Detailed information of TA system TA061502

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): tsbAT/-
• Location: 1983173..1983968
• Replicon: chromosome
• Accession: NZ_CP014567
• Organism: Staphylococcus hominis strain C34847

Toxin (Protein)

• Gene name: tsbT
• Uniprot ID: -
• Locus tag: AZE34_RS09905
• Protein ID: WP_249339582.1
• Coordinates: 1983795..1983968 (+)
• Length: 58 a.a.

Antitoxin (Protein)

• Gene name: tsbA
• Uniprot ID: A0A4Q9WMK1
• Locus tag: AZE34_RS09900
• Protein ID: WP_017176400.1
• Coordinates: 1983173..1983772 (+)
• Length: 200 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
AZE34_RS09880 (AZE34_09665)	1978988..1980442	+	1455	WP_017176404.1	ABC transporter substrate-binding protein/permease	-
AZE34_RS09885 (AZE34_09670)	1980435..1981157	+	723	WP_017176403.1	amino acid ABC transporter ATP-binding protein	-
AZE34_RS09890 (AZE34_09675)	1981419..1982540	+	1122	WP_017176402.1	tRNA epoxyqueuosine(34) reductase QueG	-
AZE34_RS09895 (AZE34_09680)	1982543..1983013	+	471	WP_017176401.1	tRNA (uridine(34)/cytosine(34)/5- carboxymethylaminomethyluridine(34)-2'-O)- methyltransferase TrmL	-
AZE34_RS09900 (AZE34_09685)	1983173..1983772	+	600	WP_017176400.1	glucosamine-6-phosphate isomerase	Antitoxin
AZE34_RS09905	1983795..1983968	+	174	WP_249339582.1	SAS053 family protein	Toxin
AZE34_RS09910 (AZE34_09690)	1984079..1984471	+	393	WP_017176398.1	hypothetical protein	-
AZE34_RS09915 (AZE34_09695)	1984611..1985996	+	1386	WP_017176397.1	class II fumarate hydratase	-
AZE34_RS09920 (AZE34_09700)	1986075..1986899	-	825	WP_017176396.1	RluA family pseudouridine synthase	-
AZE34_RS09925 (AZE34_09705)	1987037..1988146	+	1110	WP_017176395.1	GAF domain-containing sensor histidine kinase	-
AZE34_RS09930 (AZE34_09710)	1988161..1988784	+	624	WP_017176394.1	response regulator transcription factor	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

No domain identified.

Antitoxin

• Glucosamine-6-phosphate isomerase (130-195)

Sequences

Toxin

Protein

• Length: 58 a.a.
• Molecular weight: 6739.15 Da
• Isoelectric Point: 3.9837

>T61502 WP_249339582.1 NZ_CP014567:1983795-1983968 [Staphylococcus hominis]
IFMSKDSKRNYHEDENAMVQNMDDLEALGKEMEQISEENDEDKYNQTHDSEARSDLN

Nucleotide

• Length: 174 bp

>T61502 NZ_CP014567:1983795-1983968 [Staphylococcus hominis]
ATTTTTATGAGTAAAGATAGTAAACGTAATTATCATGAAGACGAAAATGCAATGGTTCAAAATATGGATGATTTAGAAGC
ATTAGGAAAAGAAATGGAACAGATTTCTGAAGAAAATGATGAAGATAAATATAATCAAACACATGATTCAGAAGCGCGTT
CAGATTTAAATTAA

Antitoxin

Protein

• Length: 200 a.a.
• Molecular weight: 22375.22 Da
• Isoelectric Point: 4.9712

>AT61502 WP_017176400.1 NZ_CP014567:1983173-1983772 [Staphylococcus hominis]
MAMNFKVFEDKQHAADYAGDIIRKQFNNNPTTIAGFHLNKDSAPVLDELKKSVDRNAVDFSQINILDYDDNHSFYEALGV
PSEQVYSISLDDDAESLINDRIKTKENKGKLTLQVVSIDNSGHLDVNIRQGLMKAREIILVVTGAEKSEVIKRLYEENGK
SNFLPADLKVHRMVTVVLDRAAADGLPEDVKEYFTARFA

Nucleotide

• Length: 600 bp

>AT61502 NZ_CP014567:1983173-1983772 [Staphylococcus hominis]
ATGGCAATGAATTTTAAAGTATTCGAAGATAAACAACATGCAGCAGACTATGCTGGAGATATTATTAGAAAACAATTTAA
CAATAACCCAACTACCATTGCTGGTTTCCATTTAAACAAGGATTCTGCACCTGTATTAGATGAATTAAAAAAATCAGTTG
ATCGTAACGCTGTAGATTTTAGTCAAATTAATATTCTTGACTATGACGATAATCATTCGTTCTATGAAGCTTTAGGTGTA
CCTTCTGAGCAAGTATATTCTATTAGTCTTGATGATGATGCTGAATCATTAATCAATGATAGAATTAAAACAAAAGAAAA
TAAAGGAAAACTTACTTTACAAGTTGTTTCAATTGATAACTCTGGACATTTAGATGTTAATATTCGTCAAGGTTTGATGA
AGGCACGCGAAATTATCTTAGTTGTAACTGGTGCTGAAAAAAGTGAAGTTATCAAACGATTATATGAAGAAAATGGTAAA
TCAAACTTTTTACCTGCTGATTTAAAAGTACATCGTATGGTAACAGTTGTTTTAGACAGAGCTGCTGCTGATGGATTACC
AGAAGACGTTAAAGAATACTTCACAGCGAGATTTGCATAA

Structures

Antitoxin

• AlphaFold DB: A0A4Q9WMK1