Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) mazEF/MazF(toxin)
Location 1854045..1854574 Replicon chromosome
Accession NZ_CP014567
Organism Staphylococcus hominis strain C34847

Toxin (Protein)


Gene name mazF Uniprot ID A0A4Q9WNP6
Locus tag AZE34_RS09140 Protein ID WP_017174798.1
Coordinates 1854212..1854574 (+) Length 121 a.a.

Antitoxin (Protein)


Gene name mazE Uniprot ID A0A1L8Y5N2
Locus tag AZE34_RS09135 Protein ID WP_002448681.1
Coordinates 1854045..1854215 (+) Length 57 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
AZE34_RS09110 (AZE34_08920) 1849950..1850429 + 480 WP_017174793.1 PH domain-containing protein -
AZE34_RS09115 (AZE34_08925) 1850419..1851921 + 1503 WP_017174794.1 PH domain-containing protein -
AZE34_RS09120 (AZE34_08930) 1851914..1852390 + 477 WP_017174795.1 PH domain-containing protein -
AZE34_RS09125 (AZE34_08935) 1852418..1852771 + 354 WP_017174796.1 holo-ACP synthase -
AZE34_RS09130 (AZE34_08940) 1852814..1853959 + 1146 WP_017174797.1 alanine racemase -
AZE34_RS09135 (AZE34_08945) 1854045..1854215 + 171 WP_002448681.1 type II toxin-antitoxin system antitoxin MazE Antitoxin
AZE34_RS09140 (AZE34_08950) 1854212..1854574 + 363 WP_017174798.1 type II toxin-antitoxin system PemK/MazF family toxin Toxin
AZE34_RS09145 (AZE34_08955) 1854946..1855947 + 1002 WP_017174799.1 PP2C family protein-serine/threonine phosphatase -
AZE34_RS09150 (AZE34_08960) 1856033..1856359 + 327 WP_002448686.1 anti-sigma factor antagonist -
AZE34_RS09155 (AZE34_08965) 1856388..1856840 + 453 WP_049335593.1 anti-sigma B factor RsbW -
AZE34_RS09160 (AZE34_08970) 1856815..1857585 + 771 WP_017174800.1 RNA polymerase sigma factor SigB -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

mRNA interferase PemK-like

(3-109)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 121 a.a.        Molecular weight: 13580.74 Da        Isoelectric Point: 9.8760

>T61501 WP_017174798.1 NZ_CP014567:1854212-1854574 [Staphylococcus hominis]
MIRRGDVYLADLSPVQGSEQGGVRPVVIIQNDTGNKYSPTVIVAAITGRINKAKIPTHVEIEKKKYRLDKDSVILLEQIR
TLDKKRLKEKLTYLSEDKMKEVDDALDISLGLHDVRPQKN

Download         Length: 363 bp

>T61501 NZ_CP014567:1854212-1854574 [Staphylococcus hominis]
ATGATTAGAAGAGGCGATGTATATTTAGCTGATTTATCACCAGTTCAAGGGTCTGAACAAGGGGGAGTAAGACCTGTAGT
TATCATTCAAAATGATACTGGTAATAAATATAGTCCTACAGTAATCGTTGCTGCGATTACTGGTAGGATTAATAAAGCGA
AAATACCAACACATGTAGAAATAGAAAAGAAAAAATATCGTTTAGATAAAGATTCAGTCATTCTTTTAGAACAAATACGA
ACATTAGATAAAAAAAGATTGAAAGAGAAACTTACATATTTATCAGAAGATAAAATGAAAGAAGTTGACGATGCATTGGA
TATCAGTTTAGGTTTACACGATGTTCGTCCTCAAAAAAATTAG

Antitoxin


Download         Length: 57 a.a.        Molecular weight: 6368.03 Da        Isoelectric Point: 4.0121

>AT61501 WP_002448681.1 NZ_CP014567:1854045-1854215 [Staphylococcus hominis]
MLTFNQNRSHSLEQSLKEGYVQMADLNLSLATEAFPLECEACDCNESYLTSNYKSE

Download         Length: 171 bp

>AT61501 NZ_CP014567:1854045-1854215 [Staphylococcus hominis]
ATGTTAACTTTTAATCAGAATAGAAGCCATAGTCTTGAACAATCATTAAAAGAGGGCTATGTCCAAATGGCCGATTTAAA
CCTCTCCCTAGCAACAGAAGCATTTCCATTAGAATGTGAAGCTTGTGATTGTAACGAATCATATCTTACATCTAATTATA
AAAGTGAATGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A4Q9WNP6

Antitoxin

Source ID Structure
AlphaFold DB A0A1L8Y5N2

References