Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) mazEF/MazF(toxin)
Location 1684235..1684851 Replicon chromosome
Accession NZ_CP014566
Organism Mycobacterium tuberculosis variant bovis BCG str. Tokyo 172

Toxin (Protein)


Gene name mazF Uniprot ID G0TJ74
Locus tag AZH48_RS07930 Protein ID WP_003407593.1
Coordinates 1684534..1684851 (+) Length 106 a.a.

Antitoxin (Protein)


Gene name mazE Uniprot ID A0A7U4BU54
Locus tag AZH48_RS07925 Protein ID WP_011799188.1
Coordinates 1684235..1684537 (+) Length 101 a.a.

Genomic Context

AZH48_RS07915AZH48_RS07920AZH48_RS07925AZH48_RS07930AZH48_RS07935AZH48_RS07940AZH48_RS07960AZH48_RS07945AZH48_RS07950AZH48_RS22225
Location: 1680121..1681968 (1848 bp)
Type: Others
Protein ID: WP_003407585.1
Location: 1681969..1684221 (2253 bp)
Type: Others
Protein ID: WP_003407587.1
Location: 1684235..1684537 (303 bp)
Type: Antitoxin
Protein ID: WP_011799188.1
Location: 1684534..1684851 (318 bp)
Type: Toxin
Protein ID: WP_003407593.1
Location: 1684848..1685852 (1005 bp)
Type: Others
Protein ID: WP_003407596.1
Location: 1685905..1687194 (1290 bp)
Type: Others
Protein ID: WP_003407599.1
Location: 1688814..1689842 (1029 bp)
Type: Others
Protein ID: WP_011799189.1
Location: 1687267..1688040 (774 bp)
Type: Others
Protein ID: WP_003912632.1
Location: 1688098..1688289 (192 bp)
Type: Others
Protein ID: WP_003407609.1
Location: 1688320..1688544 (225 bp)
Type: Others
Protein ID: WP_160522526.1
ToxinAntitoxinOther genes
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Locus tag
Coordinates
Strand
Size (bp)
Protein ID
Product
Description
AZH48_RS079151680121..1681968+1848WP_003407585.1methylmalonyl-CoA mutase small subunit-
AZH48_RS079201681969..1684221+2253WP_003407587.1methylmalonyl-CoA mutase-
AZH48_RS079251684235..1684537+303WP_011799188.1type II toxin-antitoxin system antitoxin MazE4Antitoxin
AZH48_RS079301684534..1684851+318WP_003407593.1type II toxin-antitoxin system toxin endoribonuclease MazF4Toxin
AZH48_RS079351684848..1685852+1005WP_003407596.1methylmalonyl Co-A mutase-associated GTPase MeaB-
AZH48_RS079401685905..1687194+1290WP_003407599.1serine hydrolase-
AZH48_RS079451687267..1688040-774WP_003912632.1class I SAM-dependent methyltransferase-
AZH48_RS079501688098..1688289-192WP_003407609.1dodecin family protein-
AZH48_RS222251688320..1688544-225WP_160522526.1NUDIX domain-containing protein-
AZH48_RS079601688814..1689842+1029WP_011799189.1glycosyltransferase family 2 protein-

Associated MGEs

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MGE
detail
Similar
MGEs
Relative
position
MGE Type
Cargo ARG
Virulence gene
Coordinates
Length (bp)
No matching records found


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

mRNA interferase PemK-like

(6-99)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 106 a.a.        Molecular weight: 11377.97 Da        Isoelectric Point: 7.9950

>T61466 WP_003407593.1 NZ_CP014566:1684534-1684851 [Mycobacterium tuberculosis variant bovis BCG str. Tokyo 172]
VNAPLRGQVYRCDLGYGAKPWLIVSNNARNRHTADVVAVRLTTTRRTIPTWVAMGPSDPLTGYVNADNIETLGKDELGDY
LGEVTPATMNKINTALATALGLPWP

Download         Length: 318 bp

>T61466 NZ_CP014566:1684534-1684851 [Mycobacterium tuberculosis variant bovis BCG str. Tokyo 172]
GTGAACGCGCCGTTGCGTGGTCAGGTCTATCGATGCGACCTCGGATACGGGGCCAAACCGTGGCTCATCGTCTCCAACAA
CGCCCGCAACCGTCACACCGCCGACGTGGTGGCTGTGCGCCTGACAACAACGCGGAGAACCATACCGACCTGGGTCGCCA
TGGGCCCCAGCGATCCATTGACCGGATACGTCAACGCGGACAACATCGAGACCCTCGGCAAAGACGAGCTCGGTGACTAC
CTCGGTGAGGTCACGCCGGCGACGATGAACAAAATCAACACGGCGCTCGCGACCGCGCTGGGGCTACCGTGGCCATGA

Antitoxin


Download         Length: 101 a.a.        Molecular weight: 11199.50 Da        Isoelectric Point: 9.5564

>AT61466 WP_011799188.1 NZ_CP014566:1684235-1684537 [Mycobacterium tuberculosis variant bovis BCG str. Tokyo 172]
VPFLVALSGIILGVRDHSMTVRLDQQTRQRLQDIVKGGYRSANAAIVDAINKRWEALHDEQLDAAYAAAIHDNPAYPYES
EAERSAARARRNARQQRSAQ

Download         Length: 303 bp

>AT61466 NZ_CP014566:1684235-1684537 [Mycobacterium tuberculosis variant bovis BCG str. Tokyo 172]
GTGCCGTTTCTGGTTGCATTATCCGGTATCATCTTGGGCGTGCGTGATCATTCGATGACCGTGCGGCTCGACCAGCAAAC
TCGCCAGCGCCTGCAAGACATTGTGAAAGGCGGATACCGGAGCGCTAATGCGGCGATCGTCGACGCCATCAACAAGCGCT
GGGAGGCGCTACACGATGAGCAACTCGACGCCGCCTACGCGGCCGCGATCCATGACAATCCGGCGTACCCGTACGAGTCT
GAGGCCGAACGGAGCGCCGCGCGGGCCCGGCGCAACGCCAGGCAGCAGCGCTCGGCACAGTGA

Similar Proteins

Only experimentally validated proteins are listed.

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Protein
Organism
Identities (%)
Coverage (%)
Ha-value
No matching records found
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Protein
Organism
Identities (%)
Coverage (%)
Ha-value
No matching records found

Structures

Toxin

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Source
ID
Structure
PDB5XE3
PDB5XE2

Antitoxin

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Source
ID
Structure
AlphaFold DBA0A7U4BU54

References