Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/PIN(toxin)
Location 712028..712653 Replicon chromosome
Accession NZ_CP014566
Organism Mycobacterium tuberculosis variant bovis BCG str. Tokyo 172

Toxin (Protein)


Gene name vapC Uniprot ID G0TQA0
Locus tag AZH48_RS03235 Protein ID WP_003403218.1
Coordinates 712252..712653 (+) Length 134 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID P9WJ36
Locus tag AZH48_RS03230 Protein ID WP_003403213.1
Coordinates 712028..712255 (+) Length 76 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
AZH48_RS03200 707207..707428 - 222 WP_003898525.1 DUF4926 domain-containing protein -
AZH48_RS03205 707570..708175 + 606 WP_038338260.1 hypothetical protein -
AZH48_RS03210 708194..710761 - 2568 WP_003900188.1 SEC-C domain-containing protein -
AZH48_RS03215 710845..711594 + 750 WP_003898528.1 hypothetical protein -
AZH48_RS03220 711591..711833 + 243 WP_003403210.1 hypothetical protein -
AZH48_RS03230 712028..712255 + 228 WP_003403213.1 antitoxin VapB29 Antitoxin
AZH48_RS03235 712252..712653 + 402 WP_003403218.1 type II toxin-antitoxin system ribonuclease VapC29 Toxin
AZH48_RS22165 712782..712865 + 84 Protein_642 galactose-1-phosphate uridylyltransferase -
AZH48_RS03240 712884..713966 + 1083 WP_031652152.1 galactose-1-phosphate uridylyltransferase -
AZH48_RS03245 713963..715054 + 1092 WP_003403225.1 galactokinase -
AZH48_RS03255 715449..716606 + 1158 WP_003903091.1 hypothetical protein -
AZH48_RS03260 716617..717564 + 948 WP_003403232.1 DUF732 domain-containing protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(3-120)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 134 a.a.        Molecular weight: 13937.76 Da        Isoelectric Point: 5.7441

>T61450 WP_003403218.1 NZ_CP014566:712252-712653 [Mycobacterium tuberculosis variant bovis BCG str. Tokyo 172]
VTVLLDANVLIALVVAEHVHHDAAADWLMASDTGFATCPMTQGSLVRFLVRSGQSAAAARDVVSAVQCTSRHEFWPDALS
FAGVEVAGVVGHRQVTDAYLAQLARSHDGQLATLDSGLAHLHGDVAVLIPTTT

Download         Length: 402 bp

>T61450 NZ_CP014566:712252-712653 [Mycobacterium tuberculosis variant bovis BCG str. Tokyo 172]
GTGACGGTGCTGCTCGACGCCAACGTGCTGATCGCATTGGTGGTCGCCGAGCATGTGCATCATGATGCCGCAGCGGACTG
GCTCATGGCGTCCGACACCGGATTTGCGACCTGCCCGATGACACAAGGAAGCCTGGTTCGATTCCTGGTGCGCTCGGGAC
AGTCCGCGGCGGCGGCTCGGGATGTCGTCAGTGCGGTCCAGTGCACGAGCCGCCACGAATTCTGGCCCGATGCACTCTCT
TTCGCCGGTGTCGAGGTCGCTGGTGTGGTTGGGCACCGGCAGGTGACCGATGCCTACCTTGCCCAGCTCGCGCGAAGCCA
CGACGGGCAGTTGGCGACGCTCGACAGCGGCTTAGCACACCTGCACGGCGACGTCGCGGTACTCATTCCAACGACCACCT
GA

Antitoxin


Download         Length: 76 a.a.        Molecular weight: 8163.17 Da        Isoelectric Point: 5.6307

>AT61450 WP_003403213.1 NZ_CP014566:712028-712255 [Mycobacterium tuberculosis variant bovis BCG str. Tokyo 172]
VRTTIDLPQDLHKQALAIARDTHRTLSETVADLMRRGLAANRPTALSSDPRTGLPLVSVGTVVTSEDVRSLEDEQ

Download         Length: 228 bp

>AT61450 NZ_CP014566:712028-712255 [Mycobacterium tuberculosis variant bovis BCG str. Tokyo 172]
GTGCGCACTACCATCGACCTGCCGCAAGACCTGCACAAGCAGGCACTGGCGATTGCCCGGGATACGCACCGCACGTTGAG
TGAAACGGTCGCCGACCTCATGCGACGAGGCCTGGCCGCCAACCGCCCTACCGCGTTGTCCTCAGACCCCAGAACGGGAT
TGCCTTTGGTGAGCGTCGGGACCGTCGTGACCTCCGAGGACGTGCGTTCATTAGAGGACGAGCAGTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB G0TQA0

Antitoxin

Source ID Structure
AlphaFold DB A0A7U4BSC9

References