Detailed information of TA system TA061509

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): hipBA/HipA-couple_hipB
• Location: 348599..350364
• Replicon: chromosome
• Accession: NZ_CP014579
• Organism: Paraburkholderia phytofirmans OLGA172

Toxin (Protein)

• Gene name: hipA
• Uniprot ID: -
• Locus tag: AYM40_RS21930
• Protein ID: WP_201788184.1
• Coordinates: 348599..349969 (-)
• Length: 457 a.a.

Antitoxin (Protein)

• Gene name: hipB
• Uniprot ID: A0A160FQP5
• Locus tag: AYM40_RS21935
• Protein ID: WP_063498377.1
• Coordinates: 349969..350364 (-)
• Length: 132 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
AYM40_RS21915	344980..346338	+	1359	WP_063500618.1	hypothetical protein	-
AYM40_RS41960	346625..346783	+	159	WP_181448452.1	hypothetical protein	-
AYM40_RS21920	347219..347530	+	312	WP_063498375.1	hypothetical protein	-
AYM40_RS21925	347640..348593	+	954	WP_181448453.1	3-hydroxyacyl-CoA dehydrogenase family protein	-
AYM40_RS21930	348599..349969	-	1371	WP_201788184.1	type II toxin-antitoxin system HipA family toxin	Toxin
AYM40_RS21935	349969..350364	-	396	WP_063498377.1	helix-turn-helix transcriptional regulator	Antitoxin
AYM40_RS21940	350943..351377	+	435	WP_063498378.1	cupin domain-containing protein	-
AYM40_RS21945	351425..352897	-	1473	WP_063498379.1	polyhydroxyalkanoate depolymerase	-
AYM40_RS21950	353117..353770	+	654	WP_063498380.1	glutathione S-transferase family protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• HipA, N-terminal subdomain 1 (11-111)

Antitoxin

• Cro/C1-type helix-turn-helix domain (18-66)

Sequences

Toxin

Protein

• Length: 457 a.a.
• Molecular weight: 50422.13 Da
• Isoelectric Point: 6.6628

>T61509 WP_201788184.1 NZ_CP014579:c349969-348599 [Paraburkholderia phytofirmans OLGA172]
IMARRSQTQRLDIWMNGLPVGYWEKAREGDRLSYLDEWIEDEQGRPLSLSMPFTPGNQPYRGDVVSAFFDNLLPDSDAIR
RRLAQRHRAGSTNAFDLLVALGRDCVGAIQLLPPDEQPTDLYGISGTPLSELQIAQLLRNATSAAPLGQYDSGADLRLSI
AGAQEKTALLRHDEQWIYPTGSTPTTHIFKLPLGLVGNMQADMRTSIENEWLCSKIVSAYGLPAANCEIATFEDQKALVV
ERFDRRLSRDASWIVRLPQEDMCQATGKPSHLKYQADGGPGIAEIMDVLLGSETADQDRRQFFKAQLVFWLLAATDGHAK
NFSIFHLPGGLYRSTPLYDVLSAHPIIGPGRNQIARQKAKMAMAIRGSTNHYLIDKVQRRHWIEQARQVGLGSETSQDII
AEVVNATDHVISAVDAVVPSGFPDGLAESILGGVGKQRDKLVAASRLRENARSTRN

Nucleotide

• Length: 1371 bp

>T61509 NZ_CP014579:c349969-348599 [Paraburkholderia phytofirmans OLGA172]
ATCATGGCGCGCCGCTCTCAGACGCAACGACTCGACATCTGGATGAACGGCCTGCCCGTCGGCTACTGGGAAAAGGCACG
GGAAGGGGACCGCCTGAGTTATCTCGACGAGTGGATCGAAGATGAACAGGGCCGCCCTCTTTCCCTATCGATGCCGTTCA
CGCCCGGGAATCAACCGTACCGTGGAGACGTGGTCAGCGCATTTTTCGACAATTTGCTTCCCGATAGCGATGCGATCCGC
CGGCGATTAGCCCAACGGCATCGCGCGGGCAGCACGAATGCTTTTGACCTGCTGGTAGCGCTTGGCCGCGACTGCGTCGG
CGCGATCCAACTACTCCCACCTGATGAGCAACCCACCGATCTATACGGCATCTCCGGAACACCGTTATCCGAGTTGCAGA
TTGCGCAGCTGCTGCGCAATGCCACTTCAGCGGCGCCGCTCGGCCAATACGATAGTGGTGCGGATCTGAGGTTATCGATT
GCTGGCGCACAGGAGAAAACGGCGCTGCTGCGCCACGATGAACAGTGGATCTACCCGACCGGCAGCACGCCGACCACGCA
TATCTTCAAGCTCCCGCTCGGCCTGGTTGGCAATATGCAGGCGGACATGCGGACCTCGATCGAAAACGAATGGCTGTGCT
CAAAAATCGTATCGGCGTATGGACTCCCCGCGGCGAACTGCGAGATTGCAACGTTCGAGGATCAGAAAGCGCTCGTGGTC
GAGCGCTTCGACCGCAGGCTGTCGAGGGACGCGAGCTGGATTGTGCGCCTTCCGCAGGAAGACATGTGCCAGGCCACCGG
AAAGCCCTCACATCTGAAGTATCAAGCCGACGGTGGACCAGGCATCGCTGAGATCATGGATGTATTGCTAGGCTCGGAAA
CCGCGGATCAGGATCGGCGACAGTTCTTCAAGGCTCAACTCGTGTTCTGGCTACTCGCAGCAACGGATGGGCATGCGAAG
AACTTCAGCATTTTTCATCTGCCCGGGGGGTTGTACCGGTCGACGCCACTTTACGACGTGCTATCCGCACATCCGATCAT
TGGTCCTGGGCGCAATCAGATTGCGCGTCAGAAGGCGAAGATGGCAATGGCTATTCGTGGCAGTACCAATCACTATCTGA
TCGACAAGGTCCAGCGGCGGCACTGGATCGAACAGGCCCGGCAGGTTGGGTTGGGTAGCGAGACCTCGCAGGACATTATT
GCTGAAGTGGTTAACGCGACTGATCATGTGATCAGCGCGGTGGATGCGGTGGTGCCCTCGGGATTTCCGGACGGGCTGGC
CGAATCGATTCTGGGTGGGGTTGGGAAGCAGCGGGACAAGTTGGTCGCGGCGTCGAGACTCCGGGAAAATGCCCGGTCGA
CGCGCAACTGA

Antitoxin

Protein

• Length: 132 a.a.
• Molecular weight: 14155.36 Da
• Isoelectric Point: 11.4994

>AT61509 WP_063498377.1 NZ_CP014579:c350364-349969 [Paraburkholderia phytofirmans OLGA172]
MDYAIKTLSQLRPILLGFRKSAGLTQAAVAELLGITQQSYAQLEANPASASVERLFKVMRLLNVELRMSQASSAPGSGPA
QTDTSKLQRQIPAARKVKPPSAPNRADRAPKASSSKQPLGAITTKKKRENW

Nucleotide

• Length: 396 bp

>AT61509 NZ_CP014579:c350364-349969 [Paraburkholderia phytofirmans OLGA172]
ATGGATTACGCCATCAAGACGCTAAGTCAGCTCCGCCCCATTCTGCTGGGCTTCCGCAAGTCCGCAGGGCTCACACAAGC
TGCAGTGGCCGAACTGCTAGGCATCACCCAGCAAAGCTACGCGCAACTGGAGGCCAATCCGGCATCGGCGAGTGTCGAGC
GGCTTTTTAAAGTCATGCGTTTGCTGAACGTGGAATTGCGTATGAGCCAAGCGTCGTCCGCGCCAGGCAGTGGACCGGCG
CAGACCGATACGTCGAAGCTTCAACGGCAGATCCCCGCCGCCAGGAAAGTGAAACCTCCGTCGGCCCCCAACCGCGCAGA
CCGAGCTCCGAAGGCGTCGAGCTCGAAACAACCTCTTGGGGCAATCACAACCAAAAAGAAACGGGAAAACTGGTAA

Structures

Antitoxin

• AlphaFold DB: A0A160FQP5