Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/LOTUS_5_Limkain_b1-PHD
Location 696085..696731 Replicon chromosome
Accession NZ_CP014566
Organism Mycobacterium tuberculosis variant bovis BCG str. Tokyo 172

Toxin (Protein)


Gene name vapC Uniprot ID O07783
Locus tag AZH48_RS03110 Protein ID WP_003403122.1
Coordinates 696085..696477 (-) Length 131 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID G0TQ86
Locus tag AZH48_RS03115 Protein ID WP_003403125.1
Coordinates 696474..696731 (-) Length 86 a.a.

Genomic Context

AZH48_RS03095AZH48_RS03100AZH48_RS03105AZH48_RS03150AZH48_RS03110AZH48_RS03115AZH48_RS03120AZH48_RS03125AZH48_RS03130AZH48_RS03135AZH48_RS03140AZH48_RS03145
Location: 691745..693273 (1529 bp)
Type: Others
Protein ID: Protein_613
Location: 693270..694478 (1209 bp)
Type: Others
Protein ID: WP_003403114.1
Location: 694483..696033 (1551 bp)
Type: Others
Protein ID: WP_003403119.1
Location: 701102..701413 (312 bp)
Type: Others
Protein ID: WP_003403164.1
Location: 696085..696477 (393 bp)
Type: Toxin
Protein ID: WP_003403122.1
Location: 696474..696731 (258 bp)
Type: Antitoxin
Protein ID: WP_003403125.1
Location: 696914..698149 (1236 bp)
Type: Others
Protein ID: WP_003403128.1
Location: 698400..698813 (414 bp)
Type: Others
Protein ID: WP_003403137.1
Location: 698810..699046 (237 bp)
Type: Others
Protein ID: WP_003403139.1
Location: 699150..699656 (507 bp)
Type: Others
Protein ID: WP_003900973.1
Location: 699770..700240 (471 bp)
Type: Others
Protein ID: WP_003403144.1
Location: 700284..701045 (762 bp)
Type: Others
Protein ID: WP_010950420.1
ToxinAntitoxinOther genes
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Locus tag
Coordinates
Strand
Size (bp)
Protein ID
Product
Description
AZH48_RS03095691745..693273+1529Protein_613virulence factor Mce family protein-
AZH48_RS03100693270..694478+1209WP_003403114.1virulence factor Mce family protein-
AZH48_RS03105694483..696033+1551WP_003403119.1MCE family protein-
AZH48_RS03110696085..696477-393WP_003403122.1type II toxin-antitoxin system toxin ribonuclease C4Toxin
AZH48_RS03115696474..696731-258WP_003403125.1type II toxin-antitoxin system antitoxin VapB4Antitoxin
AZH48_RS03120696914..698149-1236WP_003403128.1ATP-binding protein-
AZH48_RS03125698400..698813-414WP_003403137.1type II toxin-antitoxin system VapC family toxin-
AZH48_RS03130698810..699046-237WP_003403139.1AbrB/MazE/SpoVT family DNA-binding domain-containing protein-
AZH48_RS03135699150..699656-507WP_003900973.1two component system sensor kinase HK1-
AZH48_RS03140699770..700240-471WP_003403144.1HAMP domain-containing protein-
AZH48_RS03145700284..701045-762WP_010950420.1two-component system response regulator TcrA-
AZH48_RS03150701102..701413+312WP_003403164.1hypothetical protein-

Associated MGEs

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MGE
detail
Similar
MGEs
Relative
position
MGE Type
Cargo ARG
Virulence gene
Coordinates
Length (bp)
No matching records found


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(8-122)

Antitoxin

Type II toxin-antitoxin system, antitoxin Phd/YefM

(3-53)


Sequences

Toxin        


Download         Length: 131 a.a.        Molecular weight: 14080.08 Da        Isoelectric Point: 4.6558

>T61447 WP_003403122.1 NZ_CP014566:c696477-696085 [Mycobacterium tuberculosis variant bovis BCG str. Tokyo 172]
VNVRRALADTSVFIGIEATRFDPDRFAGYEWGVSVVTLGELRLGVLQASGPEAAARRLSTYQLAQRFEPLGIDEAVSEAW
ALLVSKLRAAKLRVPINDSWIAATAVAHGIAILTQDNDYAAMPDVEVITI

Download         Length: 393 bp

>T61447 NZ_CP014566:c696477-696085 [Mycobacterium tuberculosis variant bovis BCG str. Tokyo 172]
GTGAACGTACGGCGCGCCCTCGCCGACACATCCGTTTTCATTGGCATCGAGGCGACACGATTCGACCCGGACCGGTTTGC
GGGATACGAATGGGGCGTCTCGGTAGTCACACTCGGCGAGCTGCGGCTCGGGGTGTTGCAAGCCTCCGGCCCCGAGGCCG
CCGCACGTCGGCTCTCCACCTACCAGCTTGCGCAACGGTTCGAACCACTAGGCATCGACGAGGCGGTCTCCGAAGCATGG
GCATTACTGGTGTCCAAGCTGCGCGCCGCCAAACTGCGCGTGCCGATCAACGACAGCTGGATTGCGGCCACAGCCGTGGC
GCACGGCATTGCGATCCTGACCCAAGACAACGACTACGCCGCCATGCCCGACGTCGAGGTCATAACGATCTGA

Antitoxin


Download         Length: 86 a.a.        Molecular weight: 9681.06 Da        Isoelectric Point: 7.0175

>AT61447 WP_003403125.1 NZ_CP014566:c696731-696474 [Mycobacterium tuberculosis variant bovis BCG str. Tokyo 172]
MSATIPARDLRNHTAEVLRRVAAGEEIEVLKDNRPVARIVPLKRRRQWLPAAEVIGELVRLGPDTTNLGEELRETLTQTT
DDVRW

Download         Length: 258 bp

>AT61447 NZ_CP014566:c696731-696474 [Mycobacterium tuberculosis variant bovis BCG str. Tokyo 172]
ATGTCTGCTACGATACCCGCTCGCGATCTTCGCAACCACACCGCCGAGGTACTGCGGCGAGTTGCCGCCGGCGAGGAAAT
CGAGGTGCTCAAGGACAATCGCCCCGTAGCGCGCATCGTTCCGCTCAAGCGGCGCCGCCAATGGTTGCCAGCTGCCGAGG
TGATCGGCGAACTGGTGCGCTTGGGCCCCGATACCACCAATCTGGGCGAGGAGCTGCGAGAGACGCTGACGCAAACCACG
GACGATGTGCGGTGGTGA

Similar Proteins

Only experimentally validated proteins are listed.

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Protein
Organism
Identities (%)
Coverage (%)
Ha-value
No matching records found
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Protein
Organism
Identities (%)
Coverage (%)
Ha-value
No matching records found

Structures

Toxin

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Source
ID
Structure
AlphaFold DBA0A7U4F8V4

Antitoxin

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Source
ID
Structure
AlphaFold DBG0TQ86

References