Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) hicAB/HicA-HicB
Location 4435349..4435938 Replicon chromosome
Accession NZ_CP014578
Organism Paraburkholderia phytofirmans OLGA172

Toxin (Protein)


Gene name hicA Uniprot ID A0A160FNY2
Locus tag AYM40_RS19630 Protein ID WP_063497635.1
Coordinates 4435349..4435531 (+) Length 61 a.a.

Antitoxin (Protein)


Gene name hicB Uniprot ID A0A160FP01
Locus tag AYM40_RS19635 Protein ID WP_063497636.1
Coordinates 4435528..4435938 (+) Length 137 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
AYM40_RS19600 4430593..4431324 - 732 WP_063497629.1 flagellar hook assembly protein FlgD -
AYM40_RS19605 4431335..4431760 - 426 WP_063497630.1 flagellar basal body rod protein FlgC -
AYM40_RS19610 4431870..4432364 - 495 WP_063497631.1 flagellar basal body rod protein FlgB -
AYM40_RS19615 4432582..4433934 + 1353 WP_063497632.1 flagellar basal body P-ring formation protein FlgA -
AYM40_RS19620 4434145..4434498 + 354 WP_063497633.1 flagellar biosynthesis anti-sigma factor FlgM -
AYM40_RS19625 4434593..4435039 + 447 WP_063497634.1 flagellar protein FlgN -
AYM40_RS19630 4435349..4435531 + 183 WP_063497635.1 type II toxin-antitoxin system HicA family toxin Toxin
AYM40_RS19635 4435528..4435938 + 411 WP_063497636.1 type II toxin-antitoxin system HicB family antitoxin Antitoxin
AYM40_RS19640 4435999..4436733 - 735 WP_063497637.1 RNA polymerase sigma factor FliA -
AYM40_RS19645 4436762..4437631 - 870 WP_063497638.1 AAA family ATPase -
AYM40_RS19650 4437624..4439540 - 1917 WP_063497639.1 flagellar biosynthesis protein FlhF -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

HicA mRNA interferase family

(4-59)

Antitoxin

HicB-like antitoxin of toxin-antitoxin system

(6-129)


Sequences

Toxin        


Download         Length: 61 a.a.        Molecular weight: 6571.66 Da        Isoelectric Point: 11.7053

>T61508 WP_063497635.1 NZ_CP014578:4435349-4435531 [Paraburkholderia phytofirmans OLGA172]
MNSAEVVKVIQADGWRLVRTSGSHHHFRHAVKAGLVTIPHPRKDLPPGTLNSILKQAGLK

Download         Length: 183 bp

>T61508 NZ_CP014578:4435349-4435531 [Paraburkholderia phytofirmans OLGA172]
ATGAACAGTGCCGAGGTCGTCAAAGTGATTCAAGCGGATGGCTGGCGGCTGGTCCGAACATCGGGCAGCCACCATCATTT
CCGGCACGCGGTAAAAGCCGGTCTCGTGACCATCCCGCATCCGAGGAAAGATCTTCCGCCCGGCACACTGAACAGCATCT
TGAAACAGGCAGGCCTGAAATGA

Antitoxin


Download         Length: 137 a.a.        Molecular weight: 14752.70 Da        Isoelectric Point: 4.9300

>AT61508 WP_063497636.1 NZ_CP014578:4435528-4435938 [Paraburkholderia phytofirmans OLGA172]
MKNLIFPIAIEPGDTHHAFGVVVPDIPGCHSAGDSLEEAYANAKAAIEAHLDTLLDEGLPIPNRLTLDEHRRNPDYAGFT
WGFVTTRNIPALKKAVRINISLPEALVHDIDAYAEARGMSRSAFLALAAEHEMADA

Download         Length: 411 bp

>AT61508 NZ_CP014578:4435528-4435938 [Paraburkholderia phytofirmans OLGA172]
ATGAAGAACCTGATTTTCCCGATCGCGATCGAGCCTGGTGACACGCACCATGCGTTCGGCGTGGTCGTCCCCGACATTCC
GGGTTGTCATTCGGCGGGTGATTCGCTGGAAGAAGCCTACGCCAACGCGAAAGCAGCGATCGAGGCGCATCTGGACACGC
TGCTCGACGAAGGGTTGCCGATTCCCAACCGGCTGACGCTGGACGAGCATCGGCGCAATCCGGACTACGCGGGTTTTACT
TGGGGTTTTGTCACCACGCGGAATATTCCGGCGCTGAAAAAGGCGGTGCGCATCAATATCTCGCTGCCCGAGGCGCTGGT
TCATGATATCGACGCTTACGCAGAGGCGCGCGGCATGTCGCGCTCAGCGTTTCTCGCGCTGGCCGCGGAGCATGAAATGG
CGGACGCGTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A160FNY2

Antitoxin

Source ID Structure
AlphaFold DB A0A160FP01

References