Detailed information of TA system TA061499

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): TsaAT/-
• Location: 577235..577703
• Replicon: chromosome
• Accession: NZ_CP014567
• Organism: Staphylococcus hominis strain C34847

Toxin (Protein)

• Gene name: TsaT
• Uniprot ID: A0A4Q9WRX6
• Locus tag: AZE34_RS02780
• Protein ID: WP_017175887.1
• Coordinates: 577515..577703 (+)
• Length: 63 a.a.

Antitoxin (Protein)

• Gene name: TsaA
• Uniprot ID: A0A4Q9WS45
• Locus tag: AZE34_RS02775
• Protein ID: WP_017175886.1
• Coordinates: 577235..577492 (+)
• Length: 86 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
AZE34_RS02735 (AZE34_02705)	572628..573353	-	726	WP_002455566.1	type I 3-dehydroquinate dehydratase	-
AZE34_RS02740 (AZE34_02710)	573515..573937	+	423	WP_002448074.1	organic hydroperoxide resistance protein	-
AZE34_RS02745 (AZE34_02715)	574389..574880	+	492	WP_002448223.1	GNAT family N-acetyltransferase	-
AZE34_RS02750 (AZE34_02720)	574894..575283	-	390	WP_017175882.1	histidine phosphatase family protein	-
AZE34_RS02755 (AZE34_02725)	575305..575553	+	249	WP_242577454.1	GNAT family N-acetyltransferase	-
AZE34_RS02760 (AZE34_02730)	575568..576167	-	600	WP_017175883.1	histidine phosphatase family protein	-
AZE34_RS02765 (AZE34_02735)	576346..576588	+	243	WP_017175884.1	hypothetical protein	-
AZE34_RS02770 (AZE34_02740)	576580..576783	-	204	WP_017175885.1	sterile alpha motif-like domain-containing protein	-
AZE34_RS02775 (AZE34_02745)	577235..577492	+	258	WP_017175886.1	hypothetical protein	Antitoxin
AZE34_RS02780 (AZE34_02750)	577515..577703	+	189	WP_017175887.1	hypothetical protein	Toxin
AZE34_RS02785 (AZE34_02755)	577872..578366	+	495	WP_231451785.1	lipoprotein N-acylation protein LnsA	-
AZE34_RS02790 (AZE34_02760)	578440..579186	+	747	WP_017175889.1	poly-gamma-glutamate hydrolase family protein	-
AZE34_RS02795 (AZE34_02765)	579263..579547	+	285	WP_017175890.1	hypothetical protein	-
AZE34_RS02800 (AZE34_02770)	579703..579930	+	228	WP_017175891.1	hypothetical protein	-
AZE34_RS02805 (AZE34_02775)	580063..580767	+	705	WP_017175892.1	hypothetical protein	-
AZE34_RS02810	580903..581079	+	177	WP_002448052.1	hypothetical protein	-
AZE34_RS02815 (AZE34_02780)	581134..582075	-	942	WP_037541571.1	cation diffusion facilitator family transporter	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Haemolysin expression modulating, HHA (13-69)

Antitoxin

• Biofilm formation regulator YbaJ (1-116)

Sequences

Toxin

Protein

• Length: 63 a.a.
• Molecular weight: 7050.70 Da
• Isoelectric Point: 9.6269

>T61499 WP_017175887.1 NZ_CP014567:577515-577703 [Staphylococcus hominis]
MSTHLTILLWLGIIFVVAASIILGLLLKSKKEERKESYLGFTVIFYIFGFALLIYVLIFGIL

Nucleotide

• Length: 189 bp

>T61499 NZ_CP014567:577515-577703 [Staphylococcus hominis]
ATGAGTACACATTTAACAATTTTACTTTGGCTGGGTATTATATTTGTTGTTGCTGCTTCAATTATATTAGGGTTATTGCT
AAAATCTAAAAAAGAAGAACGTAAAGAATCATATTTAGGCTTTACAGTCATCTTTTATATTTTTGGTTTTGCTTTACTGA
TATATGTACTAATATTTGGTATTTTATAA

Antitoxin

Protein

• Length: 86 a.a.
• Molecular weight: 10069.23 Da
• Isoelectric Point: 4.4986

>AT61499 WP_017175886.1 NZ_CP014567:577235-577492 [Staphylococcus hominis]
MNINKLFWINIMITLLFLGFNITVTYFPKLDDYFWLIPGLIICGLTISFSLIAAILDKNLISEIIFLTNLIIFLYYIYPL
IYNFF

Nucleotide

• Length: 258 bp

>AT61499 NZ_CP014567:577235-577492 [Staphylococcus hominis]
ATGAATATTAATAAATTATTTTGGATTAATATTATGATTACCCTTTTATTTCTAGGTTTTAATATTACTGTCACCTATTT
TCCTAAGTTAGATGATTATTTTTGGCTCATACCTGGTTTAATCATATGTGGCCTTACTATTTCATTCAGTTTAATTGCCG
CTATTTTGGATAAAAACCTTATAAGCGAAATAATTTTTTTAACTAATCTAATCATTTTTTTATATTATATATATCCACTG
ATATATAACTTTTTTTAA

Structures

Toxin

• AlphaFold DB: A0A4Q9WRX6

Antitoxin

• AlphaFold DB: A0A4Q9WS45