Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) parDE/ParE-RHH
Location 2187830..2188374 Replicon chromosome
Accession NZ_CP014566
Organism Mycobacterium tuberculosis variant bovis BCG str. Tokyo 172

Toxin (Protein)


Gene name parE Uniprot ID G0TLU9
Locus tag AZH48_RS10150 Protein ID WP_003409896.1
Coordinates 2187830..2188126 (-) Length 99 a.a.

Antitoxin (Protein)


Gene name parD Uniprot ID P67299
Locus tag AZH48_RS10155 Protein ID WP_003409899.1
Coordinates 2188123..2188374 (-) Length 84 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
AZH48_RS10095 2182863..2183213 - 351 WP_003409871.1 hypothetical protein -
AZH48_RS10100 2183224..2184126 - 903 WP_003409874.1 hypothetical protein -
AZH48_RS10105 2184147..2184338 - 192 WP_003409876.1 hypothetical protein -
AZH48_RS10110 2184339..2184635 - 297 WP_003409877.1 hypothetical protein -
AZH48_RS10115 2184875..2185090 + 216 WP_003409878.1 antitoxin -
AZH48_RS10120 2185087..2185398 + 312 WP_003409881.1 type II toxin-antitoxin system VapC family toxin -
AZH48_RS22255 2185372..2185893 - 522 WP_010950637.1 hypothetical protein -
AZH48_RS10130 2185868..2186245 + 378 WP_010886136.1 type II toxin-antitoxin system toxin HigB -
AZH48_RS10135 2186287..2186736 + 450 WP_003409886.1 type II toxin-antitoxin system antitoxin HigA -
AZH48_RS10140 2186733..2187278 + 546 WP_003409891.1 SecB-like chaperone -
AZH48_RS10145 2187167..2187781 - 615 WP_003901296.1 hypothetical protein -
AZH48_RS10150 2187830..2188126 - 297 WP_003409896.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
AZH48_RS10155 2188123..2188374 - 252 WP_003409899.1 type II toxin-antitoxin system ParD family antitoxin Antitoxin
AZH48_RS10160 2188361..2188855 + 495 WP_003899099.1 hypothetical protein -
AZH48_RS10165 2189015..2189422 - 408 WP_003409913.1 type II toxin-antitoxin system VapC family toxin -
AZH48_RS10170 2189426..2189698 - 273 WP_003899100.1 type II toxin-antitoxin system Phd/YefM family antitoxin -
AZH48_RS10175 2189731..2190951 - 1221 WP_003409919.1 TetR family transcriptional regulator Mce3R -
AZH48_RS10185 2191838..2192254 + 417 WP_162014414.1 hypothetical protein -
AZH48_RS10190 2192339..2193187 + 849 WP_003409942.1 class I SAM-dependent methyltransferase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(5-93)

Antitoxin

Antitoxin ParD

(2-80)


Sequences

Toxin        


Download         Length: 99 a.a.        Molecular weight: 11268.64 Da        Isoelectric Point: 6.8604

>T61472 WP_003409896.1 NZ_CP014566:c2188126-2187830 [Mycobacterium tuberculosis variant bovis BCG str. Tokyo 172]
VSSRYLLSPAAQAHLEEIWDCTYDRWGVDQAEQYLRELQHAIDRAAANPRIGRACDEIRPGYRKLSAGSHTLFYRVTGEG
TIDVVRVLHQRMDVDRNL

Download         Length: 297 bp

>T61472 NZ_CP014566:c2188126-2187830 [Mycobacterium tuberculosis variant bovis BCG str. Tokyo 172]
GTGAGTAGCCGATACCTTCTCTCGCCTGCCGCGCAGGCACATCTGGAAGAGATCTGGGACTGCACCTATGACCGTTGGGG
TGTCGATCAGGCCGAGCAGTACCTGCGCGAACTTCAACACGCTATCGACCGTGCTGCGGCAAACCCGCGGATCGGACGAG
CGTGCGACGAGATTCGCCCCGGCTATCGCAAGCTCTCGGCCGGGTCACACACGTTGTTCTATCGGGTGACTGGCGAAGGC
ACCATCGACGTCGTGCGAGTCCTGCACCAACGGATGGACGTCGACCGGAACCTCTGA

Antitoxin


Download         Length: 84 a.a.        Molecular weight: 9207.17 Da        Isoelectric Point: 7.0150

>AT61472 WP_003409899.1 NZ_CP014566:c2188374-2188123 [Mycobacterium tuberculosis variant bovis BCG str. Tokyo 172]
VGKNTSFVLDEHYSAFIDGEIAAGRYRSASEVIRSALRLLEDRETQLRALREALEAGERSGSSTPFDFDGFLGRKRADAS
RGR

Download         Length: 252 bp

>AT61472 NZ_CP014566:c2188374-2188123 [Mycobacterium tuberculosis variant bovis BCG str. Tokyo 172]
GTGGGTAAGAACACGTCCTTCGTCCTCGACGAGCACTACAGCGCCTTCATCGACGGCGAGATCGCCGCGGGCCGCTACCG
GTCGGCCAGTGAAGTCATCCGCTCCGCGTTGCGACTGCTCGAGGACCGTGAAACCCAGCTGCGCGCGCTTCGTGAGGCTC
TCGAGGCCGGCGAACGCAGCGGCAGCTCGACACCGTTCGACTTCGACGGATTCCTCGGTCGTAAGCGGGCTGACGCCTCG
CGTGGCCGGTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB G0TLU9

Antitoxin

Source ID Structure
AlphaFold DB A0A7U4BUZ2

References