus]
MTKIDYLMRLRKCTTLDTLERVIEKNKYELSDDELETFYSAADHRLAELTMNKLYDKIPAEVWKYVR

Download         Length: 204 bp

>T61557 NZ_CP014608:4189847-4190050 [Obesumbacterium proteus]
ATGACTAAAATTGATTACCTTATGCGCTTACGCAAGTGTACAACGCTAGACACTTTAGAGCGCGTAATTGAAAAAAACAA
ATACGAGCTCTCCGACGATGAGCTAGAAACTTTCTACTCAGCCGCCGACCATCGTTTGGCCGAACTCACCATGAACAAAC
TGTACGATAAGATCCCTGCTGAAGTTTGGAAGTATGTACGTTAA

Antitoxin


Download         Length: 123 a.a.        Molecular weight: 14172.98 Da        Isoelectric Point: 4.7386

>AT61557 WP_046457234.1 NZ_CP014608:4189459-4189827 [Obesumbacterium proteus]
MDEYTSYQHDITELKYLCNMLYNQGMEVLSDSHHGWVNDPTAVANLQLNELNEHIATFGLTFKIKYPKSSELTEILDEYL
DETYSLFSNYSINEPELKKWLKAKGRILRYLAGEKPASALNF

Download         Length: 369 bp

>AT61557 NZ_CP014608:4189459-4189827 [Obesumbacterium proteus]
ATGGATGAATACACGTCTTATCAGCACGATATAACTGAACTGAAATACCTGTGTAATATGCTGTATAATCAGGGAATGGA
AGTTCTGAGTGATAGCCATCATGGCTGGGTTAATGACCCAACTGCTGTAGCTAACCTGCAACTCAATGAATTAAACGAAC
ATATCGCAACGTTCGGTTTAACGTTCAAGATTAAGTATCCAAAGAGTTCAGAATTAACTGAAATATTAGATGAGTATCTT
GACGAAACTTACAGTCTGTTTAGTAATTACAGCATAAACGAACCAGAACTAAAAAAATGGCTTAAAGCAAAAGGCCGTAT
TTTGCGTTATTTAGCGGGTGAAAAACCAGCATCCGCGTTGAATTTTTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB G9Y5B5

Antitoxin

Source ID Structure
AlphaFold DB A0A0M2NDT8

References