Detailed information of TA system
Overview
TA module
| Type | II | Classification (family/domain) | relBE/RelE-Phd |
| Location | 1391291..1391850 | Replicon | chromosome |
| Accession | NZ_CP014566 | ||
| Organism | Mycobacterium tuberculosis variant bovis BCG str. Tokyo 172 | ||
Toxin (Protein)
| Gene name | relE | Uniprot ID | G0THS1 |
| Locus tag | AZH48_RS06615 | Protein ID | WP_003898789.1 |
| Coordinates | 1391291..1391584 (-) | Length | 98 a.a. |
Antitoxin (Protein)
| Gene name | relB | Uniprot ID | G0THS2 |
| Locus tag | AZH48_RS06620 | Protein ID | WP_003406322.1 |
| Coordinates | 1391581..1391850 (-) | Length | 90 a.a. |
Genomic Context
Location: 1386884..1387144 (261 bp)
Type: Others
Protein ID: WP_003406302.1
Type: Others
Protein ID: WP_003406302.1
Location: 1387141..1387572 (432 bp)
Type: Others
Protein ID: WP_003406304.1
Type: Others
Protein ID: WP_003406304.1
Location: 1389463..1390323 (861 bp)
Type: Others
Protein ID: WP_003406306.1
Type: Others
Protein ID: WP_003406306.1
Location: 1387595..1389283 (1689 bp)
Type: Others
Protein ID: WP_003910308.1
Type: Others
Protein ID: WP_003910308.1
Location: 1390404..1391234 (831 bp)
Type: Others
Protein ID: WP_003898788.1
Type: Others
Protein ID: WP_003898788.1
Location: 1391291..1391584 (294 bp)
Type: Toxin
Protein ID: WP_003898789.1
Type: Toxin
Protein ID: WP_003898789.1
Location: 1391581..1391850 (270 bp)
Type: Antitoxin
Protein ID: WP_003406322.1
Type: Antitoxin
Protein ID: WP_003406322.1
Location: 1391963..1395658 (3696 bp)
Type: Others
Protein ID: WP_010950509.1
Type: Others
Protein ID: WP_010950509.1
Location: 1395800..1396588 (789 bp)
Type: Others
Protein ID: WP_010950510.1
Type: Others
Protein ID: WP_010950510.1
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Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
|---|---|---|---|---|---|---|
| AZH48_RS06590 | 1386884..1387144 | + | 261 | WP_003406302.1 | type II toxin-antitoxin system antitoxin VapB33 | - |
| AZH48_RS06595 | 1387141..1387572 | + | 432 | WP_003406304.1 | type II toxin-antitoxin system VapC family toxin | - |
| AZH48_RS06600 | 1387595..1389283 | - | 1689 | WP_003910308.1 | PE family protein | - |
| AZH48_RS06605 | 1389463..1390323 | + | 861 | WP_003406306.1 | hypothetical protein | - |
| AZH48_RS06610 | 1390404..1391234 | - | 831 | WP_003898788.1 | SDR family NAD(P)-dependent oxidoreductase | - |
| AZH48_RS06615 | 1391291..1391584 | - | 294 | WP_003898789.1 | type II toxin-antitoxin system mRNA interferase RelE | Toxin |
| AZH48_RS06620 | 1391581..1391850 | - | 270 | WP_003406322.1 | type II toxin-antitoxin system Phd/YefM family antitoxin | Antitoxin |
| AZH48_RS06625 | 1391963..1395658 | - | 3696 | WP_010950509.1 | multifunctional oxoglutarate decarboxylase/oxoglutarate dehydrogenase thiamine pyrophosphate-binding subunit/dihydrolipoyllysine-residue succinyltransferase subunit | - |
| AZH48_RS06630 | 1395800..1396588 | - | 789 | WP_010950510.1 | hypothetical protein | - |
Associated MGEs
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MGE detail | Similar MGEs | Relative position | MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
|---|---|---|---|---|---|---|---|
| No matching records found | |||||||
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 98 a.a. Molecular weight: 11031.57 Da Isoelectric Point: 9.6275
>T61464 WP_003898789.1 NZ_CP014566:c1391584-1391291 [Mycobacterium tuberculosis variant bovis BCG str. Tokyo 172]
VSDDHPYHVAITATAARDLQRLPEKIAAACVEFVFGPLLNNPHRLGKPLRNDLEGLHSARRGDYRVVYAIDDGHHRVEII
HIARRSASYRMNPCRPR
VSDDHPYHVAITATAARDLQRLPEKIAAACVEFVFGPLLNNPHRLGKPLRNDLEGLHSARRGDYRVVYAIDDGHHRVEII
HIARRSASYRMNPCRPR
Download Length: 294 bp
>T61464 NZ_CP014566:c1391584-1391291 [Mycobacterium tuberculosis variant bovis BCG str. Tokyo 172]
GTGAGCGACGACCATCCCTACCACGTGGCGATCACCGCGACAGCGGCACGCGACCTGCAACGCTTACCCGAAAAGATCGC
CGCCGCATGTGTCGAGTTTGTTTTCGGACCGCTGCTTAACAACCCGCATAGGTTGGGCAAGCCGCTGCGCAATGACCTTG
AAGGCCTCCACTCAGCCCGCCGCGGTGATTACCGCGTCGTCTACGCCATCGACGACGGCCACCACCGAGTCGAGATCATC
CACATCGCTCGTCGCAGTGCCAGCTACCGAATGAACCCGTGCCGGCCACGTTAA
GTGAGCGACGACCATCCCTACCACGTGGCGATCACCGCGACAGCGGCACGCGACCTGCAACGCTTACCCGAAAAGATCGC
CGCCGCATGTGTCGAGTTTGTTTTCGGACCGCTGCTTAACAACCCGCATAGGTTGGGCAAGCCGCTGCGCAATGACCTTG
AAGGCCTCCACTCAGCCCGCCGCGGTGATTACCGCGTCGTCTACGCCATCGACGACGGCCACCACCGAGTCGAGATCATC
CACATCGCTCGTCGCAGTGCCAGCTACCGAATGAACCCGTGCCGGCCACGTTAA
Antitoxin
Download Length: 90 a.a. Molecular weight: 9766.97 Da Isoelectric Point: 4.8615
>AT61464 WP_003406322.1 NZ_CP014566:c1391850-1391581 [Mycobacterium tuberculosis variant bovis BCG str. Tokyo 172]
MAVVPLGEVRNRLSEYVAEVELTHERITITRHGHPAAVLISADDLASIEETLEVLRTPGASEAIREGLADVAAGRFVSND
EIRNRYTAR
MAVVPLGEVRNRLSEYVAEVELTHERITITRHGHPAAVLISADDLASIEETLEVLRTPGASEAIREGLADVAAGRFVSND
EIRNRYTAR
Download Length: 270 bp
>AT61464 NZ_CP014566:c1391850-1391581 [Mycobacterium tuberculosis variant bovis BCG str. Tokyo 172]
ATGGCTGTTGTCCCACTGGGCGAAGTCCGCAATCGCCTCTCTGAGTACGTCGCCGAAGTTGAGCTGACACACGAGCGCAT
CACGATAACCCGGCACGGTCATCCGGCGGCGGTATTGATCTCGGCCGATGACCTGGCGTCCATCGAGGAAACGCTGGAGG
TGCTACGCACCCCTGGCGCCAGCGAGGCCATTCGTGAAGGCCTCGCCGATGTTGCCGCAGGGCGCTTCGTGAGCAACGAC
GAGATCCGCAACCGTTACACCGCGCGGTGA
ATGGCTGTTGTCCCACTGGGCGAAGTCCGCAATCGCCTCTCTGAGTACGTCGCCGAAGTTGAGCTGACACACGAGCGCAT
CACGATAACCCGGCACGGTCATCCGGCGGCGGTATTGATCTCGGCCGATGACCTGGCGTCCATCGAGGAAACGCTGGAGG
TGCTACGCACCCCTGGCGCCAGCGAGGCCATTCGTGAAGGCCTCGCCGATGTTGCCGCAGGGCGCTTCGTGAGCAACGAC
GAGATCCGCAACCGTTACACCGCGCGGTGA