Detailed information of TA system TA061515

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): relBE/upstrm_HI1419-dnstrm_HI1420
• Location: 2478691..2479295
• Replicon: chromosome
• Accession: NZ_CP014579
• Organism: Paraburkholderia phytofirmans OLGA172

Toxin (Protein)

• Gene name: relE
• Uniprot ID: -
• Locus tag: AYM40_RS31050
• Protein ID: WP_172161367.1
• Coordinates: 2478691..2478996 (+)
• Length: 102 a.a.

Antitoxin (Protein)

• Gene name: relB
• Uniprot ID: A0A160FUA1
• Locus tag: AYM40_RS31055
• Protein ID: WP_063499837.1
• Coordinates: 2478993..2479295 (+)
• Length: 101 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
AYM40_RS31020	2474404..2475972	+	1569	WP_063500823.1	MFS transporter	-
AYM40_RS31025	2476059..2476331	-	273	WP_063499832.1	hypothetical protein	-
AYM40_RS31030	2476397..2476828	-	432	WP_063499833.1	DoxX family protein	-
AYM40_RS31035	2477089..2477544	-	456	WP_063499834.1	ribose ABC transporter	-
AYM40_RS31040	2477709..2477927	-	219	Protein_2169	hypothetical protein	-
AYM40_RS31045	2477963..2478331	-	369	WP_063499835.1	nuclear transport factor 2 family protein	-
AYM40_RS31050	2478691..2478996	+	306	WP_172161367.1	type II toxin-antitoxin system RelE/ParE family toxin	Toxin
AYM40_RS31055	2478993..2479295	+	303	WP_063499837.1	putative addiction module antidote protein	Antitoxin
AYM40_RS31060	2479416..2480330	+	915	WP_063499838.1	helix-turn-helix transcriptional regulator	-
AYM40_RS31065	2480472..2481002	+	531	WP_063499839.1	GNAT family N-acetyltransferase	-
AYM40_RS39390	2481085..2481316	+	232	Protein_2175	YeeE/YedE family protein	-
AYM40_RS31070	2481839..2482159	+	321	WP_035558891.1	flagellar transcriptional regulator FlhD	-
AYM40_RS31075	2482174..2482743	+	570	WP_028194931.1	flagellar transcriptional regulator FlhC	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin HigB-like (13-88)

Antitoxin

• Uncharacterized protein HI1420 (5-92)

Sequences

Toxin

Protein

• Length: 102 a.a.
• Molecular weight: 11488.26 Da
• Isoelectric Point: 9.5356

>T61515 WP_172161367.1 NZ_CP014579:2478691-2478996 [Paraburkholderia phytofirmans OLGA172]
VYTVNRTEEFDSWLAGLADLRARAKILVRVRRAERGHFGDVKLLEDGVSEMRIDCGPGYRVYFAREGRMVYLLLCGGDKS
TQPADIKHAKSMWAAIRKELS

Nucleotide

• Length: 306 bp

>T61515 NZ_CP014579:2478691-2478996 [Paraburkholderia phytofirmans OLGA172]
GTGTACACGGTCAACCGCACCGAGGAATTCGACAGCTGGCTTGCCGGCCTCGCAGACTTAAGAGCGAGGGCAAAAATCCT
GGTGCGGGTCCGGCGTGCGGAGCGAGGTCATTTCGGCGACGTAAAGCTGCTGGAAGACGGTGTGTCCGAGATGCGCATCG
ATTGCGGTCCCGGCTATCGGGTCTACTTCGCGCGCGAAGGGCGCATGGTGTACCTGCTGCTCTGCGGTGGCGACAAGTCC
ACGCAGCCGGCCGACATCAAGCATGCCAAATCAATGTGGGCAGCAATCAGAAAGGAACTGTCATGA

Antitoxin

Protein

• Length: 101 a.a.
• Molecular weight: 10583.22 Da
• Isoelectric Point: 6.4685

>AT61515 WP_063499837.1 NZ_CP014579:2478993-2479295 [Paraburkholderia phytofirmans OLGA172]
MSKVKTARFDASHYLDSEEMIAEYLNAALEEGDADLLLAAIADIAKARGIAKVAADAGLGRESLYKTLAPGSKPRMDTVF
KLLRALGVKLNAVPEGVAHA

Nucleotide

• Length: 303 bp

>AT61515 NZ_CP014579:2478993-2479295 [Paraburkholderia phytofirmans OLGA172]
ATGAGCAAAGTCAAAACCGCACGGTTCGACGCATCGCACTACCTCGATAGCGAGGAAATGATCGCTGAATATCTCAACGC
TGCACTGGAAGAAGGCGACGCCGACCTCCTCCTCGCCGCGATCGCCGACATCGCAAAAGCACGCGGCATCGCGAAGGTCG
CGGCTGACGCCGGGCTCGGGCGCGAAAGCCTCTATAAAACACTCGCGCCGGGCTCCAAACCGCGCATGGATACGGTGTTC
AAACTGCTTCGGGCGCTGGGCGTCAAACTCAACGCCGTGCCGGAAGGTGTGGCGCACGCCTGA

Structures

Antitoxin

• AlphaFold DB: A0A160FUA1