Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) phd-doc/HTH_IclR(antitoxin)
Location 3380897..3382690 Replicon chromosome
Accession NZ_CP014579
Organism Paraburkholderia phytofirmans OLGA172

Toxin (Protein)


Gene name doc Uniprot ID A0A160FVE6
Locus tag AYM40_RS35010 Protein ID WP_063500489.1
Coordinates 3381800..3382690 (-) Length 297 a.a.

Antitoxin (Protein)


Gene name phd Uniprot ID -
Locus tag AYM40_RS35005 Protein ID WP_162493834.1
Coordinates 3380897..3381799 (-) Length 301 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
AYM40_RS34985 3376098..3377588 - 1491 WP_063500485.1 aldehyde dehydrogenase -
AYM40_RS34990 3377629..3378459 - 831 WP_063500486.1 aspartate dehydrogenase -
AYM40_RS34995 3378452..3380110 - 1659 WP_063500487.1 thiamine pyrophosphate-binding protein -
AYM40_RS35000 3380103..3380900 - 798 WP_063500488.1 SDR family oxidoreductase -
AYM40_RS35005 3380897..3381799 - 903 WP_162493834.1 IclR family transcriptional regulator Antitoxin
AYM40_RS35010 3381800..3382690 - 891 WP_063500489.1 alpha/beta hydrolase Toxin
AYM40_RS35015 3382730..3383257 - 528 WP_063500490.1 cupin domain-containing protein -
AYM40_RS35020 3383284..3384060 - 777 WP_063500491.1 SDR family oxidoreductase -
AYM40_RS35025 3384053..3385150 - 1098 WP_063500492.1 aromatic ring-hydroxylating dioxygenase subunit alpha -
AYM40_RS35030 3385200..3385511 - 312 WP_063500493.1 hypothetical protein -
AYM40_RS35035 3385513..3385827 - 315 WP_020068683.1 non-heme iron oxygenase ferredoxin subunit -
AYM40_RS35040 3386268..3387344 + 1077 WP_063500494.1 porin -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Alpha/beta hydrolase fold-1

(50-279)

Antitoxin

Transcription regulator IclR, C-terminal

(153-277)


Sequences

Toxin        


Download         Length: 297 a.a.        Molecular weight: 31329.33 Da        Isoelectric Point: 5.9472

>T61516 WP_063500489.1 NZ_CP014579:c3382690-3381800 [Paraburkholderia phytofirmans OLGA172]
MSAVPSATVDQNATLEACLARFPAQQIRLASQRAVSYRDVDSAASEALPLVLLHGIGSGAASWVQQFEVLGETRRVLAWD
APGYGASTPVEADSPAASDYATVLKDWLDALGIERCVLLGHSLGAIMAGAFAVTNPQRVDGLLLLSPARGYGASSAEVRE
TKRDQRLAMINELGPQGLAEQRSANMLSAHASDEARAWVRWNMSRVIPHGYAQATHLLANADLASDLARYRGRINIAAGA
DDAITPPEACERLALAAGTKLQVVPRAGHAGYIEAPAAYTAIIDTFCRASDGQRSQ

Download         Length: 891 bp

>T61516 NZ_CP014579:c3382690-3381800 [Paraburkholderia phytofirmans OLGA172]
ATGTCCGCAGTCCCGTCCGCTACCGTCGATCAGAACGCTACGCTCGAAGCATGCCTTGCACGCTTTCCCGCGCAGCAAAT
CCGGCTGGCATCGCAACGTGCGGTGAGCTATCGCGATGTGGATAGCGCCGCAAGCGAAGCACTGCCTTTGGTGCTGCTTC
ACGGTATCGGCTCGGGCGCGGCTTCCTGGGTTCAGCAGTTTGAAGTGCTGGGTGAGACGCGTCGTGTGCTGGCATGGGAT
GCGCCAGGGTATGGCGCATCAACACCTGTAGAAGCCGATTCGCCCGCTGCAAGCGATTACGCAACTGTACTAAAGGATTG
GCTCGACGCGCTTGGCATTGAACGCTGCGTGCTGCTGGGGCATTCGCTTGGCGCGATCATGGCTGGTGCGTTTGCCGTGA
CGAATCCGCAGCGTGTGGACGGCTTGCTGCTGTTGTCGCCGGCTCGCGGTTATGGCGCTTCGTCGGCGGAAGTGCGCGAG
ACGAAACGCGATCAGCGTCTCGCCATGATTAACGAACTCGGCCCGCAAGGTCTCGCCGAACAACGCAGCGCCAACATGTT
GTCCGCGCATGCGAGCGACGAAGCGCGCGCATGGGTGCGCTGGAACATGTCGCGCGTGATTCCGCACGGTTATGCGCAGG
CAACGCATCTGCTAGCCAATGCCGATCTCGCCAGCGATCTTGCGCGCTACCGAGGCCGCATCAACATCGCGGCCGGTGCA
GACGACGCCATTACGCCCCCCGAAGCCTGCGAGCGACTCGCTCTCGCCGCCGGCACCAAACTGCAGGTCGTGCCACGCGC
GGGGCATGCAGGTTACATCGAAGCACCCGCCGCGTACACCGCGATCATCGACACGTTCTGCCGCGCGAGCGACGGACAAC
GGAGCCAATGA

Antitoxin


Download         Length: 301 a.a.        Molecular weight: 33340.89 Da        Isoelectric Point: 6.7732

>AT61516 WP_162493834.1 NZ_CP014579:c3381799-3380897 [Paraburkholderia phytofirmans OLGA172]
MTSDTHDMVSAERDADDDRNDADTSSEISYRVPGLERGLKILTEFSPREPVLGAPELSKRLKIPRTTVFRLLQTLESLGF
LERADKDRNYRLGVAVLRLGFEYLSSLELTDLGLPIIEALRNDTGLTSHIVIRDGRDVVFVAKAQSHAPIFSSVKVNVGT
RLPAHATTHGQVLMGDMTLDDLKKLYPEPELERFTKQTPATIDDLYERVRDDARRGFAISESSFERGISVVSAPVRNDAG
RIVAVITTTIPRHEIDASLLDSGLIEKVRRAADELSQRLNYRPKGSPNAGTKYMKALGLK

Download         Length: 903 bp

>AT61516 NZ_CP014579:c3381799-3380897 [Paraburkholderia phytofirmans OLGA172]
ATGACGTCCGACACGCATGACATGGTTAGCGCCGAGCGCGACGCGGACGACGACCGCAACGACGCAGACACCAGCAGCGA
GATCAGCTATCGCGTGCCGGGTCTGGAGCGCGGTCTGAAGATTCTGACGGAGTTCTCGCCGCGCGAGCCGGTTCTCGGCG
CACCGGAATTATCGAAGCGCCTGAAGATTCCCCGCACGACGGTGTTCCGTCTGCTGCAAACGCTCGAATCGCTCGGTTTT
CTCGAGCGCGCCGACAAGGACCGCAACTATCGCCTCGGCGTCGCGGTGCTGCGGCTCGGTTTCGAATATCTGAGCTCGCT
CGAATTGACCGACCTCGGTTTGCCGATCATCGAAGCGCTGCGTAACGACACGGGCCTCACCAGCCACATCGTGATTCGCG
ACGGACGCGATGTCGTGTTCGTCGCCAAAGCGCAAAGCCATGCGCCGATCTTCAGCTCGGTGAAGGTGAATGTCGGCACG
CGCCTGCCGGCTCACGCGACGACGCACGGCCAGGTGCTGATGGGCGACATGACGCTCGACGACTTGAAAAAGCTCTACCC
CGAGCCGGAACTCGAACGCTTCACAAAACAAACGCCCGCCACGATCGACGACCTGTACGAACGCGTTCGCGACGACGCAC
GGCGCGGCTTCGCGATCAGCGAGTCGTCATTCGAACGCGGCATTTCGGTGGTAAGCGCGCCGGTGCGCAACGACGCGGGC
CGCATCGTCGCGGTGATCACAACGACGATTCCACGTCACGAGATCGACGCTTCGCTGCTCGACAGCGGCTTGATCGAAAA
GGTCCGCCGCGCGGCTGACGAACTGTCGCAGCGGCTCAACTATCGGCCGAAGGGCAGCCCGAACGCGGGCACGAAATACA
TGAAGGCACTGGGGCTCAAATGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A160FVE6

Antitoxin

Source ID Structure

References