Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) TsdAT/-
Location 1843029..1843547 Replicon chromosome
Accession NZ_CP014567
Organism Staphylococcus hominis strain C34847

Toxin (Protein)


Gene name TsdT Uniprot ID A0A3S7GWQ7
Locus tag AZE34_RS09080 Protein ID WP_017174788.1
Coordinates 1843338..1843547 (+) Length 70 a.a.

Antitoxin (Protein)


Gene name TsdA Uniprot ID A0A1L8Y5R0
Locus tag AZE34_RS09075 Protein ID WP_002437530.1
Coordinates 1843029..1843322 (+) Length 98 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
AZE34_RS09050 (AZE34_08865) 1838254..1839042 + 789 WP_017175143.1 hydroxyethylthiazole kinase -
AZE34_RS09055 (AZE34_08870) 1839045..1839683 + 639 WP_017175144.1 thiamine phosphate synthase -
AZE34_RS09060 (AZE34_08875) 1839773..1840642 + 870 WP_017175145.1 membrane protein insertase YidC -
AZE34_RS09065 (AZE34_08880) 1840700..1841347 - 648 WP_017174786.1 HD domain-containing protein -
AZE34_RS09070 (AZE34_08885) 1841382..1842866 - 1485 WP_017174787.1 cardiolipin synthase -
AZE34_RS09075 (AZE34_08890) 1843029..1843322 + 294 WP_002437530.1 copper-sensing transcriptional repressor CsoR Antitoxin
AZE34_RS09080 (AZE34_08895) 1843338..1843547 + 210 WP_017174788.1 heavy metal-associated domain-containing protein Toxin
AZE34_RS09085 1843660..1843797 + 138 WP_002437525.1 Lmo0850 family protein -
AZE34_RS09090 (AZE34_08900) 1843958..1845142 - 1185 WP_017174789.1 FtsW/RodA/SpoVE family cell cycle protein -
AZE34_RS09095 (AZE34_08905) 1845518..1846588 + 1071 WP_017174790.1 D-alanine--D-alanine ligase -
AZE34_RS09100 (AZE34_08910) 1846604..1847959 + 1356 WP_017174791.1 UDP-N-acetylmuramoyl-tripeptide--D-alanyl-D- alanine ligase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Heavy metal-associated domain, HMA

(23-67)

Antitoxin

Metal-sensitive transcriptional repressor

(16-92)


Sequences

Toxin        


Download         Length: 70 a.a.        Molecular weight: 8013.16 Da        Isoelectric Point: 4.3178

>T61500 WP_017174788.1 NZ_CP014567:1843338-1843547 [Staphylococcus hominis]
MLNRNIVFIDNIETKEQAQMLNERLLNMIGVHTVSIDIERNMVNVEYETPTNLNSIEKEIYDAGFKVLS

Download         Length: 210 bp

>T61500 NZ_CP014567:1843338-1843547 [Staphylococcus hominis]
ATGTTAAACCGTAATATTGTATTTATAGATAACATTGAAACAAAGGAACAAGCACAAATGTTAAATGAACGTTTGTTAAA
TATGATTGGAGTACATACGGTATCAATCGATATAGAAAGAAATATGGTTAATGTTGAATATGAAACACCTACTAATTTAA
ATAGTATTGAAAAAGAAATTTATGACGCTGGATTTAAAGTACTTTCATAA

Antitoxin


Download         Length: 98 a.a.        Molecular weight: 11231.84 Da        Isoelectric Point: 6.3270

>AT61500 WP_002437530.1 NZ_CP014567:1843029-1843322 [Staphylococcus hominis]
MENQNHAHHSEQVKLNLKSRLNRIEGQVKAINRMIDEDVYCDDVLTQIRATRSALNSVATKLLEHHMKSCIMEKINQGTE
EEAMEELLVTFQKLVKD

Download         Length: 294 bp

>AT61500 NZ_CP014567:1843029-1843322 [Staphylococcus hominis]
TTGGAAAATCAAAATCATGCCCATCATTCTGAGCAAGTTAAATTAAATTTAAAATCTCGATTAAATCGAATAGAAGGACA
AGTTAAAGCAATTAATAGAATGATTGATGAAGACGTCTACTGTGATGATGTATTAACTCAGATAAGAGCAACACGTTCAG
CACTTAATAGTGTTGCTACTAAGTTACTAGAACATCACATGAAAAGTTGTATTATGGAAAAAATAAATCAAGGTACTGAA
GAAGAAGCAATGGAAGAACTACTAGTGACATTTCAAAAACTAGTGAAAGATTAG

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A3S7GWQ7

Antitoxin

Source ID Structure
AlphaFold DB A0A1L8Y5R0

References