Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/VapC-VapB
Location 2446355..2446920 Replicon chromosome
Accession NZ_CP014579
Organism Paraburkholderia phytofirmans OLGA172

Toxin (Protein)


Gene name vapC Uniprot ID A0A160FU78
Locus tag AYM40_RS30885 Protein ID WP_063499808.1
Coordinates 2446355..2446726 (-) Length 124 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID A0A167WGH8
Locus tag AYM40_RS30890 Protein ID WP_063499809.1
Coordinates 2446723..2446920 (-) Length 66 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
AYM40_RS30865 2441995..2442996 - 1002 WP_063499806.1 ABC transporter permease -
AYM40_RS30870 2443000..2444730 - 1731 WP_082855523.1 sugar ABC transporter ATP-binding protein -
AYM40_RS30875 2444812..2445786 - 975 WP_063499807.1 sugar ABC transporter substrate-binding protein -
AYM40_RS30880 2445989..2446249 + 261 Protein_2137 LysR family transcriptional regulator -
AYM40_RS30885 2446355..2446726 - 372 WP_063499808.1 type II toxin-antitoxin system VapC family toxin Toxin
AYM40_RS30890 2446723..2446920 - 198 WP_063499809.1 type II toxin-antitoxin system VapB family antitoxin Antitoxin
AYM40_RS30895 2447499..2448503 + 1005 WP_063499810.1 sugar ABC transporter substrate-binding protein -
AYM40_RS30900 2448607..2449593 + 987 WP_063499811.1 ABC transporter permease -
AYM40_RS30905 2449613..2450410 + 798 WP_063499812.1 sugar ABC transporter ATP-binding protein -
AYM40_RS30910 2450441..2451667 + 1227 WP_063499813.1 ROK family transcriptional regulator -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(2-113)

Antitoxin

Bacterial antitoxin of type II TA system, VapB

(1-44)


Sequences

Toxin        


Download         Length: 124 a.a.        Molecular weight: 13606.73 Da        Isoelectric Point: 4.8728

>T61514 WP_063499808.1 NZ_CP014579:c2446726-2446355 [Paraburkholderia phytofirmans OLGA172]
MILVDTSVWIDHINASDSMLISLLAEERVLAHPYVIGEISLGSLRDRDVVLGALLDLPRAPVATPEETFYLIEREGLFNR
GIGYVDTSLLASVRLQPGTTLWTRDKRLKKVADELNLGAVLAH

Download         Length: 372 bp

>T61514 NZ_CP014579:c2446726-2446355 [Paraburkholderia phytofirmans OLGA172]
ATGATTCTTGTCGACACGTCGGTCTGGATTGACCATATCAACGCCTCTGATTCCATGCTGATTAGCCTGCTTGCCGAGGA
GCGCGTGCTGGCTCATCCCTATGTGATAGGCGAGATTTCGCTCGGTAGTCTGCGTGACCGTGACGTCGTGCTTGGCGCGT
TGCTCGATCTGCCGCGCGCGCCAGTTGCAACGCCGGAGGAGACGTTTTATCTGATCGAGCGCGAAGGTTTGTTCAATCGC
GGAATCGGATATGTCGATACATCGCTGTTGGCATCCGTGCGCCTACAGCCCGGCACCACTCTCTGGACACGCGACAAGCG
GTTGAAGAAGGTTGCCGATGAACTCAATCTCGGCGCGGTGCTCGCGCATTAG

Antitoxin


Download         Length: 66 a.a.        Molecular weight: 7090.13 Da        Isoelectric Point: 10.3509

>AT61514 WP_063499809.1 NZ_CP014579:c2446920-2446723 [Paraburkholderia phytofirmans OLGA172]
MRTTISLDDDLIAKAQAYTGVEEKTALVREALKALIQREAAKRLANLGGSQPGIKGAPRRRQDVE

Download         Length: 198 bp

>AT61514 NZ_CP014579:c2446920-2446723 [Paraburkholderia phytofirmans OLGA172]
ATGCGCACGACTATTTCGCTTGATGACGACTTGATCGCCAAGGCTCAAGCCTATACAGGCGTGGAGGAAAAAACGGCACT
CGTGCGTGAAGCGCTAAAGGCTTTGATCCAGCGTGAAGCCGCGAAACGACTCGCGAATCTTGGCGGTAGCCAACCGGGCA
TCAAGGGCGCGCCGCGTCGGCGGCAGGACGTCGAATGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A160FU78

Antitoxin

Source ID Structure
AlphaFold DB A0A167WGH8

References