Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) tacAT/DUF1778(antitoxin)
Location 22916..23694 Replicon chromosome
Accession NZ_CP014608
Organism Obesumbacterium proteus strain DSM 2777

Toxin (Protein)


Gene name TacT2 Uniprot ID A0A806YTE4
Locus tag DSM2777_RS00125 Protein ID WP_061552808.1
Coordinates 22916..23404 (-) Length 163 a.a.

Antitoxin (Protein)


Gene name TacA2 Uniprot ID A0A806YZP9
Locus tag DSM2777_RS00130 Protein ID WP_046458255.1
Coordinates 23401..23694 (-) Length 98 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
DSM2777_RS23530 21841..22092 + 252 WP_071889838.1 hypothetical protein -
DSM2777_RS00120 22257..22709 + 453 WP_061552807.1 hypothetical protein -
DSM2777_RS00125 22916..23404 - 489 WP_061552808.1 GNAT family N-acetyltransferase Toxin
DSM2777_RS00130 23401..23694 - 294 WP_046458255.1 DUF1778 domain-containing protein Antitoxin
DSM2777_RS00135 23849..24730 - 882 WP_156088306.1 LysR family transcriptional regulator -
DSM2777_RS00140 24834..25337 + 504 WP_061552810.1 phenolic acid decarboxylase -
DSM2777_RS00145 25400..26818 - 1419 WP_061552811.1 aldehyde dehydrogenase family protein -
DSM2777_RS00150 26941..27849 + 909 WP_061552812.1 LysR family transcriptional regulator -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

GNAT domain

(27-145)

Antitoxin

Vibrio phage ICP1, Orf50

(3-95)


Sequences

Toxin        


Download         Length: 163 a.a.        Molecular weight: 17746.66 Da        Isoelectric Point: 7.7302

>T61545 WP_061552808.1 NZ_CP014608:c23404-22916 [Obesumbacterium proteus]
MISAPEPLHARLDVNAFCCGVDSMDNWLRQRAMKNQITGASRTFVCCDDNARVVAYYSLASSAVMSNSAPGRFRRNMPDP
IPVMVLGRLAVDKSLHGQGVGRALVRDAGLRVIQVAETIGIRGMLVHALSDEAREFYLRVGFEPSPMDPMMLMVTLGDLL
HA

Download         Length: 489 bp

>T61545 NZ_CP014608:c23404-22916 [Obesumbacterium proteus]
ATGATCTCCGCTCCTGAACCGCTTCACGCCAGACTCGATGTTAATGCATTTTGCTGTGGCGTGGATTCTATGGATAACTG
GCTCAGGCAGCGGGCGATGAAAAATCAAATTACCGGAGCATCTCGTACCTTTGTGTGCTGCGATGATAATGCCAGAGTTG
TGGCGTATTACTCATTAGCGTCCAGCGCGGTGATGAGCAACTCTGCCCCCGGCCGTTTTCGCCGTAACATGCCCGACCCG
ATCCCTGTCATGGTGTTAGGACGATTGGCGGTAGATAAATCACTGCATGGTCAGGGCGTAGGCCGCGCGTTGGTGCGTGA
TGCGGGGTTGCGGGTGATTCAGGTCGCGGAAACTATAGGAATCCGTGGCATGTTGGTTCACGCATTATCTGATGAAGCGC
GGGAATTTTATCTACGAGTGGGATTTGAGCCATCGCCAATGGACCCGATGATGCTGATGGTGACGCTGGGAGATTTGCTT
CATGCCTGA

Antitoxin


Download         Length: 98 a.a.        Molecular weight: 10975.73 Da        Isoelectric Point: 10.1968

>AT61545 WP_046458255.1 NZ_CP014608:c23694-23401 [Obesumbacterium proteus]
MPMTNSMPIKRETLNLRIKPAERDLIDRAAKARGKNRTDFVLEAARAAAEEALIEQRIIMADPDAYQAFLTRLDEAPAPN
AALRKTMQTLAPWEQKK

Download         Length: 294 bp

>AT61545 NZ_CP014608:c23694-23401 [Obesumbacterium proteus]
ATGCCAATGACAAATAGCATGCCCATTAAACGCGAAACATTGAATCTTCGCATTAAACCCGCTGAACGCGATCTTATCGA
TCGGGCGGCGAAAGCCAGAGGAAAAAATCGTACTGATTTTGTTCTGGAAGCTGCACGTGCGGCGGCTGAGGAAGCGTTGA
TTGAACAGCGTATTATCATGGCCGATCCTGATGCTTATCAGGCGTTCCTTACTCGTCTGGATGAAGCACCTGCGCCAAAC
GCCGCGCTGCGTAAAACAATGCAAACACTCGCTCCGTGGGAGCAGAAAAAATGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A806YTE4

Antitoxin

Source ID Structure
AlphaFold DB A0A806YZP9

References