Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/PIN-doc
Location 189442..190072 Replicon plasmid unnamed2
Accession NZ_CP014598
Organism Yangia sp. CCB-MM3

Toxin (Protein)


Gene name vapC Uniprot ID A0A1B1PXI0
Locus tag AYJ57_RS22705 Protein ID WP_066111352.1
Coordinates 189671..190072 (+) Length 134 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID A0A1B1PXR0
Locus tag AYJ57_RS22700 Protein ID WP_066111502.1
Coordinates 189442..189669 (+) Length 76 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
AYJ57_RS22690 185174..186298 + 1125 WP_066111349.1 flagellar biosynthesis protein FlhB -
AYJ57_RS22695 186501..188705 + 2205 WP_066111350.1 NADP-dependent isocitrate dehydrogenase -
AYJ57_RS22700 189442..189669 + 228 WP_066111502.1 AbrB/MazE/SpoVT family DNA-binding domain-containing protein Antitoxin
AYJ57_RS22705 189671..190072 + 402 WP_066111352.1 PIN domain-containing protein Toxin
AYJ57_RS22710 190180..191139 + 960 WP_066111354.1 cytochrome c oxidase subunit II -
AYJ57_RS22715 191147..193702 + 2556 WP_066111356.1 cytochrome c oxidase subunit I -
AYJ57_RS22720 193702..194139 + 438 WP_066111357.1 hypothetical protein -
AYJ57_RS22725 194133..194711 + 579 WP_066111359.1 cytochrome c oxidase assembly protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Non-Mobilizable plasmid - - 1..274486 274486


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(5-113)

Antitoxin

SpoVT-AbrB domain

(5-37)


Sequences

Toxin        


Download         Length: 134 a.a.        Molecular weight: 14496.57 Da        Isoelectric Point: 4.9347

>T61543 WP_066111352.1 NZ_CP014598:189671-190072 [Yangia sp. CCB-MM3]
MAQSFFDTNVILYLLGEGPKADRAETLLAQGGVISVQVLNEALVNCRRKAKMSHEEAGEFLGAIRALCETRPLTEGTHDI
GRALGTRYGFSVYDSMIVAAALEAGCETLWSEDMHDGLLVEGRLRIVNPFRPG

Download         Length: 402 bp

>T61543 NZ_CP014598:189671-190072 [Yangia sp. CCB-MM3]
ATGGCGCAGAGCTTTTTCGACACCAATGTGATCCTCTACCTGCTGGGCGAGGGGCCGAAGGCGGATCGCGCCGAGACGCT
GCTTGCTCAGGGCGGGGTGATCAGCGTGCAGGTGCTGAACGAGGCGCTGGTCAATTGCCGCCGGAAGGCCAAGATGAGCC
ATGAGGAGGCCGGGGAGTTCCTCGGCGCGATCCGAGCGCTCTGCGAGACCCGCCCATTGACCGAAGGCACCCATGACATC
GGTCGCGCGCTTGGCACGCGCTACGGGTTCTCGGTCTACGATTCCATGATCGTGGCGGCGGCGCTCGAGGCGGGCTGCGA
GACGCTGTGGTCAGAGGACATGCACGATGGGCTGCTGGTCGAAGGGCGCCTGCGCATCGTCAATCCCTTTCGTCCCGGCT
AA

Antitoxin


Download         Length: 76 a.a.        Molecular weight: 8442.62 Da        Isoelectric Point: 11.1777

>AT61543 WP_066111502.1 NZ_CP014598:189442-189669 [Yangia sp. CCB-MM3]
MQVSKWGNSLAVRLPADLVRELGLKEGDRIDLHPDARGLAVSRAERPEEILQGLRRFRGRLPDAARLSRDEANAR

Download         Length: 228 bp

>AT61543 NZ_CP014598:189442-189669 [Yangia sp. CCB-MM3]
ATGCAAGTTTCGAAATGGGGCAACTCCCTCGCCGTGCGCCTGCCTGCTGATCTCGTACGCGAGCTTGGCTTGAAAGAGGG
TGACCGGATCGACCTGCACCCCGATGCGCGCGGCCTTGCGGTGAGCCGGGCGGAACGGCCCGAGGAGATCCTCCAAGGCC
TCCGCCGGTTCCGCGGGCGATTGCCCGATGCCGCCCGGCTGAGCCGCGACGAGGCCAACGCGCGCTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A1B1PXI0

Antitoxin

Source ID Structure
AlphaFold DB A0A1B1PXR0

References