Detailed information of TA system
Overview
TA module
| Type | II | Classification (family/domain) | hicAB/HicA-HicB |
| Location | 3103334..3103949 | Replicon | chromosome |
| Accession | NZ_CP014546 | ||
| Organism | Pseudomonas azotoformans strain S4 | ||
Toxin (Protein)
| Gene name | hicA | Uniprot ID | W2D6J2 |
| Locus tag | AYR47_RS14385 | Protein ID | WP_012722731.1 |
| Coordinates | 3103767..3103949 (-) | Length | 61 a.a. |
Antitoxin (Protein)
| Gene name | hicB | Uniprot ID | W2D6D2 |
| Locus tag | AYR47_RS14380 | Protein ID | WP_033902677.1 |
| Coordinates | 3103334..3103744 (-) | Length | 137 a.a. |
Genomic Context
| Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
|---|---|---|---|---|---|---|
| AYR47_RS14340 | 3098872..3099789 | + | 918 | WP_061435649.1 | LysR family transcriptional regulator | - |
| AYR47_RS14345 | 3099797..3100081 | - | 285 | WP_033902682.1 | type II toxin-antitoxin system RelE/ParE family toxin | - |
| AYR47_RS14350 | 3100071..3100310 | - | 240 | WP_016975132.1 | ribbon-helix-helix protein, CopG family | - |
| AYR47_RS14355 | 3100415..3100825 | + | 411 | WP_033902681.1 | fosfomycin resistance glutathione transferase | - |
| AYR47_RS14360 | 3100880..3101521 | + | 642 | WP_033902680.1 | LysE family translocator | - |
| AYR47_RS14365 | 3101641..3102168 | + | 528 | WP_016975135.1 | DUF4142 domain-containing protein | - |
| AYR47_RS14370 | 3102223..3102648 | - | 426 | WP_038842343.1 | low affinity iron permease family protein | - |
| AYR47_RS14375 | 3102730..3103230 | - | 501 | WP_033902678.1 | methylated-DNA--[protein]-cysteine S-methyltransferase | - |
| AYR47_RS14380 | 3103334..3103744 | - | 411 | WP_033902677.1 | type II toxin-antitoxin system HicB family antitoxin | Antitoxin |
| AYR47_RS14385 | 3103767..3103949 | - | 183 | WP_012722731.1 | type II toxin-antitoxin system HicA family toxin | Toxin |
| AYR47_RS14390 | 3104119..3105012 | - | 894 | WP_061435651.1 | LysR family transcriptional regulator | - |
| AYR47_RS14395 | 3105108..3106271 | + | 1164 | WP_061435653.1 | MFS transporter | - |
| AYR47_RS14400 | 3106268..3107434 | + | 1167 | WP_061435655.1 | MFS transporter | - |
| AYR47_RS14405 | 3107427..3107735 | - | 309 | WP_033902673.1 | putative addiction module antidote protein | - |
| AYR47_RS14410 | 3107738..3108031 | - | 294 | WP_025999642.1 | type II toxin-antitoxin system RelE/ParE family toxin | - |
| AYR47_RS14420 | 3108498..3108737 | + | 240 | WP_033902672.1 | hypothetical protein | - |
Associated MGEs
| MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
|---|---|---|---|---|---|---|---|
| - | inside | Prophage | - | - | 3096983..3107926 | 10943 |
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 61 a.a. Molecular weight: 6775.96 Da Isoelectric Point: 10.7532
>T61433 WP_012722731.1 NZ_CP014546:c3103949-3103767 [Pseudomonas azotoformans]
VDSRYLIGHIVADGWYLARIRGSHHHFKHPTKPGLVTIPHPKKDLLDKTAKSILKQALLS
VDSRYLIGHIVADGWYLARIRGSHHHFKHPTKPGLVTIPHPKKDLLDKTAKSILKQALLS
Download Length: 183 bp
>T61433 NZ_CP014546:c3103949-3103767 [Pseudomonas azotoformans]
GTGGATAGCCGATATTTGATAGGTCACATCGTTGCGGACGGTTGGTATCTGGCGCGTATCAGAGGGAGTCATCATCACTT
CAAGCACCCGACTAAACCGGGGCTGGTGACGATTCCACATCCAAAGAAGGACCTGTTGGACAAGACCGCCAAGAGCATTT
TGAAACAAGCTCTGTTGAGTTAA
GTGGATAGCCGATATTTGATAGGTCACATCGTTGCGGACGGTTGGTATCTGGCGCGTATCAGAGGGAGTCATCATCACTT
CAAGCACCCGACTAAACCGGGGCTGGTGACGATTCCACATCCAAAGAAGGACCTGTTGGACAAGACCGCCAAGAGCATTT
TGAAACAAGCTCTGTTGAGTTAA
Antitoxin
Download Length: 137 a.a. Molecular weight: 14721.60 Da Isoelectric Point: 4.3123
>AT61433 WP_033902677.1 NZ_CP014546:c3103744-3103334 [Pseudomonas azotoformans]
MLYPIAISTGDEDHAWGVEVPDIPGCYSAGDDLDDAMAMAREAIEGHFEILAEDGAPIPSAQKVTLHAANPQYAGCTWAV
VDIDVTKYLGKAQKLNITLPGYLLNRIDEYVLHHPEEKSRSGFLASAALKVLQQEG
MLYPIAISTGDEDHAWGVEVPDIPGCYSAGDDLDDAMAMAREAIEGHFEILAEDGAPIPSAQKVTLHAANPQYAGCTWAV
VDIDVTKYLGKAQKLNITLPGYLLNRIDEYVLHHPEEKSRSGFLASAALKVLQQEG
Download Length: 411 bp
>AT61433 NZ_CP014546:c3103744-3103334 [Pseudomonas azotoformans]
ATGCTTTACCCGATTGCAATTTCAACCGGTGACGAGGATCACGCCTGGGGCGTGGAAGTGCCGGATATTCCTGGTTGCTA
TTCCGCCGGTGACGACCTGGACGACGCCATGGCCATGGCCCGCGAAGCCATCGAAGGGCACTTCGAGATCCTGGCCGAAG
ACGGTGCGCCGATTCCCAGTGCGCAGAAGGTCACCCTGCATGCCGCCAACCCCCAGTACGCAGGCTGCACCTGGGCCGTG
GTAGACATTGATGTCACCAAGTATCTGGGCAAGGCGCAGAAGCTCAACATCACGTTGCCGGGTTACCTGCTGAACCGCAT
CGATGAATATGTACTGCACCATCCGGAAGAAAAAAGCCGCTCGGGGTTTCTGGCATCGGCGGCGCTTAAAGTGCTGCAAC
AGGAGGGGTAA
ATGCTTTACCCGATTGCAATTTCAACCGGTGACGAGGATCACGCCTGGGGCGTGGAAGTGCCGGATATTCCTGGTTGCTA
TTCCGCCGGTGACGACCTGGACGACGCCATGGCCATGGCCCGCGAAGCCATCGAAGGGCACTTCGAGATCCTGGCCGAAG
ACGGTGCGCCGATTCCCAGTGCGCAGAAGGTCACCCTGCATGCCGCCAACCCCCAGTACGCAGGCTGCACCTGGGCCGTG
GTAGACATTGATGTCACCAAGTATCTGGGCAAGGCGCAGAAGCTCAACATCACGTTGCCGGGTTACCTGCTGAACCGCAT
CGATGAATATGTACTGCACCATCCGGAAGAAAAAAGCCGCTCGGGGTTTCTGGCATCGGCGGCGCTTAAAGTGCTGCAAC
AGGAGGGGTAA
Similar Proteins
Only experimentally validated proteins are listed.
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
Structures
Toxin
| Source | ID | Structure |
|---|---|---|
| AlphaFold DB | W2D6J2 |
Antitoxin
| Source | ID | Structure |
|---|---|---|
| AlphaFold DB | A0A7Y8G830 |