Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relBE/RelE(toxin)
Location 961713..962179 Replicon chromosome
Accession NZ_CP014608
Organism Obesumbacterium proteus strain DSM 2777

Toxin (Protein)


Gene name relE Uniprot ID A0A806Z0N7
Locus tag DSM2777_RS04600 Protein ID WP_061553289.1
Coordinates 961713..961988 (-) Length 92 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID A0A806YV42
Locus tag DSM2777_RS04605 Protein ID WP_061553290.1
Coordinates 961988..962179 (-) Length 64 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
DSM2777_RS04580 957996..958922 + 927 WP_061553288.1 high-affinity branched-chain amino acid ABC transporter permease LivH -
DSM2777_RS04585 958919..960190 + 1272 WP_046459441.1 high-affinity branched-chain amino acid ABC transporter permease LivM -
DSM2777_RS04590 960187..960957 + 771 WP_025799388.1 high-affinity branched-chain amino acid ABC transporter ATP-binding protein LivG -
DSM2777_RS04595 960960..961661 + 702 WP_040046465.1 high-affinity branched-chain amino acid ABC transporter ATP-binding protein LivF -
DSM2777_RS04600 961713..961988 - 276 WP_061553289.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
DSM2777_RS04605 961988..962179 - 192 WP_061553290.1 hypothetical protein Antitoxin
DSM2777_RS04610 962523..963845 + 1323 WP_061553291.1 sn-glycerol-3-phosphate ABC transporter substrate-binding protein UgpB -
DSM2777_RS04615 963926..964813 + 888 WP_061553292.1 sn-glycerol-3-phosphate ABC transporter permease UgpA -
DSM2777_RS04620 964810..965655 + 846 WP_025799379.1 sn-glycerol-3-phosphate ABC transporter permease UgpE -
DSM2777_RS04625 965660..966736 + 1077 WP_061553293.1 sn-glycerol-3-phosphate import ATP-binding protein UgpC -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(4-90)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 92 a.a.        Molecular weight: 10395.92 Da        Isoelectric Point: 4.7236

>T61546 WP_061553289.1 NZ_CP014608:c961988-961713 [Obesumbacterium proteus]
MLTVKWTDDAIHDLYTLIAFVAEQNPFAAEALMQRIDEAILPAAEHPYLFRSGRVLGTREIVAHPNYIVVYQITIDSIEV
LSVLHSRQEYP

Download         Length: 276 bp

>T61546 NZ_CP014608:c961988-961713 [Obesumbacterium proteus]
ATGCTAACCGTCAAATGGACTGACGATGCCATACACGATTTATATACCCTGATAGCTTTCGTTGCCGAGCAAAATCCTTT
TGCTGCTGAAGCTTTAATGCAACGCATTGATGAAGCGATATTACCTGCTGCCGAACATCCTTATTTGTTCCGATCTGGCC
GAGTATTAGGAACCAGAGAGATCGTTGCACATCCCAACTATATTGTGGTTTATCAGATAACCATCGACAGCATTGAAGTG
CTATCTGTTCTTCATTCCCGACAAGAATATCCTTAA

Antitoxin


Download         Length: 64 a.a.        Molecular weight: 7215.25 Da        Isoelectric Point: 9.7687

>AT61546 WP_061553290.1 NZ_CP014608:c962179-961988 [Obesumbacterium proteus]
MQKKLSPIVSEFETQEQADSYEHWFKAKVEASMDNNRARVPHDEVMAGARKIIAEAKAKRKLA

Download         Length: 192 bp

>AT61546 NZ_CP014608:c962179-961988 [Obesumbacterium proteus]
ATGCAGAAAAAACTCTCCCCTATCGTTTCAGAGTTTGAAACTCAGGAACAAGCAGATAGCTATGAGCATTGGTTTAAAGC
GAAAGTAGAAGCATCAATGGATAATAATCGTGCCAGAGTACCTCATGACGAAGTCATGGCGGGCGCACGTAAAATTATTG
CTGAAGCCAAAGCTAAAAGGAAATTAGCCTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A806Z0N7

Antitoxin

Source ID Structure
AlphaFold DB A0A806YV42

References