Detailed information of TA system TA061503

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): FicTA/Fic(toxin)
• Location: 18560..19428
• Replicon: plasmid mp2
• Accession: NZ_CP014570
• Organism: Campylobacter fetus subsp. venerealis strain 01/165

Toxin (Protein)

• Gene name: Fic
• Uniprot ID: -
• Locus tag: CFVI01165_RS09750
• Protein ID: WP_065439552.1
• Coordinates: 18787..19428 (+)
• Length: 214 a.a.

Antitoxin (Protein)

• Gene name: Fti
• Uniprot ID: S3XPH8
• Locus tag: CFVI01165_RS09745
• Protein ID: WP_016647519.1
• Coordinates: 18560..18790 (+)
• Length: 77 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
CFVI01165_RS10090	13581..13721	+	141	WP_173647264.1	hypothetical protein	-
CFVI01165_RS09730	13718..15891	+	2174	Protein_18	DUF1738 domain-containing protein	-
CFVI01165_RS09735	15901..17724	+	1824	WP_065439551.1	type IV secretory system conjugative DNA transfer family protein	-
CFVI01165_RS09740	17733..18452	+	720	WP_024962041.1	conjugal transfer protein TraL	-
CFVI01165_RS09745	18560..18790	+	231	WP_016647519.1	hypothetical protein	Antitoxin
CFVI01165_RS09750	18787..19428	+	642	WP_065439552.1	Fic family protein	Toxin
CFVI01165_RS09755	19428..19949	+	522	WP_016647521.1	signal peptidase I	-
CFVI01165_RS09760	19942..20337	+	396	WP_016647522.1	hypothetical protein	-
CFVI01165_RS09765	20577..21302	-	726	WP_065439553.1	NYN domain-containing protein	-
CFVI01165_RS09770	21465..21671	-	207	WP_016647524.1	hypothetical protein	-
CFVI01165_RS09775	21743..22426	-	684	WP_016647525.1	AAA family ATPase	-
CFVI01165_RS09950	22518..22850	-	333	WP_148660273.1	hypothetical protein	-
CFVI01165_RS10000	23007..23639	-	633	WP_159426677.1	hypothetical protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Non-Mobilizable plasmid	-	-	1..27417	27417

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Fido domain (46-157)

Antitoxin

No domain identified.

Sequences

Toxin

Protein

• Length: 214 a.a.
• Molecular weight: 24964.77 Da
• Isoelectric Point: 10.1619

>T61503 WP_065439552.1 NZ_CP014570:18787-19428 [Campylobacter fetus subsp. venerealis]
VNNIFEELITNNKLGIKNYDKFEKTSRKYTANRIFEIQKNPIKGNFDYQHLKDIHKFIFQDVFEWAGKDRAELRLFDTFA
KRSPFNPNYIQNFVPGKELKKYSKIIFDELKEQNYLKNSKDLNSFAKGMANFLMELNALHPFREGNGRTQRIFCNELAKN
AGYKMDLNLISNEKMLIASVEASQIKPAKLEALIKANLKSFKQNLTKEQGIFF

Nucleotide

• Length: 642 bp

>T61503 NZ_CP014570:18787-19428 [Campylobacter fetus subsp. venerealis]
GTGAATAATATCTTTGAAGAGCTAATTACAAACAATAAATTAGGAATTAAAAATTATGATAAATTTGAAAAAACAAGTAG
AAAATATACTGCCAATAGAATATTTGAAATTCAAAAAAATCCCATTAAGGGAAATTTTGATTATCAGCACTTAAAAGATA
TCCATAAATTTATTTTCCAAGATGTTTTTGAATGGGCTGGAAAAGATAGAGCTGAGCTTAGACTATTTGATACTTTTGCT
AAACGATCACCATTTAATCCAAATTATATACAAAATTTCGTTCCAGGTAAAGAACTTAAAAAATATTCAAAAATAATTTT
TGATGAGTTAAAAGAACAAAACTATCTAAAAAATAGCAAAGATTTAAATTCTTTTGCAAAAGGTATGGCAAATTTTTTAA
TGGAGTTAAACGCACTTCATCCATTCCGTGAAGGAAATGGTAGGACGCAGCGGATATTTTGCAATGAATTAGCTAAAAAT
GCAGGATATAAAATGGATTTAAATTTAATTTCAAATGAAAAAATGCTAATTGCAAGTGTTGAAGCTTCTCAAATAAAACC
TGCAAAACTCGAAGCACTTATAAAAGCAAATTTAAAGAGCTTTAAACAAAATTTAACCAAAGAACAAGGAATATTTTTTT
AA

Antitoxin

Protein

• Length: 77 a.a.
• Molecular weight: 8772.89 Da
• Isoelectric Point: 4.4929

>AT61503 WP_016647519.1 NZ_CP014570:18560-18790 [Campylobacter fetus subsp. venerealis]
MTYPEVNSLEESLAILKKYKNELSKDDYDNIKSVIGSHAIENEYLNEIDIEMLVDKAINNRTTEESINRLKNKGLL

Nucleotide

• Length: 231 bp

>AT61503 NZ_CP014570:18560-18790 [Campylobacter fetus subsp. venerealis]
ATGACTTACCCAGAAGTTAATAGTTTAGAAGAAAGTTTGGCGATACTAAAAAAATATAAAAATGAGCTTAGTAAAGATGA
TTATGATAATATAAAATCAGTTATAGGCTCTCACGCAATAGAAAATGAGTATTTAAATGAAATAGATATAGAAATGCTTG
TAGATAAGGCAATAAATAATAGAACAACCGAAGAATCAATAAACAGACTAAAAAATAAAGGCTTATTGTGA

Structures

Antitoxin

• AlphaFold DB: S3XPH8