Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) mazEF/MazF(toxin)
Location 2205736..2206322 Replicon chromosome
Accession NZ_CP014566
Organism Mycobacterium tuberculosis variant bovis BCG str. Tokyo 172

Toxin (Protein)


Gene name mazF Uniprot ID G0TLY3
Locus tag AZH48_RS10275 Protein ID WP_003410010.1
Coordinates 2205736..2206080 (-) Length 115 a.a.

Antitoxin (Protein)


Gene name mazE Uniprot ID P0CL58
Locus tag AZH48_RS10280 Protein ID WP_003410014.1
Coordinates 2206074..2206322 (-) Length 83 a.a.

Genomic Context

AZH48_RS10240AZH48_RS10245AZH48_RS10250AZH48_RS10265AZH48_RS10300AZH48_RS10255AZH48_RS10260AZH48_RS10270AZH48_RS10275AZH48_RS10280AZH48_RS10285AZH48_RS10290AZH48_RS10295
Location: 2201442..2202041 (600 bp)
Type: Others
Protein ID: WP_003409989.1
Location: 2202457..2202885 (429 bp)
Type: Others
Protein ID: WP_003409992.1
Location: 2203111..2203650 (540 bp)
Type: Others
Protein ID: WP_003900446.1
Location: 2205154..2205411 (258 bp)
Type: Others
Protein ID: WP_003410006.1
Location: 2209572..2210339 (768 bp)
Type: Others
Protein ID: WP_003410019.1
Location: 2204170..2204730 (561 bp)
Type: Others
Protein ID: WP_003410001.1
Location: 2204727..2205068 (342 bp)
Type: Others
Protein ID: WP_003410003.1
Location: 2205312..2205647 (336 bp)
Type: Others
Protein ID: WP_003410009.1
Location: 2205736..2206080 (345 bp)
Type: Toxin
Protein ID: WP_003410010.1
Location: 2206074..2206322 (249 bp)
Type: Antitoxin
Protein ID: WP_003410014.1
Location: 2206422..2208737 (2316 bp)
Type: Others
Protein ID: WP_003899120.1
Location: 2208734..2209006 (273 bp)
Type: Others
Protein ID: WP_003410017.1
Location: 2209059..2209415 (357 bp)
Type: Others
Protein ID: WP_003410018.1
ToxinAntitoxinOther genes
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Locus tag
Coordinates
Strand
Size (bp)
Protein ID
Product
Description
AZH48_RS102402201442..2202041+600WP_003409989.1L-lysine exporter-
AZH48_RS102452202457..2202885+429WP_003409992.1cellulose-binding protein-
AZH48_RS102502203111..2203650+540WP_003900446.123S rRNA (adenine(2058)-N(6))-methyltransferase Erm(37)-
AZH48_RS102552204170..2204730-561WP_003410001.1RES family NAD+ phosphorylase-
AZH48_RS102602204727..2205068-342WP_003410003.1DUF2384 domain-containing protein-
AZH48_RS102652205154..2205411+258WP_003410006.1hypothetical protein-
AZH48_RS102702205312..2205647-336WP_003410009.1dehydrogenase-
AZH48_RS102752205736..2206080-345WP_003410010.1type II toxin-antitoxin system toxin endoribonuclease MazF6Toxin
AZH48_RS102802206074..2206322-249WP_003410014.1ribbon-helix-helix protein, CopG familyAntitoxin
AZH48_RS102852206422..2208737-2316WP_003899120.1cation transporter ATPase CptG-
AZH48_RS102902208734..2209006-273WP_003410017.1DUF1490 family protein-
AZH48_RS102952209059..2209415-357WP_003410018.1Cd(II)/Pb(II)-sensing metalloregulatory transcriptional regulator CmtR-
AZH48_RS103002209572..2210339+768WP_003410019.1hemerythrin domain-containing protein-

Associated MGEs

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MGE
detail
Similar
MGEs
Relative
position
MGE Type
Cargo ARG
Virulence gene
Coordinates
Length (bp)
No matching records found


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

mRNA interferase PemK-like

(5-112)

Antitoxin

Ribbon-helix-helix protein, CopG

(5-38)


Sequences

Toxin        


Download         Length: 115 a.a.        Molecular weight: 12230.12 Da        Isoelectric Point: 9.8887

>T61475 WP_003410010.1 NZ_CP014566:c2206080-2205736 [Mycobacterium tuberculosis variant bovis BCG str. Tokyo 172]
VVISRAEIYWADLGPPSGSQPAKRRPVLVIQSDPYNASRLATVIAAVITSNTALAAMPGNVFLPATTTRLPRDSVVNVTA
IVTLNKTDLTDRVGEVPASLMHEVDRGLRRVLDL

Download         Length: 345 bp

>T61475 NZ_CP014566:c2206080-2205736 [Mycobacterium tuberculosis variant bovis BCG str. Tokyo 172]
GTGGTGATTAGTCGTGCCGAGATCTACTGGGCTGACCTCGGGCCGCCATCAGGCAGTCAGCCGGCGAAGCGCCGCCCGGT
GCTCGTAATCCAGTCAGATCCGTACAACGCAAGTCGCCTTGCCACTGTGATCGCAGCGGTGATCACGTCCAATACGGCGC
TGGCGGCAATGCCCGGCAACGTGTTCTTGCCCGCGACCACAACGCGACTGCCACGTGACTCGGTCGTCAACGTCACGGCG
ATTGTCACGCTCAACAAGACTGACCTCACCGACCGAGTTGGGGAGGTGCCAGCGAGCTTGATGCACGAGGTTGACCGAGG
ACTTCGTCGCGTACTGGACCTTTGA

Antitoxin


Download         Length: 83 a.a.        Molecular weight: 9290.34 Da        Isoelectric Point: 4.3757

>AT61475 WP_003410014.1 NZ_CP014566:c2206322-2206074 [Mycobacterium tuberculosis variant bovis BCG str. Tokyo 172]
MKTAISLPDETFDRVSRRASELGMSRSEFFTKAAQRYLHELDAQLLTGQIDRALESIHGTDEAEALAVANAYRVLETMDD
EW

Download         Length: 249 bp

>AT61475 NZ_CP014566:c2206322-2206074 [Mycobacterium tuberculosis variant bovis BCG str. Tokyo 172]
ATGAAGACAGCTATTTCTCTGCCGGATGAGACGTTCGATCGGGTATCGCGGCGTGCGAGTGAGCTCGGCATGAGTCGGTC
CGAGTTCTTCACGAAGGCTGCGCAGCGCTACCTGCACGAGCTGGACGCCCAATTGCTCACGGGCCAGATCGACAGGGCTC
TAGAGAGCATCCATGGCACCGACGAAGCGGAGGCCCTCGCCGTGGCCAACGCATACCGCGTGCTAGAAACCATGGACGAT
GAGTGGTGA

Similar Proteins

Only experimentally validated proteins are listed.

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Protein
Organism
Identities (%)
Coverage (%)
Ha-value
No matching records found
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Protein
Organism
Identities (%)
Coverage (%)
Ha-value
No matching records found

Structures

Toxin

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Source
ID
Structure
PDB5HK3
PDB5HK0
PDB5HKC

Antitoxin

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Source
ID
Structure
PDB7WJ0
PDB7WNR
AlphaFold DBA0A7U4FAW9

References