Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/PIN(toxin)
Location 2338310..2339005 Replicon chromosome
Accession NZ_CP014566
Organism Mycobacterium tuberculosis variant bovis BCG str. Tokyo 172

Toxin (Protein)


Gene name vapC Uniprot ID O53501
Locus tag AZH48_RS10865 Protein ID WP_003410811.1
Coordinates 2338310..2338744 (-) Length 145 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID G0TMN0
Locus tag AZH48_RS10870 Protein ID WP_003410814.1
Coordinates 2338751..2339005 (-) Length 85 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
AZH48_RS10855 2334464..2337505 + 3042 WP_010950658.1 DEAD/DEAH box helicase -
AZH48_RS10860 2337615..2338331 + 717 WP_003410793.1 SWIM zinc finger family protein -
AZH48_RS10865 2338310..2338744 - 435 WP_003410811.1 type II toxin-antitoxin system VapC family toxin Toxin
AZH48_RS10870 2338751..2339005 - 255 WP_003410814.1 antitoxin Antitoxin
AZH48_RS10875 2339021..2339278 - 258 WP_003410816.1 hypothetical protein -
AZH48_RS10880 2340225..2340521 + 297 WP_003410820.1 PE family protein -
AZH48_RS10885 2340577..2341308 + 732 WP_003900467.1 PPE family protein -
AZH48_RS10890 2341848..2342594 - 747 WP_003901330.1 proteasome subunit alpha -
AZH48_RS10895 2342591..2343466 - 876 WP_003411023.1 proteasome subunit beta -
AZH48_RS10900 2343463..2343657 - 195 WP_003411026.1 ubiquitin-like protein Pup -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain toxin

(1-142)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 145 a.a.        Molecular weight: 15662.08 Da        Isoelectric Point: 7.4681

>T61479 WP_003410811.1 NZ_CP014566:c2338744-2338310 [Mycobacterium tuberculosis variant bovis BCG str. Tokyo 172]
MKIVDANVLLYAVNTTSEHHKPSLRWLDGALSGADRVGFAWVPLLAFVRLATKVGLFPRPLPREAAITQVADWLAAPSAV
LVNPTVRHADILARMLTYVGTGANLVNDAHLAALAVEHRASIVSYDSDFGRFEGVRWDQPPALL

Download         Length: 435 bp

>T61479 NZ_CP014566:c2338744-2338310 [Mycobacterium tuberculosis variant bovis BCG str. Tokyo 172]
ATGAAGATCGTCGACGCGAACGTCTTGCTCTACGCCGTGAACACCACAAGTGAGCACCACAAGCCGTCGCTGCGCTGGCT
TGACGGTGCGCTGTCGGGCGCCGACCGCGTCGGGTTCGCCTGGGTGCCGTTGTTGGCGTTCGTGCGATTGGCGACCAAGG
TGGGGTTGTTCCCCCGTCCGCTTCCGCGGGAGGCGGCCATCACCCAGGTCGCGGATTGGCTAGCCGCACCCAGCGCCGTC
TTGGTGAATCCGACCGTCCGGCACGCCGATATCCTGGCGAGAATGCTGACGTACGTGGGAACCGGTGCCAACCTGGTCAA
CGACGCGCATCTGGCCGCGCTTGCCGTCGAGCATCGCGCCAGCATCGTGTCCTACGACAGTGACTTCGGCCGATTCGAAG
GGGTGCGCTGGGATCAGCCGCCCGCGCTGTTGTGA

Antitoxin


Download         Length: 85 a.a.        Molecular weight: 9417.57 Da        Isoelectric Point: 8.9912

>AT61479 WP_003410814.1 NZ_CP014566:c2339005-2338751 [Mycobacterium tuberculosis variant bovis BCG str. Tokyo 172]
MRTTVTLDDDVEQLVRRRMAERQVSFKKALNDAIRDGASGRPAPSHFSTRTADLGVPAVNLDRALQLAADLEDEELVRRQ
RRGS

Download         Length: 255 bp

>AT61479 NZ_CP014566:c2339005-2338751 [Mycobacterium tuberculosis variant bovis BCG str. Tokyo 172]
ATGCGGACGACTGTCACATTGGATGACGACGTCGAGCAGTTGGTAAGGCGCCGGATGGCCGAGCGGCAAGTGTCCTTCAA
GAAGGCCCTCAACGACGCGATTCGCGACGGCGCCTCCGGGCGACCTGCGCCGAGTCACTTCAGCACCCGCACGGCAGACT
TGGGCGTCCCTGCGGTCAACCTCGACCGGGCCTTGCAGCTTGCGGCCGACCTCGAGGACGAAGAGCTTGTGCGCCGTCAA
CGCCGCGGGTCATAG

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A7U4FB09

Antitoxin

Source ID Structure
AlphaFold DB G0TMN0

References